Intismeran autogene Clinical Trials (2026): 12 Studies for Non-small Cell Lung Cancer & Melanoma

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

12 Intismeran autogene clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 10 indications (including Non-small Cell Lung Cancer & Melanoma) and 5,137 total planned enrollment. 4 Phase 3 Intismeran autogene trials and 5 Phase 2 are listed. 5 Intismeran autogene clinical trials are actively recruiting at 105 U.S. sites across 30 states. Most recent activity: NCT07513376 (May 2038).

Where to Participate: All Intismeran autogene Trial Sites in the U.S. (105 sites across 30 states)

Every actively recruiting Intismeran autogenetrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
AZBanner MD Anderson Cancer Center ( Site 0181)Gilbert85234NCT06623422Map
AZThe University of Arizona Cancer Center - North Campus ( Site 0163)Tucson85719NCT06623422Map
ARHighlands Oncology Group ( Site 4042)Springdale72762NCT06961006Map
CAMichael G Oefelein Clinical Trials ( Site 0138)Bakersfield93301NCT06833073Map
CAProvidence St. Jude Medical Center ( Site 0106)Fullerton92835NCT06623422Map
CAVA Long Beach Healthcare System ( Site 0199)Long Beach90822NCT06623422Map
CAUCLA Jonsson Comprehensive Cancer Center ( Site 0135)Los Angeles90404NCT06623422Map
CAUSC Norris Comprehensive Cancer Center ( Site 0123)Los Angeles90033NCT06833073Map
CAUSC Norris Comprehensive Cancer Center ( Site 0205)Los Angeles90033NCT06623422Map
CAUC Davis Comprehensive Cancer Center ( Site 3204)Sacramento95817NCT07513376Map
CAUCSF Medical Center at Mission Bay ( Site 0178)San Francisco94158NCT06623422Map
CAUCSF Medical Center at Mission Bay ( Site 4044)San Francisco94158NCT06961006Map
CAGenesis Healthcare-Torrance ( Site 0140)Torrance90503NCT06833073Map
CAGenesis Research LLC ( Site 0118)Torrance90505NCT06833073Map
COUniversity of Colorado Anschutz Medical Campus ( Site 0151)Aurora80045NCT06623422Map
COUniversity of Colorado Cancer Center ( Site 3268)Aurora80045NCT07513376Map
COUCHealth Memorial Hospital Central ( Site 0125)Colorado Springs80909NCT06623422Map
COBanner MD Anderson Cancer Center at North Colorado Medical Center ( Site 0207)Greeley80631NCT06623422Map
COUrology Associates ( Site 0144)Littleton80122NCT06833073Map
COCentura Health - St. Anthony North Health Campus ( Site 0189)Westminster80023NCT06623422Map
CTSmilow Cancer Center at Yale-New Haven ( Site 3253)New Haven06511NCT07513376Map
CTYale University School of Medicine ( Site 0201)New Haven06510NCT06623422Map
CTEastern CT Hematology & Oncology Associates ( Site 0202)Norwich06360NCT06623422Map
FLThe Oncology Institute of Hope and Innovation - Fort Lauderdale ( Site 0156)Fort Lauderdale33316NCT06623422Map
FLUrological Research Network ( Site 0133)Hialeah33016NCT06833073Map
FLMiami Cancer Institute at Baptist Health, Inc. ( Site 0214)Miami33176NCT06623422Map
FLMoffitt Cancer Center ( Site 0021)Tampa33612NCT07221474Map
IDBeacon Cancer Care ( Site 0127)Post Falls83854NCT06623422Map
ILThe University of Chicago Medical Center ( Site 0118)Chicago60637NCT06623422Map
ILAssociated Urological Specialists - Chicago Ridge ( Site 0139)Chicago Ridge60415NCT06833073Map
ILIllinois Cancer Care ( Site 7000)Peoria61615NCT07513376Map
INFranciscan Health ( Site 0219)Indianapolis46237NCT06623422Map
LASouthern Urology, LLC ( Site 0145)Lafayette70508NCT06833073Map
MDMaryland Oncology Hematology (MOH) ( Site 8102)Rockville20850NCT06623422Map
MADana Farber Cancer Hospital ( Site 0155)Boston02215NCT06623422Map
MAMassachusetts General Hospital ( Site 0136)Boston02114NCT06623422Map
MIVA Ann Arbor Healthcare System ( Site 0019)Ann Arbor48105NCT07221474Map
MOUniversity of Missouri Health Care ( Site 0126)Columbia65212NCT06833073Map
MOWashington University School of Medicine ( Site 0024)St Louis63110NCT07221474Map
MTBillings Clinic ( Site 3255)Billings59101NCT07513376Map
NENHO Revive Research Institute, LLC ( Site 0137)Lincoln68506NCT06833073Map
NENHO Revive Research Institute, LLC ( Site 3218)Lincoln68506NCT07513376Map
NVRenown Regional Medical Center-Renown Health Medical Oncology ( Site 3207)Reno89502NCT07513376Map
NJJohn Theurer Cancer Center at Hackensack University Medical Center ( Site 4047)Hackensack07601NCT06961006Map
NJValley Health Systems - Ridgewood Campus ( Site 0010)Paramus07652NCT07221474Map
NYNew York Oncology Hematology (NYOH) - Albany Medical Center ( Site 9001)Albany12206NCT07221474Map
NYNew York Oncology Hematology, P.C. ( Site 9000)Albany12206NCT07513376Map
NYRoswell Park Cancer Institute ( Site 0184)Buffalo14263NCT06623422Map
