How many KarXT clinical trials are there?

25 KarXT clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 18 are actively recruiting participants. 3 are marked completed.

Are KarXT clinical trials recruiting in 2026?

Yes — 18 KarXT trials are actively recruiting in 2026, with 287 U.S. sites across 31 states. See the recruiting trials and the per-state site list further down this page.

What conditions is KarXT being studied for?

KarXT is being studied for Schizophrenia, Psychosis Associated With Alzheimer's Disease, Alzheimer Disease, Irritability Associated With Autism Spectrum Disorder, Alzheimer's Disease and 15 more. The trials are grouped by indication on this page.

What phase is KarXT in?

KarXT clinical trials span 17 Phase 3, 4 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.

Who sponsors KarXT clinical trials?

The lead sponsor across the most KarXT trials is Bristol-Myers Squibb, with 3 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

KarXT Clinical Trials (2026): 25 Studies for Schizophrenia & Psychosis Associated With Alzheimer's Disease

Creator: Hipa.ai Research
Published: 2026-06-02T17:08:59.819Z

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: July 17, 2026.

25 KarXT clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 12 indications (including Schizophrenia & Psychosis Associated With Alzheimer's Disease) and 15,518 total planned enrollment. 17 Phase 3 KarXT trials are listed. 21 KarXT clinical trials are actively recruiting at 287 U.S. sites across 31 states. Most recent activity: NCT07228338 (Oct 2031).

Where to Participate: All KarXT Trial Sites in the U.S. (287 sites across 31 states)

Every actively recruiting KarXTtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

