Use of Preoperative Gas in Eyes With Macula-off Rhegmatogenous Retinal Detachment (RRD)

Conditions

• Retinal Detachment Rhegmatogenous

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Intravitreal 100% C3F8 Injection — PROCEDURE
  Patients with Macula off Rhegmatogenous Retinal Detachment will receive an intravitreal injection of 100% C3F8 prior to undergoing surgical repair for their condition
• Pars plana vitrectomy or pars plana vitrectomy with scleral buckle — PROCEDURE
  Patients with RRD will undergo standard of care treatment of RRD with pars plana vitrectomy or pars plana vitrectomy with scleral buckle

Study Details

The purpose of this study is to evaluate whether a preoperative intraocular gas injection improves visual outcomes in patients with a macula-off rhegmatogenous retinal detachment (RRD). While current surgical therapies successfully reattach the retina, visual recovery can vary. This study will investigate if injecting a small amount of gas (0.3 cc of 100% C3F8) into the eye prior to standard surgery can decrease the duration of macular detachment, reduce retinal displacement, and ultimately result in better final visual acuity compared to the standard of care alone.

Key Dates

First listed

Oct 2, 2026

Start date

Sep 21, 2026

Status verified

Sep 2026

Primary completion

Sep 30, 2028

Completion

Mar 31, 2029

Study Design

Enrollment

190 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Preoperative Gas
  Patients in this group will be injected with 0.3 cc of 100% C3F8 gas prior to surgical repair of the retinal detachment.
• Active Comparator: Standard of Care
  Patients in this arm will receive standard of care treatment with Pars Plana Vitrectomy or Pars Plana vitrectomy with Scleral Buckle.

Primary Outcome Measure

Visual Acuity [ Time Frame: 6 months ]

Central Contacts

• Omar Masoud, MD
  4452133130
  [email protected]
• Zainab Rustam, MD
  6674147808
  [email protected]

Locations (2)

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