Endovascular Treatment for Symptomatic Non-acute Carotid Occlusion

Sponsor
Dapeng Mo
Study ID
NCT07803419
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

  • Cognitive Impairment
  • Non-acute Carotid Artery Occlusion

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Guideline-Based Best Medical Treatment — OTHER
    Guideline-based best medical treatment includes antiplatelet therapy and management of vascular risk factors, such as blood pressure, lipid, glucose, and lifestyle management, according to current clinical practice.
  • Endovascular Recanalization With Proximal Balloon Protection — PROCEDURE
    Endovascular recanalization will be performed using neurointerventional techniques. A balloon guide catheter will be positioned proximally to achieve temporary flow arrest or flow control during key lesion-treatment steps, with the aim of reducing distal migration of thrombus or plaque debris.
  • Endovascular Recanalization Without Proximal Protection — PROCEDURE
    Endovascular recanalization will be performed using standard neurointerventional techniques without routine proximal balloon flow arrest or flow control.

Study Details

This study is a multicenter, prospective, randomized, open-label, blinded-endpoint clinical trial designed to evaluate the safety and potential efficacy of endovascular recanalization strategies in patients with symptomatic non-acute carotid artery occlusion and cognitive impairment. Eligible participants will be randomly assigned to best medical treatment alone, endovascular recanalization without proximal protection plus best medical treatment, or endovascular recanalization with proximal balloon protection plus best medical treatment. The study will assess whether endovascular recanalization improves cognitive function and whether proximal protection reduces procedure-related new ischemic lesions on diffusion-weighted magnetic resonance imaging.

Key Dates

First listed
Sep 3, 2026
Start date
Sep 1, 2026
Status verified
Aug 2026
Primary completion
Jun 1, 2028
Completion
Dec 1, 2028

Study Design

Enrollment
180 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Best Medical Treatment
    Participants in this arm will receive guideline-based best medical treatment, including antiplatelet therapy and management of vascular risk factors.
  • Experimental: Endovascular Recanalization With Proximal Balloon Protection Plus Best Medical Treatment
    Participants in this arm will undergo endovascular recanalization with proximal balloon protection in addition to guideline-based best medical treatment. Proximal balloon protection will be used to achieve temporary proximal flow arrest or flow control during key procedural steps.
  • Experimental: Endovascular Recanalization Without Proximal Protection Plus Best Medical Treatment
    Participants in this arm will undergo endovascular recanalization without routine proximal balloon flow control, in addition to guideline-based best medical treatment.

Primary Outcome Measure

Changes of cognitive function (MoCA score) compared with baseline 6 months after randomization [ Time Frame: 6 months after randomization ]

Central Contacts

Related Studies