NYHematology-Oncology Associates of CNY ( Site 0164)East Syracuse13057NCT06623422Map
NYIcahn School of Medicine at Mount Sinai ( Site 0116)New York10029NCT06623422Map
NYLaura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0111)New York10016NCT06833073Map
NYMemorial Sloan Kettering Cancer Center ( Site 0137)New York10065NCT06623422Map
NYThe Blavatnik Family- Chelsea Medical Center at Mount Sinai ( Site 0216)New York10011NCT06623422Map
NYSUNY Upstate Cancer Center ( Site 0140)Syracuse13210NCT06623422Map
NYMontefiore Medical Center ( Site 0160)The Bronx10461NCT06623422Map
NYWestchester Medical Center ( Site 0196)Valhalla10595NCT06623422Map
NYWhite Plains Hospital ( Site 3213)White Plains10601NCT07513376Map
NCCharles George VA Medical Center ( Site 3233)Asheville28805NCT07513376Map
NCUNC Lineberger Comprehensive Cancer Center ( Site 3250)Chapel Hill27514NCT07513376Map
NCNovant Health Weisiger Cancer Insititute ( Site 0266)Charlotte28204NCT06623422Map
NCWakeMed Raleigh Campus ( Site 3214)Raleigh27610NCT07513376Map
NCNovant Health Forsyth Medical Center ( Site 0166)Winston-Salem27103NCT06623422Map
NDSanford Fargo Medical Center ( Site 3236)Fargo58102NCT07513376Map
NDAltru Health System ( Site 3254)Grand Forks58201NCT07513376Map
OHTriState Urologic Services PSC Inc. dba The Urology Group ( Site 0122)Cincinnati45212NCT06833073Map
OHUniversity of Cincinnati Medical Center ( Site 0119)Cincinnati45219NCT06623422Map
OHCleveland Clinic - Ohio ( Site 0016)Cleveland44195NCT07221474Map
ORGood Samaritan Regional Medical Center-Samaritan Pastega Regional Cancer Center ( Site 0025)Corvallis97330NCT07221474Map
ORGood Samaritan Regional Medical Center-Samaritan Pastega Regional Cancer Center ( Site 0217)Corvallis97330NCT06623422Map
OROHSU Knight Cancer Institute - South Waterfront ( Site 0110)Portland97239NCT06833073Map
PAMidLantic Urology ( Site 0102)Bala-Cynwyd19004NCT06833073Map
PASt. Lukes Hospital and Health Network ( Site 0186)Bethlehem18015NCT06623422Map
PAPerelman Center for Advanced Medicine ( Site 3205)Philadelphia19104NCT07513376Map
SDAvera Cancer Institute ( Site 3209)Sioux Falls57105NCT07513376Map
SDSanford Cancer Center ( Site 3266)Sioux Falls57104NCT07513376Map
TNTennessee Oncology, PLLC - Chattanooga Downtown ( Site 0315)Chattanooga37403NCT06623422Map
TNThe Conrad Pearson Clinic ( Site 0143)Germantown38138NCT06833073Map
TNThe University of Tennessee Medical Center ( Site 3223)Knoxville37920NCT07513376Map
TNThompson Cancer Survival Center ( Site 0168)Knoxville37916NCT06623422Map
TNElliston Place Medical Oncology & Hematology ( Site 0215)Nashville37203NCT06623422Map
TNTennessee Oncology, PLLC - Elliston Place Plaza Medical Oncology & Hematology ( Site 9000)Nashville37203NCT07221474Map
TXTexas Oncology - Central/South Texas ( Site 8002)Austin78745NCT07221474Map
TXTexas Oncology-Austin Central ( Site 0107)Austin78705NCT06833073Map
TXUrology Austin, PLLC ( Site 0109)Austin78759NCT06833073Map
TXTexas Oncology - DFW ( Site 8103)Dallas75246NCT06623422Map
TXUT Southwestern Medical Center ( Site 0190)Dallas75390NCT06623422Map
TXHouston Methodist Cancer Center ( Site 0191)Houston77030NCT06623422Map
TXMD Anderson Cancer Center ( Site 0150)Houston77030NCT06623422Map
TXMemorial Hermann Cancer Center ( Site 0172)Houston77030NCT06623422Map
TXMichael E. DeBakey VA Medical Center ( Site 0197)Houston77030NCT06623422Map
TXO'Quinn Medical Tower at McNair Campus ( Site 0131)Houston77030NCT06623422Map
TXThe University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0148)Tyler75701NCT06623422Map
VAInova Schar Cancer Institute ( Site 4046)Fairfax22031NCT06961006Map
VAVirginia Cancer Specialists ( Site 0003)Fairfax22031NCT07221474Map
VAVirginia Cancer Specialists ( Site 0167)Fairfax22031NCT06623422Map
VAHematology Oncology Associates of Fredericksburg ( Site 3275)Fredericksburg22408NCT07513376Map
VAVirginia Oncology Associates (VOA) ( Site 8101)Norfolk23502NCT06623422Map
VAVCU Health Adult Outpatient Pavillion ( Site 0193)Richmond23219NCT06623422Map
VAUrology of Virginia ( Site 0125)Virginia Beach23462NCT06833073Map
WAFred Hutchinson Cancer Center ( Site 4041)Seattle98109NCT06961006Map
WASwedish Cancer Institute ( Site 0143)Seattle98104NCT06623422Map
WASwedish Medical Center-Swedish Cancer Institute ( Site 0023)Seattle98104NCT07221474Map
WAUniversity of Washington - Fred Hutchinson Cancer Center ( Site 0100)Seattle98195NCT06833073Map
WASt. Joseph Medical Center Hematology and Oncology - Silverdale ( Site 0192)Silverdale98383NCT06623422Map
WVWest Virginia University ( Site 3237)Morgantown26506NCT07513376Map