State	Facility	City	Trial	Map
AZ	Gilbert Neurology Partners - PLLC - Avacare	Gilbert85297	NCT06585787	Map
AZ	Gilbert Neurology Partners/CCT Research	Gilbert85297	NCT06947941	Map
AZ	Banner Alzheimer's Institute	Phoenix85006-2528	NCT06585787	Map
AZ	Imaging Endpoints	Scottsdale85258	NCT06937229	Map
AR	Pillar Clinical Research - Bentonville	Bentonville72712	NCT06951698	Map
AR	Pillar Clinical Research - Richardson	Bentonville72712	NCT06929273	Map
AR	SanRo Clinical Research Group	Bryant72022	NCT07379827	Map
AR	Pillar Clinical Research- Little Rock	Little Rock72204	NCT06929273	Map
AR	Pillar Clinical Research- Little Rock	Little Rock72204	NCT06951711	Map
AR	Woodland International Research Group	Little Rock72211	NCT06929273	Map
AR	Woodland International Research Group	Little Rock72211	NCT06951698	Map
AR	Woodland Research Northwest	Rogers72758	NCT06929273	Map
AR	Woodland Research Northwest	Rogers72758	NCT06951711	Map
CA	Advanced Research Center Inc.	Anaheim92805	NCT07288567	Map
CA	Advanced Research Center Inc.	Anaheim92805	NCT06929273	Map
CA	Advanced Research Center Inc.	Anaheim92805	NCT07424404	Map
CA	Advanced Research Center Inc.	Anaheim92805	NCT06951698	Map
CA	Advanced Research Center, Inc.	Anaheim92805-5854	NCT05980949	Map
CA	Advanced Research Center, Inc.	Anaheim92805-5854	NCT06585787	Map
CA	CITrials	Bellflower90706	NCT06951698	Map
CA	Clinical Innovations, Inc. dba CITrials	Bellflower90706	NCT06929273	Map
CA	Inland Psychiatric Medical Group - Chino	Chino91710	NCT06929273	Map
CA	Inland Psychiatric Medical Group (IPMG)-Chino	Chino91710	NCT06585787	Map
CA	Inland Psychiatric Medical Group.	Chino91710	NCT07288567	Map
CA	Inland Psychiatric Medical Group.	Chino91710	NCT07424404	Map
CA	Inland Psychiatric Medical Group.	Chino91710	NCT06947941	Map
CA	Proscience Research Group	Culver City90230	NCT06929273	Map
CA	Proscience Research Group	Culver City90230	NCT06951711	Map
CA	Fullerton Neurology and Headache Center	Fullerton92835	NCT06976203	Map
CA	Collaborative Neuroscience Research, LLC	Garden Grove92845-2506	NCT06929273	Map
CA	Inglewood Clinical	Inglewood90301	NCT06976203	Map
CA	Irvine Clinical Research	Irvine92614	NCT06976203	Map
CA	Omega Clinical Trials - La Habra	La Habra90631	NCT06929273	Map
CA	Collaborative Neuroscience Research, LLC	Long Beach90806	NCT06951698	Map
CA	Healthy Brain Clinic	Long Beach90804	NCT06976216	Map
CA	Collaborative Neuroscience Research, LLC	Los Alamitos90720-3118	NCT07061288	Map
CA	USC - The Memory and Aging Center (MAC) - Alzheimer Disease Research Center (ADRC)	Los Angeles90033-5313	NCT05980949	Map
CA	USC - The Memory and Aging Center (MAC) - Alzheimer Disease Research Center (ADRC)	Los Angeles90033-5313	NCT06585787	Map
CA	Catalina Research Institute, LLC	Montclair91763	NCT06929273	Map
CA	Catalina Research Institute, LLC	Montclair91763	NCT06951698	Map
CA	ATP Clinical Research-302 W La Veta Ave	Orange92866	NCT05511363	Map
CA	NRC Research Institute	Orange92868	NCT06929273	Map
CA	NRC Research Institute	Orange92868	NCT06951698	Map
CA	SC3 Research - Pasadena - 960 E. Green St	Pasadena91106	NCT05980949	Map
CA	Anderson Clinical Research	Redlands92374	NCT06976216	Map
CA	Clinical Innovations, Inc. dba CITrials	Riverside92506	NCT06929273	Map
CA	Clinical Innovations, Inc. dba CITrials	Riverside92506	NCT06951711	Map
CA	Collaborative Neuroscience Research, LLC	Torrance90504	NCT06929273	Map
CA	Collaborative Neuroscience Research, LLC	Torrance90502	NCT06951711	Map
CA	Sunwise Clinical Research, LLC - Walnut Creek - IVY - PPDS	Walnut Creek94596	NCT05511363	Map
CA	Sunwise Clinical Research, LLC - Walnut Creek - IVY - PPDS	Walnut Creek94596	NCT05980949	Map
CO	Mountain Neurological Research Center	Basalt81621	NCT06976216	Map
CO	Research of the Rockies	Colorado Springs80919	NCT06976203	Map
CT	University of Connecticut Health Center	Farmington06030	NCT05980949	Map
CT	University of Connecticut Health Center	Farmington06030	NCT06585787	Map
CT	Connecticut Mental Health Center	New Haven06519	NCT06951698	Map
CT	Yale New Haven Hospital-Smilow Cancer Center	New Haven06510	NCT06929273	Map
DC	Georgetown University Medical Center	Washington D.C.20007	NCT06976216	Map
FL	JEM Research Institute	Atlantis33462	NCT06976216	Map
FL	VIN-Julie Schwartzbard	Aventura33180	NCT06976216	Map
FL	Envision Trials LLC	Bonita Springs34134	NCT05980949	Map
FL	Envision Trials LLC	Bonita Springs34134	NCT06585787	Map
FL	Envision Trials LLC	Bonita Springs34134	NCT07379827	Map
FL	K2 Medical Research - Winter Garden	Clermont34711-5933	NCT05511363	Map
FL	K2 Medical Research - Winter Garden	Clermont34711-5933	NCT05980949	Map
FL	JY Research Institute Inc	Cutler Bay33189-1230	NCT05980949	Map
FL	Arrow Clinical Trials	Daytona Beach32117-5532	NCT05511363	Map
FL	Arrow Clinical Trials	Daytona Beach32117-5532	NCT05980949	Map
FL	Arrow Clinical Trials	Daytona Beach32117-5532	NCT06585787	Map
FL	Betancourt Research Services	Doral33172-2638	NCT05980949	Map
FL	Integrity Clinical Research LLC - 21st Street	Doral33122-1620	NCT05980949	Map
