Primary completion· ClinicalTrials.gov
Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health
Tirzepatide History and Updates
250 events · 2016 – present
Synced daily from openFDA and ClinicalTrials.gov. Last sync: .
24
FDA Approvals
0
Label Revisions
696
Trial Milestones
10
Pivotal Publications
Source: openFDA, ClinicalTrials.gov via AACT, PubMed · Hipa.ai, 2026-07-31Download chart as PNG
This page tracks every FDA action, clinical trial milestone, and major publication for Tirzepatide since 2016, drawn from openFDA, ClinicalTrials.gov, and PubMed.
All published updates (21)
2026
- Label revisionMounjaro (Tirzepatide) Label Adds Boxed Warning for Thyroid C-Cell Tumors· Jul 29, 2026
- Primary completionTirzepatide Phase 3 Trial for Adolescent Obesity Reaches Primary Completion· Jun 2, 2026
- Primary completionTirzepatide Phase 3 Study for Weight Reduction Maintenance Completes Primary· Jan 20, 2026
2025
- FDA approval (supplemental)Mounjaro (Tirzepatide) Receives FDA Supplemental Efficacy Approval· Dec 19, 2025
- Results postedTirzepatide Monotherapy Shows Significant HbA1c Reduction in Type 2 Diabetes· Oct 21, 2025
- Results postedTirzepatide Significantly Lowers HbA1c in Pediatric Type 2 Diabetes· Sep 26, 2025
- Results postedTirzepatide Phase 1 Pediatric Obesity Trial Shows High TEAE Incidence· Aug 26, 2025
- Results postedTirzepatide SUMMIT Trial for HFpEF and Obesity Improves KCCQ Scores, Reduces…· Aug 20, 2025
- Results postedTirzepatide Phase 3 Trial in Chinese Type 2 Diabetes Lowers HbA1c· Aug 8, 2025
- Results postedTirzepatide Reduces Obstructive Sleep Apnea Severity in Phase 3 Trial· Apr 30, 2025
- Results postedTirzepatide Trial Results Posted for Healthy Lactating Females· Apr 27, 2025
- Pivotal publicationTirzepatide Trial for HFpEF and Obesity Results Published· Jan 1, 2025
- Pivotal publicationTirzepatide vs. Semaglutide Obesity Treatment Data Published in NEJM· Jan 1, 2025
- Pivotal publicationTirzepatide Phase 3 SURPASS-PEDS Results Published for Pediatric Type 2 Diabetes· Jan 1, 2025
- Pivotal publicationTirzepatide Publication Details Obesity Treatment and Diabetes Prevention· Jan 1, 2025
- Pivotal publicationTirzepatide Cardiovascular Outcomes vs. Dulaglutide in Type 2 Diabetes· Jan 1, 2025
2024
- Pivotal publicationTirzepatide Shows Weight Reduction in Chinese Adults with Obesity in…· Jan 1, 2024
- Pivotal publicationTirzepatide SURMOUNT-4 Trial Results Published for Weight Maintenance· Jan 1, 2024
- Pivotal publicationTirzepatide Results Published for Obstructive Sleep Apnea and Obesity· Jan 1, 2024
2023
- Pivotal publicationTirzepatide vs Insulin Lispro in Type 2 Diabetes: SURPASS-6 Trial Findings· Jan 1, 2023
- Pivotal publicationTirzepatide SURMOUNT-2 Results for Obesity in Type 2 Diabetes Published· Jan 1, 2023
Upcoming & expected milestones
Trial started· ClinicalTrials.gov
Safety and Efficacy of NA-931 and Tirzepatide in Adults Who Are Overweight or Obese
Trial started· ClinicalTrials.gov
Tirzepatide for Treatment of CCCA
Primary completion· ClinicalTrials.gov
A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepati
Trial started· ClinicalTrials.gov
GLP-1 Agonists for Lung Function Improvement and Muscle Restoration in COPD
Primary completion· ClinicalTrials.gov
Effect of Tirzepatide on Markers of MASLD in Patients With Obesity
Trial started· ClinicalTrials.gov
Tirzepatide in Idiopathic Intracranial Hypertension Trial
Primary completion· ClinicalTrials.gov
Tirzepatide for Alcohol Use Disorder
Trial started· ClinicalTrials.gov
The Effect of Exercise and Tirzepatide on Weight and Health Outcomes (EXER-MED)
Trial started· ClinicalTrials.gov
Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer
Trial started· ClinicalTrials.gov
Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients
Primary completion· ClinicalTrials.gov
GLP-1s to Enhance Lasting Optimal Weight
Primary completion· ClinicalTrials.gov
Tolerance and Pharmacokinetic/Pharmacokinetic Study of IBI362 15mg in Patients With Moderate to Severe Obesity
Primary completion· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
Primary completion· ClinicalTrials.gov
Effect of Semaglutide and Tirzepatide Combined With Exercise in Obesity
Primary completion· ClinicalTrials.gov
Safety and Effectiveness of Tirzepatide in Patients With Obesity at Hospital de Clínicas, Paraguay
Trial started· ClinicalTrials.gov
Trial of Tirzepatide for the Treatment of Cannabis Use Disorder
Primary completion· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight
Primary completion· ClinicalTrials.gov
A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
Primary completion· ClinicalTrials.gov
A Study to Evaluate the Effect of Fasting Duration and Tirzepatide Withholding on the Amount of Food and Fluid in the Stomach in Participant
Primary completion· ClinicalTrials.gov
A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity
Primary completion· ClinicalTrials.gov
GLP-1R Actions on Muscle and the Skeleton
Primary completion· ClinicalTrials.gov
A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity
Primary completion· ClinicalTrials.gov
The Long COVID Treatment Trial
Primary completion· ClinicalTrials.gov
Tirzepatide and Muscle Outcomes in Obesity
Primary completion· ClinicalTrials.gov
Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women
Primary completion· ClinicalTrials.gov
2024 Tirzepatide-Bariatric Surgery
Primary completion· ClinicalTrials.gov
TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation
Primary completion· ClinicalTrials.gov
Pre-Surgical Tirzepatide-Assisted Weight Loss in Overweight and Obese Men With Intermediate Risk Prostate Cancer: A Pilot Feasibility Study
Trial started· ClinicalTrials.gov
Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity
Primary completion· ClinicalTrials.gov
The Effect of Exercise and Tirzepatide on Weight and Health Outcomes (EXER-MED)
Primary completion· ClinicalTrials.gov
GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial
Primary completion· ClinicalTrials.gov
Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.
