A Study of RO7890597 in Healthy Adult Volunteers

Part of paid clinical trials in Lenexa, Kansas.

Sponsor
Genentech, Inc.
Study ID
NCT07797478
Phase
PHASE1
Status
Recruiting
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Conditions

  • Healthy Volunteers

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • RO7890597 — DRUG
    Participants will receive RO7890597 as per the schedule described in the protocol.
  • Placebo — DRUG
    Participants will receive matching placebo as per the schedule described in the protocol.
  • Rabeprazole — DRUG
    Participants will receive rabeprazole as per the schedule described in the protocol.
  • Itraconazole — DRUG
    Participants will receive itraconazole as per the schedule described in the protocol.

Study Details

This study will evaluate the safety, pharmacokinetics (PK), and activity of single and multiple doses of RO7890597 compared with placebo in healthy volunteers. The study includes single ascending dose (SAD) stage, multiple ascending dose (MAD) stage, food-effect and proton pump inhibitor (PPI) stages, and a supplemental drug-drug interaction (DDI) stage.

Key Dates

First listed
Sep 1, 2026
Start date
Aug 28, 2026
Status verified
Aug 2026
Primary completion
Jun 8, 2027
Completion
Jun 8, 2027

Study Design

Enrollment
139 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: RO7890597
    Participants will receive a single or multiple doses of RO7890597 alone, or with rabeprazole or itraconazole.
  • Experimental: Placebo
    Participants will receive single or multiple doses of matching placebo.

Primary Outcome Measure

Incidence and Severity of Adverse Events (AEs) [ Time Frame: Up to approximately 12 weeks ]

Central Contacts

  • Reference Study ID Number: GA46708 https://forpatients.roche.com/ No attachments to email below.
    888-662-6728 (U.S. and Canada)
    [email protected]
  • Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Locations (1)

FacilityCityStateZIPSite coordinators
ICON (LPRA) - LenexaLenexaKansas66219-

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