FL	Neuropsychiatric Research Center of Southwest Florida	Fort Myers33912	NCT06976203	Map
FL	Velocity Clinical Research, Hallandale Beach	Hallandale33009	NCT06929273	Map
FL	Direct Helpers Research Center	Hialeah33012-3618	NCT05980949	Map
FL	Galiz Research	Hialeah33016-1814	NCT05980949	Map
FL	Galiz Research	Hialeah33016-1814	NCT07379827	Map
FL	Las Mercedes Medical Research - 4440 West 16th Ave	Hialeah33012	NCT05980949	Map
FL	New Life Medical Research Center -3750 W 16th Ave	Hialeah33012-4648	NCT05980949	Map
FL	Behavioral Clinical Research	Hollywood33021	NCT06929273	Map
FL	Behavioral Clinical Research	Hollywood33021	NCT06951711	Map
FL	Research Centers of America ( Hollywood )	Hollywood33024	NCT06929273	Map
FL	Research Centers of America ( Hollywood )	Hollywood33024	NCT06951698	Map
FL	Research Centers of America ( Hollywood )	Hollywood33024	NCT07061288	Map
FL	Advanced Research Institute of Miami	Homestead33033	NCT06951698	Map
FL	Coral Clinic Research	Homestead33032	NCT05980949	Map
FL	Homestead Associates in Research Inc-30328 Old Dixie Hwy	Homestead33033	NCT05980949	Map
FL	Nexus Clinical Research Center- NRC	Homestead33030	NCT05980949	Map
FL	Jacksonville Center for Clinical Research	Jacksonville32216	NCT06976203	Map
FL	New Access Research & Medical Services Inc - Kendall	Kendall33186	NCT07379827	Map
FL	K2 MEDICAL Research THE VILLAGES	Lady Lake32159	NCT06976203	Map
FL	K2 Medical Research - Maitland	Maitland32751-5669	NCT05511363	Map
FL	K2 Medical Research - Maitland	Maitland32751-5669	NCT05980949	Map
FL	Merritt Island Medical Research, LLC	Merritt Island32952	NCT06976216	Map
FL	A & D Doctor Center	Miami33135-2968	NCT05980949	Map
FL	Advanced Research Institute of Miami	Miami33135	NCT06929273	Map
FL	Allied Biomedical Research Institute	Miami33155-4630	NCT05980949	Map
FL	Angels Clinical Research Institute - Miami	Miami33122-1721	NCT05980949	Map
FL	Banyan Behavioal Care Program - CSU	Miami33134	NCT07379827	Map
FL	BioResearch Partner - Miami	Miami33175	NCT07379827	Map
FL	CCM Clinical Research Group	Miami33133-4231	NCT05980949	Map
FL	Coral Research Clinic & Coral Diagnostic Center	Miami33186-4643	NCT05980949	Map
FL	Dade Research Center - Miami FL - 7600 SW 87th Ave	Miami33173	NCT05980949	Map
FL	Florida Research Center, Inc.	Miami33174-2950	NCT05980949	Map
FL	Floridian Neuroscience Institute-1901 SW 1 St	Miami33135	NCT05980949	Map
FL	Future Care Solution LLC	Miami33165-3947	NCT05980949	Map
FL	High Quality Research	Miami33184-1412	NCT05980949	Map
FL	IMIC LLC- 9380 SW 150th Str	Miami33176-7947	NCT05980949	Map
FL	LCC Medical Research Institute	Miami33126	NCT06929273	Map
FL	LCC Medical Research Institute	Miami33126	NCT06951711	Map
FL	MedOne Clinical Research LLC	Miami33145-2455	NCT05980949	Map
FL	My Community Research Center, Inc - 7480 Bird Rd	Miami33155-6630	NCT05980949	Map
FL	New Gen Health	Miami33176	NCT05980949	Map
FL	Novel Clinical Research Center, LLC -7000 SW 97th Ave	Miami33173-1474	NCT05980949	Map
FL	Nuovida Research Center	Miami33186	NCT06937229	Map
FL	ONHEALTH Research Center	Miami33186-5882	NCT05980949	Map
FL	Premier Clinical Research Institute	Miami33122-1335	NCT05980949	Map
FL	Reliant Medical Research	Miami33165	NCT05980949	Map
FL	Serenity Research Center	Miami33176-1451	NCT05980949	Map
FL	South Florida Research Phase I-IV	Miami33166	NCT06951698	Map
FL	South Florida Research Phase I-IV, Inc. - Miami	Miami33166	NCT05980949	Map
FL	Wellness Research Center Inc - Miami	Miami33135-1601	NCT05980949	Map
FL	New Med Research	Miami Gardens33056-4000	NCT05980949	Map
FL	Innovative Clinical Research, Inc.	Miami Lakes33016	NCT06929273	Map
FL	Innovative Clinical Research, Inc.	Miami Lakes33016	NCT06951711	Map
FL	Innovative Clinical Research, Inc.	Miami Lakes33016	NCT06951698	Map
FL	Innovative Clinical Research, Inc.	Miami Lakes33016	NCT07061288	Map
FL	Meridian International Research	Miami Lakes33014-6435	NCT05980949	Map
FL	San Marcus Research Clinic Inc	Miami Lakes33014-5602	NCT05980949	Map
FL	Ocean Blue Medical Research Center Inc	Miami Springs33166-5260	NCT05980949	Map
FL	South Florida Research Phase I-IV	Miami Springs33166	NCT06929273	Map
FL	South Florida Research Phase I-IV	Miami Springs33166	NCT06951711	Map
FL	Aqualane Clinical Research	Naples34105	NCT06585787	Map
FL	Renstar Medical Research	Ocala34470	NCT06976216	Map
FL	Sensible HealthCare, LLC	Ocoee34761-2964	NCT06585787	Map
FL	Medical Research of Central Florida	Orange City32763	NCT07379827	Map
FL	Apg Research, Llc	Orlando32803	NCT07288567	Map
FL	Apg Research, Llc	Orlando32803	NCT07424404	Map
FL	Combined Research Orlando Phase I-IV LLC	Orlando32807-3555	NCT05980949	Map
FL	Combined Research Orlando Phase I-IV LLC	Orlando32807-3555	NCT06585787	Map
FL	Nova Psychiatry	Orlando32803	NCT05980949	Map
FL	Nova Psychiatry	Orlando32803	NCT06585787	Map
FL	Neurology Associates of Ormond Beach	Ormond Beach32174-3101	NCT05980949	Map
FL	Progressive Medical Research	Port Orange32127	NCT06937229	Map
FL	Intercoastal Medical Group	Sarasota34239	NCT06976203	Map
