Brain Function and Cognitive Control Training in Children With Obsessive-Compulsive Symptoms

Part of paid clinical trials in New York, New York.

Sponsor
Columbia University
Study ID
NCT07839013
Status
Not Yet Recruiting

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Conditions

  • Cognitive Control
  • Obsessive-Compulsive Symptoms

Eligibility Criteria

Sex
ALL
Age
8 Years - 12 Years
Healthy Volunteers
Not accepted

Interventions

  • Cognitive Control Training — DEVICE
    Digital, at-home cognitive training program (AKL-T01) delivered on iPad (25 minutes/day, 5 days/week) for 4 weeks. Styled as a child-friendly video game, AKL-T01 cognitive training taps skills like focused attention, response inhibition, and working memory using a series of games with individually titrated difficulty to engage cognitive control processes.

Study Details

The goal of this clinical trial is to learn about brain function and cognition in children ages 8-12 who have subclinical obsessive-compulsive symptoms (OCS), such as unwanted thoughts or repetitive behaviors. The study will also examine whether patterns of brain activity are related to how children respond to cognitive training. The main questions this study aims to answer are: * Are there different patterns of brain activity related to cognitive control among children with OCS? * Are these patterns related to differences in OCS or cognition? * Can brain activity before training help predict changes in cognitive control or OCS severity after cognitive training? Participants will: * Complete clinical interviews, questionnaires, and tests of cognition. * Have a magnetic resonance imaging scan while completing a cognitive control task. * Complete video-game-based cognitive training on an iPad for about 25 minutes a day, 5 days a week, for 4 weeks. * Complete another set of clinical interviews and questionnaires after the training.

Key Dates

First listed
Sep 24, 2026
Start date
Oct 15, 2026
Status verified
Sep 2026
Primary completion
Jun 30, 2030
Completion
Jun 30, 2030

Study Design

Enrollment
60 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Cognitive Training for Subclinical Obsessive-Compulsive Symptoms
    This is an open-label, one-arm study. Children who have subclinical obsessive-compulsive symptoms (CY-BOCS score 1-12) will complete 4-weeks of at-home cognitive training.

Primary Outcome Measure

NIH Toolbox Cognition Battery [ Time Frame: Baseline, post-cognitive training (4 weeks) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Columbia University Irving Medical CenterNew YorkNew York10032
Dana Diaz
[email protected]
(646) 774-5128

Find similar trials in New York, NY

By research site
Columbia University Irving Medical Center· New York, NY

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