Sex Hormones and Aging

Part of paid clinical trials in Ann Arbor, Michigan.

Sponsor: University of Michigan
Study ID: NCT07848438
Status: Recruiting

Apply to this trial

Conditions

Aging
Menopausal Hormone Therapy
Menopause

Eligibility Criteria

Sex: FEMALE
Age: 50 Years - 70 Years
Healthy Volunteers: Accepted

Interventions

HRT: High-Resistance Strength Training — OTHER
Each participant will attend 2 sessions per week for 8 weeks. A training session will start with a 10-minute full body dynamic warm-up (e.g., bodyweight movements and mobility exercises). The participant will then perform bilateral lower body high-resistance strength training exercises (leg extension and leg press) for 4 sets of 8-10 repetitions.
Control: High-Resistance Strength Training — OTHER
Each participant will attend 2 sessions per week for 8 weeks. A training session will start with a 10-minute full body dynamic warm-up (e.g., bodyweight movements and mobility exercises). The participant will then perform bilateral lower body high-resistance strength training exercises (leg extension and leg press) for 4 sets of 8-10 repetitions.

Study Details

This study investigates the influence of sex hormones and exercise on age-related neuromuscular decline in females. Specifically, the research aims to evaluate how hormonal variations impact both age-associated neuromuscular decline and the subsequent adaptations to exercise and resistance training. Age-related declines in neuromuscular function are especially pronounced in females, potentially due to the sharp drop in estradiol after menopause. This project will compare postmenopausal females who have not taken hormonal therapy (HT) to age-matched females taking HT.

Key Dates

First listed: Sep 30, 2026
Start date: Aug 20, 2026
Status verified: Sep 2026
Primary completion: Aug 31, 2031
Completion: Aug 31, 2031

Study Design

Enrollment: 120 participants (estimated)
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Arms

Experimental: Postmenopausal Hormone Therapy
Postmenopausal females who are currently taking hormone replacement therapy
Experimental: Postmenopausal Female Controls
Postmenopausal females who have no history of taking hormone replacement therapy