FL	Alzheimer's Research and Treatment Center	Stuart34996	NCT06976216	Map
FL	Health Synergy Clinical Research,LLC - Stuart	Stuart34994	NCT06126224	Map
FL	Angels Clinical Research Institute Tampa - Palm Springs - PPDS	Tampa33614-2869	NCT05980949	Map
FL	Guardian Angel Research	Tampa33614	NCT05980949	Map
FL	Guardian Angel Research	Tampa33614	NCT06585787	Map
FL	Interventional Psychiatry of Tampa Bay	Tampa33629-5837	NCT05980949	Map
FL	Interventional Psychiatry of Tampa Bay	Tampa33629-5837	NCT06585787	Map
FL	IPTB Clinical Research	Tampa33629	NCT06937229	Map
FL	University of South Florida	Tampa33606	NCT05511363	Map
FL	USF Health Byrd Alzheimer's Institute	Tampa33613	NCT06976203	Map
FL	Charter Research	The Villages32162-2698	NCT06585787	Map
FL	Charter Research - Lady Lake	The Villages32162	NCT06976216	Map
FL	Local Institution - 1131	Viera32940	NCT06126224	Map
FL	Hope Research Network - Miami	Virginia Gardens33166	NCT06937229	Map
FL	Alzheimer's Research and Treatment Center	Wellington33414	NCT06976203	Map
FL	Health Synergy Clinical Research	West Palm Beach33407	NCT06929273	Map
FL	Health Synergy Clinical Research	West Palm Beach33407	NCT06951711	Map
FL	Health Synergy Clinical Research	West Palm Beach33407	NCT06951698	Map
FL	Premiere Research Institute at Palm Beach Neurology, PA	West Palm Beach33407-3209	NCT05980949	Map
FL	Premiere Research Institute at Palm Beach Neurology, PA	West Palm Beach33407-3209	NCT06585787	Map
GA	Agile Clinical Research Trials, LLC	Atlanta30328-5532	NCT05980949	Map
GA	Agile Clinical Research Trials, LLC	Atlanta30328-5532	NCT06585787	Map
GA	Atlanta Center for Medical Research	Atlanta30331	NCT07288567	Map
GA	Atlanta Center for Medical Research	Atlanta30331	NCT06929273	Map
GA	Atlanta Center for Medical Research	Atlanta30331	NCT06951711	Map
GA	Atlanta Center for Medical Research	Atlanta30331	NCT07424404	Map
GA	Atlanta Center for Medical Research	Atlanta30331	NCT07061288	Map
GA	Synexus Clinical Research US, Inc.	Atlanta30328	NCT06929273	Map
GA	Synexus Clinical Research US, Inc.	Atlanta30328	NCT06951698	Map
GA	CenExel iResearch, LLC	Decatur30030	NCT06929273	Map
GA	CenExel iResearch, LLC	Decatur30030	NCT06951711	Map
GA	CenExel iResearch, LLC	Decatur30030	NCT07061288	Map
GA	Center for Advanced Research & Education	Gainesville30501	NCT06976216	Map
GA	Salveo Integrative Health - Lawrenceville	Lawrenceville30046	NCT07288567	Map
GA	Salveo Integrative Health - Lawrenceville	Lawrenceville30046	NCT07424404	Map
GA	CenExel iResearch, LLC	Savannah31405	NCT06929273	Map
GA	CenExel iResearch, LLC	Savannah31405	NCT06951698	Map
GA	Denali Health Atlanta, LLC	Stone Mountain30083	NCT07288567	Map
GA	Denali Health Atlanta, LLC	Stone Mountain30083	NCT07424404	Map
IL	EmVenio Research Center - Prime Healthcare	Chicago60622	NCT07288567	Map
IL	EmVenio Research Center - Prime Healthcare	Chicago60622	NCT07424404	Map
IL	Great Lakes Clinical Trials - Andersonville	Chicago60640	NCT06976203	Map
IL	Pillar Clinical Research -Chicago	Chicago60641	NCT06929273	Map
IL	Pillar Clinical Research -Chicago	Chicago60641	NCT06951698	Map
IL	Re:Cognition Health - Chicago	Chicago60611	NCT06976216	Map
IL	Uptown Research Institute	Chicago60640	NCT07061288	Map
IL	Ascension Alexian Brothers	Elk Grove Village60007	NCT06976216	Map
IL	Southern Illinois University School of Medicine	Springfield62702	NCT06976203	Map
IN	Josephson Wallack Munshower Neurology, PC	Indianapolis46256	NCT06976203	Map
KS	ICON - Lenexa	Lenexa66219-9746	NCT07118215	Map
MD	CBH Health	Gaithersburg20877	NCT06929273	Map
MD	CBH Health	Gaithersburg20877	NCT06951711	Map
MA	McLean Hospital	Belmont02478-1064	NCT06585787	Map
MA	Tufts Medical Center - 800 Washington St - PPDS	Boston02111-1552	NCT06585787	Map
MA	Boston Center for Memory	Newton02459	NCT06976216	Map
MA	Boston Center for Memory	Newton02459	NCT06937229	Map
MA	Boston Neuro Research Center	North Dartmouth02747-2612	NCT06585787	Map
MA	Elixia Health - Springfield - Elixia - PPDS	Springfield01103	NCT06585787	Map
MI	Neurobehavioral Medicine Group (NBMG)	Bloomfield Township48302-1909	NCT06585787	Map
MI	QUEST Research Institute	Farmington Hills48334	NCT06976203	Map
MN	HealthPartners Neuroscience Center	Saint Paul55130	NCT06976216	Map
MS	Precise Research Centers	Flowood39232	NCT05980949	Map
MS	Precise Research Centers	Flowood39232	NCT06585787	Map
MS	Precise Research Centers	Flowood39232	NCT06929273	Map
MS	Precise Research Centers	Flowood39232	NCT06951711	Map
MS	Private Practice - Dr. Ronald Louis Schwartz	Hattiesburg39401	NCT06976203	Map
MO	Arch Clinical Trials	St Louis63141	NCT06929273	Map
MO	Arch Clinical Trials	St Louis63141	NCT06951711	Map
NV	Redbird Research	Las Vegas89119	NCT06937229	Map
NJ	Hassman Research Institute Marlton Site	Marlton08053	NCT06929273	Map
NJ	Hassman Research Institute Marlton Site	Marlton08053	NCT06951711	Map
NJ	Hassman Research Institute Marlton Site	Marlton08053	NCT07061288	Map
NJ	The Cognitive and Research Center of New Jersey	Springfield07081	NCT06976203	Map
