Digital Outreach for Heart Failure Adherence

Conditions

• CHF - Congestive Heart Failure

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Digital Outreach — BEHAVIORAL
  Participants assigned to this arm will receive digital outreach encouraging refill of overdue guideline-directed medical therapy (GDMT) medications for heart failure. Participants who have opted in to pharmacy text messaging at the time of outreach will receive interactive text messages. Participants who have not opted in to pharmacy text messaging will receive an interactive automated telephone call. Participants may receive additional outreach during the 12-month intervention period if another eligible GDMT medication becomes overdue.

Study Details

The goal of the ADHERE-HF study is to evaluate whether digital outreach improves medication refill, adherence, and clinical outcomes among adults with heart failure who are overdue for a refill of an eligible guideline-directed medical therapy (GDMT) medication. The main question it aims to answer is: Does digital outreach using interactive text messages or automated telephone calls increase short-term refill of overdue heart failure medications compared with usual care? The study team, working with operational partners, will evaluate the effectiveness of a digital outreach strategy delivered through existing health system communication channels. Participants who have opted in to pharmacy text messaging will receive interactive text messages, while those who have not opted in will receive an interactive automated telephone call. The comparison group will receive usual care with no additional study-specific outreach. Participants will: * Be assigned to digital outreach or usual care * Potentially receive an interactive text message or automated telephone call encouraging refill of overdue heart failure medications * Be monitored for medication refill within 14 and 28 days * Potentially receive additional outreach if another eligible heart failure medication becomes overdue during the 12-month follow-up period * Have their medication refill patterns, longer-term adherence, hospitalizations, and mortality tracked using routinely collected health system data

Key Dates

First listed

Sep 21, 2026

Start date

Sep 21, 2026

Status verified

Aug 2026

Primary completion

Mar 31, 2027

Completion

Mar 31, 2028

Study Design

Enrollment

13,714 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Arms

• Experimental: Digital Outreach
  Participants will receive interactive text messages or automated phone calls encouraging refill of overdue heart failure medications.
• No Intervention: Usual Care
  Participants in this arm will receive usual care with no proactive outreach during the study period.

Primary Outcome Measure

Refill of at least one overdue GDMT medication (within 14 days) [ Time Frame: Within 14 days after outreach ]

Locations (1)

Find similar trials in Pleasanton, CA

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