Targeted Ablation to Isolate Scar Channels Causing Ventricular Tachycardia

Part of paid clinical trials in Valhalla, New York.

Sponsor
New York Medical College
Study ID
NCT07814079
Status
Recruiting
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Conditions

  • Ischemic Cardiomyopathy
  • Nonischemic Cardiomyopathy
  • Ventricular Tachycardia (VT)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Selective Substrate Isolation — PROCEDURE
    Ablation will be guided by mapping the substrate "from the inside out" by identifying conducting channels as they might be activated during VT. Extensive pace mapping will be performed within scar areas identified during sinus rhythm mapping. The course of these channels will be identified and ablated across the distal portion, just proximal to the exit based on shortest stimulus-to-QRS interval obtained.

Study Details

The goal of this study is to map conducting channels within scar that cause ventricular tachycardia (VT) in patients with scar in their hearts in order to block these channels from causing VT with targeted radiofrequency ablation (cautery). Participants undergoing VT ablation mapping of these channels by pacing many sites within the scar area and determining where these channels exit the scar into normal tissue. These exits will be ablated. Immediate success and success at 1 year will be evaluated.

Key Dates

First listed
Sep 10, 2026
Start date
Mar 27, 2025
Status verified
Aug 2026
Primary completion
Dec 9, 2027
Completion
Dec 9, 2028

Study Design

Enrollment
30 participants (estimated)

Primary Outcome Measure

Number of participants achieving substrate Isolation with ablation of exit sites [ Time Frame: Perioperative/Periprocedural: This will be measured at the end of the study ablation procedure only. ]

Locations (1)

FacilityCityStateZIPSite coordinators
Westchester Medical CenterValhallaNew York10595
Jason T Jacobson, MD
[email protected]
9144935314
Sei Iwai, MD
[email protected]
9149096900
Jason Jacobson, MD (PRINCIPAL_INVESTIGATOR)
Sei Iwai, MD (SUB_INVESTIGATOR)
Daniel Frenkel, MD (SUB_INVESTIGATOR)

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By research site
Westchester Medical Center· Valhalla, NY

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