NJ	Advanced Memory Research Institute - CenExel - PPDS	Toms River08755	NCT06585787	Map
NJ	Advanced Memory Research Institute of New Jersey	Toms River08755	NCT06976216	Map
NJ	Advanced Clinical Institute	West Long Branch07764	NCT06976203	Map
NY	Neurological Associates Albany	Albany12208	NCT06976203	Map
NY	Dent Neurosciences Research Center, Inc	Amherst14226	NCT06976203	Map
NY	University at Buffalo - UBMD Neurology	Buffalo14203	NCT06976203	Map
NY	Mid Hudson Medical Research PLLC	New Windsor12553-7754	NCT06585787	Map
NY	New York State Psychiatric Institute	New York10032	NCT07423546	Map
NY	NYU Langone Health	New York10016	NCT06976216	Map
NY	Richmond Behavioral Associates	Staten Island10314	NCT06929273	Map
NY	Richmond Behavioral Associates	Staten Island10314	NCT06951698	Map
NY	SUNY Upstate Medical University	Syracuse13210	NCT06976216	Map
NY	Five Towns Neurology PC -Woodmere - 923 Broadway	Woodmere11598-1739	NCT05980949	Map
NY	Five Towns Neurology, PC	Woodmere11598-1739	NCT05511363	Map
NY	Five Towns Neurology, PC	Woodmere11598-1739	NCT06585787	Map
NC	Triad Clinical Trials - 515 College Rd	Greensboro27410-3311	NCT06585787	Map
NC	AMC Research, LLC	Matthews28105	NCT06976216	Map
NC	AMC Research, LLC - Flourish - PPDS	Matthews28105-8336	NCT05980949	Map
NC	AMC Research, LLC - Flourish - PPDS	Matthews28105-8336	NCT06585787	Map
NC	West Clinical Research	Morehead City28557	NCT06585787	Map
NC	West Clinical Research	Morehead City28557	NCT06937229	Map
NC	PPD Virtual - PPD - US	Wilmington28401-3331	NCT07379827	Map
OH	University of Cincinnati Cancer Institute	Cincinnati45219	NCT07424404	Map
OH	University of Cincinnati Dept of Psychiatry and Behavioral Neuroscience	Cincinnati45219	NCT07288567	Map
OH	University of Cincinnati Medical Center	Cincinnati45219	NCT06929273	Map
OH	University of Cincinnati Medical Center	Cincinnati45219	NCT06951711	Map
OH	Ohio State University	Columbus43221	NCT06585787	Map
OH	Ohio State University	Columbus43221	NCT06976216	Map
OH	NDx Clinical Research Inc.	Dayton45459	NCT06976216	Map
OH	Insight Clinical Trials LLC - Independence	Independence44131	NCT06585787	Map
OH	Insight Clinical Trials LLC - Independence	Independence44131	NCT06947941	Map
OH	Neuro-Behavioral Clinical Research	North Canton44720	NCT06929273	Map
OH	Neuro-Behavioral Clinical Research	North Canton44720	NCT06951711	Map
OH	Neuro-Behavioral Clinical Research	North Canton44720	NCT06951698	Map
OK	The Rivus Wellness & Research Institute	Oklahoma City73112	NCT06585787	Map
OK	The Rivus Wellness & Research Institute	Oklahoma City73112-8729	NCT07379827	Map
OR	Summit Headlands	Portland97210	NCT06976216	Map
PA	Perelman School of Medicine at the University of Pennsylvania	Philadelphia19104-4238	NCT07379827	Map
PA	Keystone Clinical Studies	Plymouth Meeting19462	NCT06976203	Map
RI	Rhode Island Mood & Memory Research Institute	East Providence02914	NCT06976216	Map
RI	Alzheimer's Disease and Memory Disorders Center at Rhode Island Hospital	Providence02903	NCT06585787	Map
TN	Neurology Clinic, P.C.	Cordova38018	NCT06976216	Map
TN	Psychiatric Consultants, Pc	Franklin37607	NCT07379827	Map
TN	Vanderbilt Psychiatric Hospital	Nashville37212-3133	NCT06585787	Map
TX	Community Clinical Research	Austin78754	NCT06929273	Map
TX	Community Clinical Research	Austin78754	NCT07061288	Map
TX	Gadolin Research	Beaumont77702	NCT06976216	Map
TX	Epic Medical Research, LLC - Carrolton	Carrollton75006	NCT06937229	Map
TX	Horizon Clinical Research: Gill Neuroscience	Cypress77429-6070	NCT05980949	Map
TX	Local Institution - 1106	Cypress77429-6070	NCT06126224	Map
TX	Epic Medical Research LLC - DeSoto - HyperCore - PPDS	DeSoto75115-2043	NCT06585787	Map
TX	InSite Clinical Research	DeSoto75115	NCT06929273	Map
TX	InSite Clinical Research	DeSoto75115	NCT06951711	Map
TX	Advanced Neuro Research Center - El Paso	El Paso79912-1743	NCT06585787	Map
TX	VAST Clinical Research	Garland75043	NCT07288567	Map
TX	Clinical Trial Network - 7080 Southwest Fwy	Houston77074-2085	NCT05511363	Map
TX	Clinical Trial Network - 7080 Southwest Fwy	Houston77074-2085	NCT05980949	Map
TX	Elevate Clinical Research-Houston	Houston77058	NCT06929273	Map
TX	Pioneer Research Solutions, Inc.	Houston77099	NCT07379827	Map
TX	Prime Clinical Research - Mansfield	Mansfield76063	NCT06929273	Map
TX	Pillar Clinical Research - Richardson	Richardson75080	NCT06929273	Map
TX	Pillar Clinical Research - Richardson	Richardson75080	NCT06951711	Map
TX	Pillar Clinical Research - Richardson	Richardson75080	NCT06951698	Map
TX	Perceptive Pharma Research	Richmond77407-3498	NCT07379827	Map
TX	Central Texas Neurology Consultants, PA	Round Rock78681	NCT06976203	Map
TX	Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases	San Antonio78229-3901	NCT06585787	Map
UT	Pantheon Clinical Research, LLC	Bountiful84010	NCT06937229	Map
VA	Conquest Research, LLC - Virginia - Vienna	Vienna22182	NCT06585787	Map
WA	Northwest Clinical Research Center	Bellevue98007-4879	NCT06585787	Map
WA	Rainier Clinical Research Center	Renton98057	NCT06976203	Map

