A Clinical Investigation of a Topical Moisturizer on Skin Barrier Function in Adults With Sensitive Skin

Conditions

• Sensitive Skin

Eligibility Criteria

Sex

ALL

Age

18 Years - 55 Years

Healthy Volunteers

Not accepted

Interventions

• White petrolatum — OTHER
  Dose per Application: 6 full pumps per application to the assigned forearm.
• Investigational moisturizer — OTHER
  Dose per Application: 6 full pumps per application to the assigned forearm.

Study Details

The purpose of this research study is to evaluate whether a marketed moisturizing cream can improve skin barrier function (how well the outer layer of the skin keeps moisture in and protects the skin), skin hydration, skin sensitivity, inflammatory biomarkers (proteins in the skin that can provide information about inflammation), and the skin microbiome (the microorganisms that naturally live on the skin) in adults with sensitive skin, when compared with a commonly used moisturizing ointment (White Petrolatum) a widely used occlusive ointment (an ointment that forms a protective layer over the skin to help reduce moisture loss).

Key Dates

First listed

Sep 10, 2026

Start date

Sep 14, 2026

Status verified

Sep 2026

Primary completion

Dec 16, 2026

Completion

Jan 12, 2027

Study Design

Enrollment

24 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Placebo Comparator: Occlusive comparator control
  White Petrolatum, USP
• Experimental: Investigational moisturizer
  Marketed Moisturizer

Primary Outcome Measure

Transepidermal Water Loss (TEWL) [ Time Frame: Baseline and Day 28 ]

Central Contacts

• Dashi, PhD
  +1 (646) 663-5260
  [email protected]

Locations (1)

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