Can SAP P11-4 Affect The Appearance of Interproximal Cavities on an X-ray in a Military Population

Conditions

• Incipient Interproximal Caries

Eligibility Criteria

Sex

ALL

Age

18 Years - 74 Years

Healthy Volunteers

Not accepted

Interventions

• 0.05% Sodium Fluoride with Self-Assembling Peptides — DRUG
  Single topical application of Curodont Repair Fluoride Plus (containing 0.05% sodium fluoride and self-assembling P11-4 peptide technology) directly to identified non-cavitated interproximal early carious lesions (radiographic stages E1, E2, or D1) at baseline per manufacturer instructions. Participants receive standardized oral hygiene instruction (OHI) reinforcing brushing and flossing technique and frequency at baseline and at all recall appointments. Follow-up standardized bitewing radiographs are obtained at 1 week, 1 month, and 3 months with no real-time filters or enhancements to evaluate lesion density changes via pixel region-of-interest (ROI) analysis.

Study Details

The primary objective of the protocol is to learn about how SAP P 11-4 (produced commercially as Curodont products) can be used in a military population to treat incipient dental caries, or developing cavities that are still structurally intact and not too deep and increase awareness of the improvement and availability of minimally invasive treatment options for cavities in a military population.

Key Dates

First listed

Sep 21, 2026

Start date

Sep 30, 2026

Status verified

Aug 2026

Primary completion

Feb 28, 2027

Completion

Aug 31, 2027

Study Design

Enrollment

30 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Arms

• Experimental: Curodont Repair Fluoride Plus Treatment Group
  Participants with non-cavitated interproximal carious lesions (E1, E2, or D1) receive a single topical application of Curodont Repair Fluoride Plus at baseline following standardized bitewing radiography and oral hygiene instruction.

Primary Outcome Measure

Change in Mean Relative Radiographic Density of Interproximal Carious Lesions [ Time Frame: From enrollment to the end of treatment at 3 months. Measurements will be recorded periodically at baseline, 1 week after treatment, 1 month after treatment, and 3 months after treatment. ]

Locations (1)

Find similar trials in Schofield Barracks, HI