A Predictive Model for Postoperative Analgesic Requirements After Abdominal Surgery

Sponsor
Chaw Sook Hui
Study ID
NCT07803575
Status
Not Yet Recruiting

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Conditions

  • Opioid Analgesic Requirement
  • Pain Management After Abdominal Surgery
  • Postoperative Analgesia
  • Postoperative Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Intravenous Morphine Patient-Controlled Analgesia — DRUG
    Participants will receive intravenous morphine via patient-controlled analgesia (PCA) as part of standard postoperative analgesic management following elective abdominal surgery. The study does not assign or modify analgesic treatment. Morphine PCA usage, including timing and dose of successful administrations, will be recorded to characterise postoperative analgesic requirements using repeated time-to-event modelling.

Study Details

Postoperative pain remains a common challenge after abdominal surgery despite the use of standard multimodal pain management strategies. Poorly controlled pain can delay recovery, limit early mobilisation, reduce patient comfort, and increase the risk of longer-term pain problems. This study aims to develop a predictive model to better understand and anticipate patients' postoperative pain relief needs after abdominal surgery. The study will observe adults undergoing elective abdominal surgery and collect information on their pain scores, pain medication use, surgical characteristics, and recovery during the first 48 hours after surgery. Participants will receive standard postoperative pain management according to usual clinical practice. The study will analyse patterns of rescue pain medication use, including when and how often additional pain relief is required after surgery. The collected information will be used to develop a model that can predict factors associated with increased pain medication requirements. The goal of this research is to improve understanding of individual differences in postoperative pain and provide a foundation for more personalised pain management strategies in the future. The findings may help healthcare providers identify patients who are more likely to require additional pain relief and support the development of safer and more effective approaches to postoperative pain control.

Key Dates

First listed
Sep 3, 2026
Start date
Jan 31, 2027
Status verified
Sep 2026
Primary completion
Jul 31, 2027
Completion
Jun 30, 2028

Study Design

Enrollment
65 participants (estimated)

Arms

  • Arm: Adult Patients Undergoing Elective Abdominal Surgery
    Adult patients aged 18-75 years undergoing elective open or laparoscopic abdominal surgery under general anaesthesia will be enrolled in this prospective observational cohort. Participants will receive standard postoperative analgesic management according to routine clinical practice. Rescue analgesia will be provided using intravenous morphine via patient-controlled analgesia (PCA), and the timing and dose of successful analgesic administrations will be recorded during the first 48 hours after surgery. Patient demographics, surgical characteristics, pain scores, and analgesic administration data will be collected to develop a predictive model of postoperative analgesic requirements.

Primary Outcome Measure

Rescue Analgesic Administration Events During the First 48 Hours After Abdominal Surgery [ Time Frame: Up to 48 hours after completion of surgery ]

Central Contacts

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