A Study of Vepugratinib (LY3866288) in Adults With Non-Muscle Invasive Bladder Cancer and Upper Tract Urothelial Cancer

Part of paid clinical trials in Myrtle Beach, South Carolina.

Sponsor
Eli Lilly and Company
Study ID
NCT07827612
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

  • Receptor, Fibroblast Growth Factor, Type 3
  • Urinary Bladder Neoplasms
  • Urologic Neoplasms

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Vepugratinib — DRUG
    Administered orally

Study Details

The main purpose of this study is to see how well vepugratinib works in adults with low grade, intermediate risk, non-muscle invasive bladder cancer (LG IR NMIBC) or low-grade upper tract urothelial carcinoma (LG UTUC). Safety tests will also be conducted. For each participant, the study will last up to 5 years.

Key Dates

First listed
Sep 18, 2026
Start date
Dec 31, 2026
Status verified
Aug 2026
Primary completion
Jul 31, 2028
Completion
Mar 31, 2031

Study Design

Enrollment
161 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Cohort A: Vepugratinib
    Vepugratinib will be administered orally to participants with low-grade intermediate-risk non-muscle invasive bladder cancer (LG IR NMIBC)
  • Experimental: Cohort B: Vepugratinib
    Vepugratinib will be administered orally to participants with low-grade upper tract urothelial carcinoma (LG UTUC)

Primary Outcome Measure

Number of Participants with LG IR NMIBC with Complete Response [ Time Frame: Baseline, 2 Years ]

Central Contacts

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
    1-317-615-4559
    [email protected]
  • Physicians interested in becoming principal investigators please contact
    [email protected]

Locations (1)

FacilityCityStateZIPSite coordinators
Carolina Urologic Research Center, LLCMyrtle BeachSouth Carolina29572-

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Carolina Urologic Research Center, LLC· Myrtle Beach, SC

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