Hyperpolarized Xenon MRI in Adults With Pulmonary Hypertension in Interstitial Lung Disease and Systemic Sclerosis

Sponsor
Bastiaan Driehuys
Study ID
NCT07821398
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Hyperpolarized 129 Xenon Gas — DRUG
    Hyperpolarized xenon gas is inhaled during MRI to evaluate lung ventilation and gas exchange.

Study Details

This study aims to evaluate a noninvasive magnetic resonance imaging technique using hyperpolarized xenon gas to measure lung function in adults with interstitial lung disease, pulmonary hypertension, and systemic sclerosis. Researchers will assess whether MRI measurements correlate with clinical measures of lung and vascular function.

Key Dates

First listed
Sep 15, 2026
Start date
Nov 1, 2026
Status verified
Sep 2026
Primary completion
Apr 20, 2030
Completion
Apr 20, 2030

Study Design

Enrollment
51 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Hyperpolarized Xenon MRI
    Participants undergo hyperpolarized Xenon MRI imaging and clinical assessments.

Primary Outcome Measure

Diagnostic Accuracy for Detection of Pulmonary Hypertension (sensitivity) [ Time Frame: Single study visit, Day 1 ]

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