Primary completion· ClinicalTrials.gov
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-rela
Primary completion· ClinicalTrials.gov
GLP-1R Actions on Muscle and the Skeleton
Primary completion· ClinicalTrials.gov
Efficacy and Safety of HDM1005 Compared to Tirzepatide in Obese Adults Without Diabetes
Primary completion· ClinicalTrials.gov
Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbi
Primary completion· ClinicalTrials.gov
Phase 1/2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effect on Body Weight of RN3161 as Monotherapy
Primary completion· ClinicalTrials.gov
Tirzepatide in Idiopathic Intracranial Hypertension Trial
Primary completion· ClinicalTrials.gov
Weight-loss Drug for Fertility-Sparing Treatment of Atypical Hyperplasia and Low-grade Cancer of the Endometrium
Primary completion· ClinicalTrials.gov
Study of Tirzepatide for Recovery and Alcohol Use Management
Primary completion· ClinicalTrials.gov
Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) and Diet in Inflammatory Bowel Disease (IBD) Patients
Primary completion· ClinicalTrials.gov
The Effects of Tirzepatide in People With Overweight/Obesity and Coronary Artery Disease
Primary completion· ClinicalTrials.gov
Pathways, Risk Factors, and mOleculeS to Prevent Early-onset Colorectal Tumors
Primary completion· ClinicalTrials.gov
Randomized Control Trial of Sleeve Gastrectomy with Tirzepatide in Maximizing Weight Loss
Primary completion· ClinicalTrials.gov
Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults
Primary completion· ClinicalTrials.gov
Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity
Primary completion· ClinicalTrials.gov
A Study to Evaluate ALN-2232 in Participants With Obesity
Primary completion· ClinicalTrials.gov
DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies
Primary completion· ClinicalTrials.gov
Tirzepatide Combined With Cognitive-Behavioural Therapy (CBT) for Adults With Alcohol Use Disorder (AUD) and Overweight/Obesity (OOB)
Past events
2026
Trial started· ClinicalTrials.gov
Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial
Trial registered· ClinicalTrials.gov
GLP-1 Agonists for Lung Function Improvement and Muscle Restoration in COPD
Trial started· ClinicalTrials.gov
Clinical Study of Local and Systemic Biological Impact of GLP1/GIP-Receptor Agonists in Patients With Breast Cancer: The CLARA Trial
Trial started· ClinicalTrials.gov
Tirzepatide on Atrial Fibrillation Recurrence After Catheter Ablation in Patients With Obesity and HFpEF
Trial started· ClinicalTrials.gov
An Open-Label Tirzepatide Trial for Comorbid Obesity and Stimulant Use Disorder
Trial started· ClinicalTrials.gov
Tirzepatide in the Treatment of Cannabis Use Disorder
Trial registered· ClinicalTrials.gov
Evaluation of the Efficacy and Safety of Tirzepatide, a Dual GLP-1/GIP Agonist, on Functional Capacity in Reduced Ejection Fraction Heart Fa
Trial started· ClinicalTrials.gov
Tirzepatide Following Adrenalectomy in Mild Autonomous Cortisol Secretion
Primary completion· ClinicalTrials.gov
Tirzepatide (Spartina) in Obese Kidney Transplant Recipients
Trial started· ClinicalTrials.gov
Effect of Tirzepatide on Diabetic Peripheral Sensorimotor Neuropathy
Primary completion· ClinicalTrials.gov
Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIV
Primary completion· ClinicalTrials.gov
Tirzepatide in MetALD
Label revision· FDA
WARNING: RISK OF THYROID C-CELL TUMORS In both male and female rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether MOUNJARO causes thyroid C-
Label revision· FDA
WARNING: RISK OF THYROID C-CELL TUMORS In both male and female rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether MOUNJARO causes thyroid C-
Label revision· FDA
WARNING: RISK OF THYROID C-CELL TUMORS In both male and female rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether MOUNJARO causes thyroid C-
Label revision· FDA
WARNING: RISK OF THYROID C-CELL TUMORS In both male and female rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether MOUNJARO causes thyroid C-
Trial registered· ClinicalTrials.gov
Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial
Trial registered· ClinicalTrials.gov
Tirzepatide for Treatment of CCCA
Label revision· FDA
WARNING: RISK OF THYROID C-CELL TUMORS In both male and female rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether MOUNJARO causes thyroid C-
Label revision· FDA
WARNING: RISK OF THYROID C-CELL TUMORS In both male and female rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether MOUNJARO causes thyroid C-
Trial registered· ClinicalTrials.gov
Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients
Trial started· ClinicalTrials.gov