KarXT clinical trials at a glance: phase × recruitment status

Phase	recruiting	active not recruiting	completed	not yet recruiting	Total
Early P1				1	1
P1	2		2		4
P1/P2	1				1
P3	14		1	2	17
N/A	1	1			2

Recruiting KarXT clinical trials (21)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT ID	Title	Phase	Indication	Enrollment	Started
NCT07228338	Cholinergic Enhancement of Theta	Early P1	Epilepsy	50	Oct 2026
NCT07424404	A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively	P3	Schizophrenia	400	Apr 2026
NCT07288567	EMERGENT TEENA Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)	P3	Schizophrenia	166	Jan 2026
NCT06882785	A Study to Evaluate the Efficacy and Safety of KarXT in Acutely Psychotic Japanese Adult Participants With Schizophrenia	P3	Schizophrenia	250	Jun 2025
NCT07285798	A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism Spectrum Disorder	P3	Irritability Associated With Autism Spectrum Disorder	176	Sep 2026
NCT06937229	ADAGIO-3A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)	P3	Alzheimer Disease	650	Dec 2025
NCT07284745	A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism	P3	Irritability Associated With Autism Spectrum Disorder	176	Sep 2026
NCT06976203	MINDSET 2A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)	P3	Alzheimer's Disease	586	Jul 2025
NCT06976216	MINDSET 1A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease	P3	Alzheimer's Disease	586	Jul 2025
NCT07379827	Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)	—	Schizophrenia	1,500	Feb 2026
NCT06929273	BALSAM-3A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)	P3	Bipolar Disorder Type I With Mania	450	Jul 2025
NCT06947941	ADEPT-5A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)	P3	Alzheimer Disease	325	Mar 2026
NCT07423546	A PET/MRI Study of Cobenfy on Dopamine Transmission in Schizophrenia	P1/P2	SCHIZOPHRENIA 1 (Disorder)	12	Jul 2026
NCT07061288	A Study to Evaluate the Safety, Tolerability, and PK of an Injectable Form of KarXT	P1	Schizophrenia	116	Sep 2025
NCT05980949	ADEPT-3Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)	P3	Psychosis Associated With Alzheimer's Disease	1,000	Jul 2023
NCT06585787	ADEPT-4A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)	P3	Alzheimer Disease	406	Sep 2024
NCT06126224	ADEPT-2A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)	P3	Psychosis Associated With Alzheimer's Disease	500	Aug 2023
NCT06951711	BALSAM-2A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)	P3	Bipolar Disorder Type I With Mania or Mania With Mixed Features	274	Jun 2025
NCT06951698	BALSAM-1A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder	P3	Bipolar-I Disorder With Mania or Mania With Mixed Features	274	Jun 2025
NCT05511363	ADEPT-1A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)	P3	Psychosis Associated With Alzheimer's Disease	410	Aug 2022
NCT07118215	A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin	P1	Healthy Volunteers	60	Sep 2025

KarXT clinical trials by indication

Schizophrenia (7)