Intismeran autogene clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingterminatedTotal
P111
P1/P211
P2325
P2/P311
P3224

Recruiting Intismeran autogene clinical trials (5)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07513376INTerpath-014A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)P3Non-small Cell Lung Cancer876May 2026
NCT06623422MK-3475A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)P3Carcinoma, Non-Small-Cell Lung680Oct 2024
NCT06961006V940A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)P2Malignant Melanoma160May 2025
NCT06833073V940A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)P2Urinary Bladder Neoplasms308Mar 2025
NCT07221474INTerpath-13A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)P2Squamous Non-small Cell Lung Cancer180Dec 2025

Intismeran autogene clinical trials by indication

Melanoma (2)

NCTAcronymPhaseStatusTitle
NCT03897881KEYNOTE-942P2active not recruitingAn Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942)
NCT05933577V940P3active not recruitingA Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)

Non-small Cell Lung Cancer (2)

NCTAcronymPhaseStatusTitle
NCT07513376INTerpath-014P3recruitingA Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)
NCT06077760INTerpath-002P3active not recruitingA Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)

Solid Tumors (1)

NCTAcronymPhaseStatusTitle
NCT03313778KEYNOTE-603P1active not recruitingSafety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid Tumors

Carcinoma, Squamous Cell (1)

NCTAcronymPhaseStatusTitle
NCT06295809INTerpath-007P2/P3terminatedA Study of (Neo)Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Cutaneous Squamous Cell Carcinoma (V940-007)

Bladder Cancer (1)

NCTAcronymPhaseStatusTitle
NCT06305767V940P1/P2active not recruitingA Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)

Renal Cell Carcinoma (1)

NCTAcronymPhaseStatusTitle
NCT06307431INTerpath-004P2active not recruitingA Study of Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Renal Cell Carcinoma (V940-004).

