Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT07823101
Status
Recruiting
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Conditions

  • ALS (Amyotrophic Lateral Sclerosis)
  • IBM
  • Inclusion Body Myositis
  • Myopathy
  • Myositis
  • PLS

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

This study will evaluate whether neuromuscular ultrasound and MRI can be used as imaging markers of bulbar involvement and swallowing dysfunction in individuals with inclusion body myositis (IBM). Researchers will compare imaging and clinical findings in participants with IBM with those in participants with other myopathies, ALS, PLS, and healthy volunteers. The study is a one-time visit. Study procedures may include neurological assessments, swallowing questionnaires, tongue strength testing, neuromuscular ultrasound, and MRI. The goal is to identify more sensitive and objective ways to assess bulbar dysfunction biomarkers.

Key Dates

First listed
Sep 16, 2026
Start date
Oct 31, 2026
Status verified
Sep 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
30 participants (estimated)

Arms

  • Arm: Inclusion Body Myositis
    Participants with diagnosis of IBM
  • Arm: Inflammatory or Genetic Myopathies
    other types of myopathy that is not IBM
  • Arm: Motor neuron disease(ALS/PLS)
    Participants must have spastic dysarthria
  • Arm: Healthy controls

Primary Outcome Measure

Bulbar Muscle Thickness Assessed by Neuromuscular Ultrasound [ Time Frame: Day 1 (one-time study visit) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The Johns Hopkins HospitalBaltimoreMaryland21287
Abdullah AlQahtani, MD MPH
[email protected]
443-819-9480

Find similar trials in Baltimore, MD

By research site
The Johns Hopkins Hospital· Baltimore, MD

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