A Study of the Jovi Patch, Powered by Signal Relief, for the Improvement of General Menstrual Discomfort

Conditions

• General Menstrual Discomfort

Eligibility Criteria

Sex

FEMALE

Age

18 Years - 50 Years

Healthy Volunteers

Not accepted

Interventions

• Jovi Patch — DEVICE
  Non-invasive, drug-free flexible wellness patch containing conductive particle arrays
• Sham Patch — DEVICE
  Matching inactive (sham) patch that is identical in appearance to the active Jovi Patch but does not contain the conductive particle arrays

Study Details

This pilot study is testing whether a thin, flexible, drug-free patch called the Jovi Patch (powered by Signal Relief) can help reduce general menstrual discomfort (pain and related symptoms during periods). The patch contains no medication, wires, or batteries. It uses special micro-metal particles that are thought to interact with the body's natural electrical signals related to pain. Researchers will compare an active version of the patch to a look-alike sham (inactive) patch. About 50 pre-menopausal women ages 18-50 who have menstrual discomfort (pain score greater than 4 on a 0-10 scale) will be randomly assigned to one of two groups: Active patch group (larger group) Sham patch group Participants will wear their assigned patch during six menstrual cycles (starting the day before their period begins and continuing through the week of flow). After three cycles, women in the sham group will switch to the active patch for the remaining three cycles so researchers can also look at the effects of switching. The main question is whether more women using the active patch achieve at least a 30% reduction in their pain scores compared with those using the sham patch. The study will also track changes in how much menstrual symptoms interfere with daily life, use of pain medications, and any side effects (such as skin irritation). Participation lasts through six menstrual cycles. The overall study is expected to take up to 12 months.

Key Dates

First listed

Sep 17, 2026

Start date

May 8, 2026

Status verified

Sep 2026

Primary completion

Jun 30, 2027

Completion

Jul 31, 2027

Study Design

Enrollment

50 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

SUPPORTIVE_CARE

Arms

• Active Comparator: Active Jovi Patch
  Participants receive the active Jovi Patch (powered by Signal Relief), a non-invasive, drug-free flexible wellness patch containing conductive particle arrays. The patch is worn during six consecutive menstrual cycles (or three cycles if crossing over from sham).
• Sham Comparator: Sham Patch
  Participants receive a matching inactive (sham) patch that is identical in appearance to the active Jovi Patch but does not contain the conductive particle arrays. After three cycles, these participants cross over to the active Jovi Patch for the remaining three cycles.

Primary Outcome Measure

Proportion of Participants Achieving at Least 30% Change in NPRS Score [ Time Frame: Baseline to end of treatment (after 6 menstrual cycles) ]

Central Contacts

• Ashley Trymbiski
  4452008090
  [email protected]

Locations (1)

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