NCT	Acronym	Phase	Status	Title
NCT07424404	—	P3	recruiting	A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively
NCT07288567	EMERGENT TEEN	P3	recruiting	A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)
NCT06882785	—	P3	recruiting	A Study to Evaluate the Efficacy and Safety of KarXT in Acutely Psychotic Japanese Adult Participants With Schizophrenia
NCT07379827	—	N/A	recruiting	Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)
NCT07061288	—	P1	recruiting	A Study to Evaluate the Safety, Tolerability, and PK of an Injectable Form of KarXT
NCT07571148	—	N/A	active not recruiting	Real-world Patient Characteristics, Treatment Patterns, and Healthcare Utilization Among KarXT Users
NCT06572449	—	P3	completed	Study to Assess Safety and Effectiveness of Slowly Increasing Dose and Food Effect of KarXT in Participants With Schizophrenia

Alzheimer Disease (3)

NCT	Acronym	Phase	Status	Title
NCT06937229	ADAGIO-3	P3	recruiting	A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
NCT06947941	ADEPT-5	P3	recruiting	A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)
NCT06585787	ADEPT-4	P3	recruiting	A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

Psychosis Associated With Alzheimer's Disease (3)

NCT	Acronym	Phase	Status	Title
NCT05980949	ADEPT-3	P3	recruiting	Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
NCT06126224	ADEPT-2	P3	recruiting	A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)
NCT05511363	ADEPT-1	P3	recruiting	A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)

Irritability Associated With Autism Spectrum Disorder (2)

NCT	Acronym	Phase	Status	Title
NCT07285798	—	P3	not yet recruiting	A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism Spectrum Disorder
NCT07284745	—	P3	not yet recruiting	A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism

Healthy Volunteers (2)

NCT	Acronym	Phase	Status	Title
NCT07118215	—	P1	recruiting	A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin
NCT06605950	PK	P1	completed	A Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of Xanomeline With Trospium Chloride Versus KarXT in Healthy Adult and Elderly Participants of Japanese Ethnicity and to Assess the Effect of Omeprazole on the PK of Xanomeline With Trospium Chloride in Healthy Adult Participants

Alzheimer's Disease (2)

NCT	Acronym	Phase	Status	Title
NCT06976203	MINDSET 2	P3	recruiting	A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
NCT06976216	MINDSET 1	P3	recruiting	A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

Epilepsy (1)

NCT	Acronym	Phase	Status	Title
NCT07228338	—	Early P1	not yet recruiting	Cholinergic Enhancement of Theta

SCHIZOPHRENIA 1 (Disorder) (1)

NCT	Acronym	Phase	Status	Title
NCT07423546	—	P1/P2	recruiting	A PET/MRI Study of Cobenfy on Dopamine Transmission in Schizophrenia

Bipolar Disorder Type I With Mania (1)

NCT	Acronym	Phase	Status	Title
NCT06929273	BALSAM-3	P3	recruiting	A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

Bipolar Disorder Type I With Mania or Mania With Mixed Features (1)

NCT	Acronym	Phase	Status	Title
NCT06951711	BALSAM-2	P3	recruiting	A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)

Bipolar-I Disorder With Mania or Mania With Mixed Features (1)

NCT	Acronym	Phase	Status	Title
NCT06951698	BALSAM-1	P3	recruiting	A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder

Psychiatric Disorders (1)

NCT	Acronym	Phase	Status	Title
NCT06853171	—	P1	completed	Safety, Tolerability, and Pharmacokinetics of KarXT and Dual-burst Release of Xanomeline With Immediate-release Trospium Chloride in Adolescents With Psychiatric Disorders

KarXT pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

Acronym	NCT	Phase	Status	Indication	Enrollment	PubMed
EMERGENT TEEN	NCT07288567	P3	recruiting	Schizophrenia	166	—
ADAGIO-3	NCT06937229	P3	recruiting	Alzheimer Disease	650	—
MINDSET 2	NCT06976203	P3	recruiting	Alzheimer's Disease	586	—
MINDSET 1	NCT06976216	P3	recruiting	Alzheimer's Disease	586	—
BALSAM-3	NCT06929273	P3	recruiting	Bipolar Disorder Type I With Mania	450	—
ADEPT-5	NCT06947941	P3	recruiting	Alzheimer Disease	325	—
ADEPT-3	NCT05980949	P3	recruiting	Psychosis Associated With Alzheimer's Disease	1,000	—
ADEPT-4	NCT06585787	P3	recruiting	Alzheimer Disease	406	—
ADEPT-2	NCT06126224	P3	recruiting	Psychosis Associated With Alzheimer's Disease	500	—
BALSAM-2	NCT06951711	P3	recruiting	Bipolar Disorder Type I With Mania or Mania With Mixed Features	274	—
BALSAM-1	NCT06951698	P3	recruiting	Bipolar-I Disorder With Mania or Mania With Mixed Features	274	—
ADEPT-1	NCT05511363	P3	recruiting	Psychosis Associated With Alzheimer's Disease	410	—

