A Study of Stereotactic Radiosurgery (SRS) in People With Brain Cancer Having Tumor Resection Surgery

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07802353
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Brain Metastasases

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Stereotactic Radiosurgery — RADIATION
    Stereotactic Radiosurgery (SRS) to the index lesion will be delivered with standard of care technique at doses of 18Gy or 21Gy, for tumors \>3cm and ≤3cm, respectively, in a single fraction.
  • Surgical Resection — PROCEDURE
    Patients will undergo standard-of-care surgical resection of the index lesion within 10 days of SRS, and no later than 21 days to accommodate operating room availability.

Study Details

The researchers are doing this study to see if treating people's brain tumors with stereotactic radiosurgery (SRS) before tumor resection surgery will prevent cancer cells from spreading to other areas of the brain, including the fluid and lining around the brain, during surgery, and lead to better surgical outcomes and fewer complications after surgery (post-surgery complications). Only one brain tumor (the index tumor) will be treated with the study radiosurgery and then removed by surgery. If there are other brain tumors, they will not be removed by surgery in this study, although they may be treated separately with standard radiation if the doctor decides it is needed.

Key Dates

First listed
Sep 3, 2026
Start date
Aug 28, 2026
Status verified
Aug 2026
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
50 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Stereotactic RadioSurgery
    Patients will be seen by an attending radiation oncologist before receiving SRS. Standard of are history and physical will be obtained. An MRI brain with contrast will be performed within seven days of the CT simulation for SRS planning. Surgical resection of the index lesion is to be performed within 10 days of SRS, and no later than 21 days to accommodate operating room availability.

Primary Outcome Measure

local failure, pachymeningeal disease, classical leptomeningeal disease, symptomatic radiation necrosis, or death from any cause. [ Time Frame: 1 year ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920
Luke Pike, MD
212-639-8157
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)MiddletownNew Jersey07748
Luke Pike, MD
212-639-8157
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645
Luke Pike, MD
212-639-8157
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)CommackNew York11725
Luke Pike, MD
212-639-8157
Memorial Sloan Kettering Westchester (Limited Protocol Activities)East White PlainsNew York10604
Luke Pike, MD
201-775-7604
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New YorkNew York10065
Luke Pike, MD
201-775-7604
Memorial Sloan Kettering Nassau (Limited Protocol Activities)Rockville CentreNew York11553
Luke Pike, MD
212-639-8157

Find similar trials in Basking Ridge, NJ

By research site
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Limited Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (Limited Protocol Activities)· East White Plains, NYMemorial Sloan Kettering Cancer Center (All Protocol Activities)· New York, NY

Related Studies