Carcinoma, Non-Small-Cell Lung (1)

NCTAcronymPhaseStatusTitle
NCT06623422MK-3475P3recruitingA Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

Urinary Bladder Neoplasms (1)

NCTAcronymPhaseStatusTitle
NCT06833073V940P2recruitingA Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)

Malignant Melanoma (1)

NCTAcronymPhaseStatusTitle
NCT06961006V940P2recruitingA Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)

Squamous Non-small Cell Lung Cancer (1)

NCTAcronymPhaseStatusTitle
NCT07221474INTerpath-13P2recruitingA Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)

Intismeran autogene pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
INTerpath-014NCT07513376P3recruitingNon-small Cell Lung Cancer876—
MK-3475NCT06623422P3recruitingCarcinoma, Non-Small-Cell Lung680—
INTerpath-002NCT06077760P3active not recruitingNon-small Cell Lung Cancer868—
V940NCT05933577P3active not recruitingMelanoma1,089—
KEYNOTE-942NCT03897881P2active not recruitingMelanoma267—
INTerpath-004NCT06307431P2active not recruitingRenal Cell Carcinoma272—
V940NCT06961006P2recruitingMalignant Melanoma160—
V940NCT06833073P2recruitingUrinary Bladder Neoplasms308—
INTerpath-13NCT07221474P2recruitingSquamous Non-small Cell Lung Cancer180—

Terminated and withdrawn Intismeran autogene trials (1)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

  • NCT06295809terminatedA Study of (Neo)Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Cutaneous Squamous Cell Carcinoma (V940-007)

All Intismeran autogene trials (12)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07513376INTerpath-014A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)P3recruiting876Merck Sharp & Dohme LLCMay 2026
NCT06623422MK-3475A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)P3recruiting680Merck Sharp & Dohme LLCOct 2024
NCT06077760INTerpath-002A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)P3active not recruiting868Merck Sharp & Dohme LLCDec 2023
NCT03897881KEYNOTE-942An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942)P2active not recruiting267ModernaTX, Inc.Jul 2019
NCT06307431INTerpath-004A Study of Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Renal Cell Carcinoma (V940-004).P2active not recruiting272Merck Sharp & Dohme LLCApr 2024
NCT06305767V940A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)P1/P2active not recruiting230Merck Sharp & Dohme LLCMar 2024
NCT06961006V940A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)P2recruiting160Merck Sharp & Dohme LLCMay 2025
NCT06833073V940A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)P2recruiting308Merck Sharp & Dohme LLCMar 2025
NCT07221474INTerpath-13A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)P2recruiting180Merck Sharp & Dohme LLCDec 2025
NCT05933577V940A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)P3active not recruiting1,089Merck Sharp & Dohme LLCJul 2023
NCT03313778KEYNOTE-603Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid TumorsP1active not recruiting161ModernaTX, Inc.Aug 2017
NCT06295809INTerpath-007A Study of (Neo)Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Cutaneous Squamous Cell Carcinoma (V940-007)P2/P3terminated46Merck Sharp & Dohme LLCApr 2024

Intismeran autogene clinical trials: frequently asked questions

How many Intismeran autogene clinical trials are there?
12 Intismeran autogene clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 5 are actively recruiting participants.
Are Intismeran autogene clinical trials recruiting in 2026?
Yes — 5 Intismeran autogene trials are actively recruiting in 2026, with 105 U.S. sites across 30 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Intismeran autogene being studied for?
Intismeran autogene is being studied for Non-small Cell Lung Cancer, Melanoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Malignant Melanoma and 8 more. The trials are grouped by indication on this page.
What phase is Intismeran autogene in?
Intismeran autogene clinical trials span 4 Phase 3, 5 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Intismeran autogene clinical trials?
The lead sponsor across the most Intismeran autogene trials is Merck Sharp & Dohme LLC, with 1 additional lead sponsor listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Intismeran autogeneas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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