Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 2

Conditions

• Post-Traumatic Headache

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Bupivacaine bilateral greater occipital nerve block — OTHER
  Three subcutaneous injections of 1 mL each will be injected on both sides of the occipital region around the greater occipital nerve.

Study Details

Anesthetic greater occipital nerve (GON) blockade is a simple, inexpensive, and safe procedure that has demonstrable headache pain suppressing effects. In this study, Veterans with post-traumatic headache will be randomized to receive 0.0%, 0.05%, or 0.5% bupivacaine in bilateral GON blocks and the lasting (i.e., transitional) effects on headache frequency measured in a headache diary.

Key Dates

First listed

Aug 31, 2026

Start date

Sep 1, 2026

Status verified

Aug 2026

Primary completion

Sep 30, 2027

Completion

Dec 31, 2027

Study Design

Enrollment

36 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Placebo Comparator: Placebo
  0.0% bupivacaine (normal saline)
• Active Comparator: Low dose bupivacaine
  0.05% bupivacaine
• Experimental: Full dose bupivacaine
  0.5% bupivacaine

Primary Outcome Measure

Change in headache days/week in the first month [ Time Frame: From one month before to one month after injection ]

Central Contacts

• Emmanuelle Schindler, MD, PhD
  203-932-5711
  [email protected]

Locations (1)

Find similar trials in West Haven, CT

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