PENG Block Versus Intrathecal Morphine for Early Postoperative Recovery After Total Hip Arthroplasty

Sponsor
Erzincan Binali Yildirim Universitesi
Study ID
NCT07803133
Status
Not Yet Recruiting

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Conditions

  • Postoperative Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Pericapsular nerve group (PENG) block — PROCEDURE
    Participants will receive an ultrasound-guided pericapsular nerve group (PENG) block after spinal anesthesia. The total injectate volume will be 20 mL, with an intended dose of 100 mg bupivacaine (20 mL of 0.5% bupivacaine). The bupivacaine dose will be reduced when necessary to ensure that the total bupivacaine dose, including the dose administered for spinal anesthesia, does not exceed 2 mg/kg. When dose reduction is required, 0.9% saline will be added to maintain a total injectate volume of 20 mL.
  • Intrathecal Morphine — DRUG
    100 micrograms of preservative-free morphine administered intrathecally during spinal anesthesia

Study Details

The goal of this clinical trial is to compare the PENG block with intrathecal morphine for early postoperative recovery and pain control in adults undergoing elective total hip arthroplasty. The main question it aims to answer is: Is there a difference between PENG block and intrathecal morphine in quality of recovery 24 hours after surgery, as measured by the Quality of Recovery-15 (QoR-15) questionnaire? Researchers will also compare postoperative pain, opioid use, mobilization, motor function, and treatment-related side effects between the two groups. Participants will be randomly assigned to receive either a PENG block or intrathecal morphine in addition to spinal anesthesia and standard multimodal pain treatment. Participants will complete the QoR-15 questionnaire before surgery and 24 hours after surgery. Pain scores, opioid use, mobilization, motor function, and side effects will be assessed during the first 24 hours after surgery.

Key Dates

First listed
Sep 3, 2026
Start date
Sep 1, 2026
Status verified
Aug 2026
Primary completion
Sep 1, 2027
Completion
Sep 1, 2027

Study Design

Enrollment
90 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: PENG Block Group
    Participants assigned to this group will receive an ultrasound-guided PENG block after spinal anesthesia. The PENG block will have a total injectate volume of 20 mL, with an intended dose of 100 mg bupivacaine (20 mL of 0.5% bupivacaine). The bupivacaine dose will be reduced when necessary to ensure that the total bupivacaine dose, including the dose administered for spinal anesthesia, does not exceed 2 mg/kg. When dose reduction is required, 0.9% saline will be added to maintain a total injectate volume of 20 mL. All other perioperative anesthesia and multimodal analgesia will be standardized.
  • Experimental: Intrathecal Morphine Group
    Participants assigned to this group will receive 100 micrograms of preservative-free intrathecal morphine during spinal anesthesia. All other perioperative anesthesia and multimodal analgesia will be standardized.

Primary Outcome Measure

Quality of Recovery-15 (QoR-15) Score at 24 Hours After Surgery [ Time Frame: 24 hours after surgery ]

Central Contacts

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