All KarXT trials (25)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT ID	Acronym	Title	Phase	Status	Enrollment	Sponsor	Started
NCT07228338		Cholinergic Enhancement of Theta	Early P1	not yet recruiting	50	University of Texas Southwestern Medical Center	Oct 2026
NCT07424404		A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively	P3	recruiting	400	Karuna Therapeutics, Inc., a Bristol Myers Squibb company	Apr 2026
NCT07288567	EMERGENT TEEN	A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)	P3	recruiting	166	Bristol-Myers Squibb	Jan 2026
NCT06882785		A Study to Evaluate the Efficacy and Safety of KarXT in Acutely Psychotic Japanese Adult Participants With Schizophrenia	P3	recruiting	250	Bristol-Myers Squibb	Jun 2025
NCT07285798		A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism Spectrum Disorder	P3	not yet recruiting	176	Bristol-Myers Squibb	Sep 2026
NCT06937229	ADAGIO-3	A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)	P3	recruiting	650	Bristol-Myers Squibb	Dec 2025
NCT07284745		A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism	P3	not yet recruiting	176	Bristol-Myers Squibb	Sep 2026
NCT06976203	MINDSET 2	A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)	P3	recruiting	586	Bristol-Myers Squibb	Jul 2025
NCT06976216	MINDSET 1	A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease	P3	recruiting	586	Bristol-Myers Squibb	Jul 2025
NCT07379827		Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)	—	recruiting	1,500	Bristol-Myers Squibb	Feb 2026
NCT06929273	BALSAM-3	A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)	P3	recruiting	450	Bristol-Myers Squibb	Jul 2025
NCT06947941	ADEPT-5	A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)	P3	recruiting	325	Bristol-Myers Squibb	Mar 2026
NCT07423546		A PET/MRI Study of Cobenfy on Dopamine Transmission in Schizophrenia	P1/P2	recruiting	12	New York State Psychiatric Institute	Jul 2026
NCT07061288		A Study to Evaluate the Safety, Tolerability, and PK of an Injectable Form of KarXT	P1	recruiting	116	Bristol-Myers Squibb	Sep 2025
NCT05980949	ADEPT-3	Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)	P3	recruiting	1,000	Karuna Therapeutics, Inc., a Bristol Myers Squibb company	Jul 2023
NCT06585787	ADEPT-4	A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)	P3	recruiting	406	Karuna Therapeutics, Inc., a Bristol Myers Squibb company	Sep 2024
NCT06126224	ADEPT-2	A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)	P3	recruiting	500	Karuna Therapeutics, Inc., a Bristol Myers Squibb company	Aug 2023
NCT06951711	BALSAM-2	A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)	P3	recruiting	274	Bristol-Myers Squibb	Jun 2025
NCT06951698	BALSAM-1	A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder	P3	recruiting	274	Bristol-Myers Squibb	Jun 2025
NCT05511363	ADEPT-1	A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)	P3	recruiting	410	Karuna Therapeutics, Inc., a Bristol Myers Squibb company	Aug 2022
NCT07571148		Real-world Patient Characteristics, Treatment Patterns, and Healthcare Utilization Among KarXT Users	—	active not recruiting	6,876	Bristol-Myers Squibb	Jan 2026
NCT07118215		A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin	P1	recruiting	60	Karuna Therapeutics, Inc., a Bristol Myers Squibb company	Sep 2025
NCT06853171		Safety, Tolerability, and Pharmacokinetics of KarXT and Dual-burst Release of Xanomeline With Immediate-release Trospium Chloride in Adolescents With Psychiatric Disorders	P1	completed	24	Bristol-Myers Squibb	Apr 2025
NCT06605950	PK	A Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of Xanomeline With Trospium Chloride Versus KarXT in Healthy Adult and Elderly Participants of Japanese Ethnicity and to Assess the Effect of Omeprazole on the PK of Xanomeline With Trospium Chloride in Healthy Adult Participants	P1	completed	78	Karuna Therapeutics, Inc., a Bristol Myers Squibb company	Oct 2024
NCT06572449		Study to Assess Safety and Effectiveness of Slowly Increasing Dose and Food Effect of KarXT in Participants With Schizophrenia	P3	completed	173	Karuna Therapeutics, Inc., a Bristol Myers Squibb company	Oct 2024

KarXT clinical trials: frequently asked questions

How many KarXT clinical trials are there?: 25 KarXT clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 18 are actively recruiting participants. 3 are marked completed.
Are KarXT clinical trials recruiting in 2026?: Yes — 18 KarXT trials are actively recruiting in 2026, with 287 U.S. sites across 31 states. See the recruiting trials and the per-state site list further down this page.
What conditions is KarXT being studied for?: KarXT is being studied for Schizophrenia, Psychosis Associated With Alzheimer's Disease, Alzheimer Disease, Irritability Associated With Autism Spectrum Disorder, Alzheimer's Disease and 15 more. The trials are grouped by indication on this page.
What phase is KarXT in?: KarXT clinical trials span 17 Phase 3, 4 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors KarXT clinical trials?: The lead sponsor across the most KarXT trials is Bristol-Myers Squibb, with 3 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming KarXTas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

Last refreshed July 17, 2026.

Related pages on Hipa.ai:

KarXT overview