Examination of Transcranial Focused Ultrasound on Brain Activity in Adults With Cocaine Use Disorder

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Mary Phillips, MD MD (Cantab)
Study ID
NCT07852923
Status
Not Yet Recruiting

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Conditions

  • Cocaine Use Disorder (CUD)

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Not accepted

Interventions

  • tFUS — DEVICE
    tFUS is a brief stimulation of a part of the brain called the ventral striatum with low-intensity sound waves that pass through the scalp and skull safely.
  • Sham tFUS — DEVICE
    Sham tFUS goes through the motions of applying tFUS to the brain. Participants will know that one session will be a sham, but they will be blinded to which session is the sham

Study Details

The investigators aim to examine the effect of transcranial focused ultrasound (tFUS) on brain activity and cocaine craving in adults with cocaine use disorder.

Key Dates

First listed
Oct 1, 2026
Start date
Dec 15, 2026
Status verified
Sep 2026
Primary completion
Dec 15, 2028
Completion
Dec 15, 2028

Study Design

Enrollment
57 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: VS tFUS/Sham tFUS
    VS tFUS (tFUS applied to the ventral striatum); Sham tFUS (go through the motions of applying tFUS to the VS)
  • Experimental: Sham tFUS/VS tFUS
    Sham tFUS (go through the motions of applying tFUS to the VS); VS tFUS (tFUS applied to the ventral striatum)

Primary Outcome Measure

Ventral striatum (VS) activity to cocaine cues before receiving tFUS to the VS [ Time Frame: Two visits over up to 8 weeks ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of PittsburghPittsburghPennsylvania15213
Research Coordinator
[email protected]

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By research site
University of Pittsburgh· Pittsburgh, PA

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