AI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 Diabetes
Trial registered· ClinicalTrials.gov
Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIV
Trial registered· ClinicalTrials.gov
Effect of Tirzepatide on Diabetic Peripheral Sensorimotor Neuropathy
Trial registered· ClinicalTrials.gov
Non-Invasive Hepatic and Metabolic Index Changes After Incretin Therapy in Overweight/Obesity
Trial registered· ClinicalTrials.gov
AI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 Diabetes
Trial registered· ClinicalTrials.gov
An Open-Label Tirzepatide Trial for Comorbid Obesity and Stimulant Use Disorder
Results posted· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
Trial started· ClinicalTrials.gov
A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometr
Primary completion· ClinicalTrials.gov
A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obe
Trial started· ClinicalTrials.gov
Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes
Primary completion· ClinicalTrials.gov
Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity
Trial started· ClinicalTrials.gov
Tirzepatide for the Treatment of Cannabis Use Disorder
Trial started· ClinicalTrials.gov
Incretin Therapies in Obesity-related HFpEF
Trial registered· ClinicalTrials.gov
Clinical Study of Local and Systemic Biological Impact of GLP1/GIP-Receptor Agonists in Patients With Breast Cancer: The CLARA Trial
Primary completion· ClinicalTrials.gov
A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obe
Primary completion· ClinicalTrials.gov
Efficacy and Safety of Tirzepatide for Weight Management
Primary completion· ClinicalTrials.gov
Tirzepatide in PWS, HO and GNSO
Primary completion· ClinicalTrials.gov
GIP/GLP-1RA as Adjunctive to Automated Insulin Delivery in Adults With Type 1 Diabetes
Primary completion· ClinicalTrials.gov
A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
Trial registered· ClinicalTrials.gov
Tirzepatide in the Treatment of Cannabis Use Disorder: A Proof-of-Concept Study
Primary completion· ClinicalTrials.gov
INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD)
Trial registered· ClinicalTrials.gov
Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.
Trial started· ClinicalTrials.gov
Tirzepatide to Reduce rEcurrence And Burden After Ablation of Atrial Fibrillation
Trial registered· ClinicalTrials.gov
Tirzepatide on Atrial Fibrillation Recurrence After Catheter Ablation in Patients With Obesity and HFpEF
Primary completion· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
Primary completion· ClinicalTrials.gov
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated
Primary completion· ClinicalTrials.gov
Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIV
Trial registered· ClinicalTrials.gov
Tirzepatide vs Semaglutide in Individuals at Cardiovascular Risk But Without Diabetes.
Primary completion· ClinicalTrials.gov
Tirzepatide vs Semaglutide in Individuals at Cardiovascular Risk But Without Diabetes.
Trial started· ClinicalTrials.gov
Tirzepatide in the Treatment of Endometrial Cancer
Primary completion· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
Trial started· ClinicalTrials.gov
CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Re
Trial started· ClinicalTrials.gov
Multi-Site Trial of Tirzepatide for Smoking Cessation
Primary completion· ClinicalTrials.gov
Study of Tirzepatide for Recovery and Alcohol Use Management
Trial started· ClinicalTrials.gov
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Primary completion· ClinicalTrials.gov
INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD)
Trial registered· ClinicalTrials.gov
Tirzepatide in the Treatment of Endometrial Cancer
Trial registered· ClinicalTrials.gov
Multi-Site Trial of Tirzepatide for Smoking Cessation
Trial started· ClinicalTrials.gov
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Trial started· ClinicalTrials.gov
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Trial started· ClinicalTrials.gov
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Trial started· ClinicalTrials.gov
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Trial started· ClinicalTrials.gov
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Trial registered· ClinicalTrials.gov
GLP-1 Medication & Behavioral Health Programs on Weight & Metabolic Outcomes: FLOURISH and THRIVE Prospective Cohort Study
Trial started· ClinicalTrials.gov
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Trial started· ClinicalTrials.gov
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Trial started· ClinicalTrials.gov
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Trial registered· ClinicalTrials.gov
Tirzepatide Following Adrenalectomy in Mild Autonomous Cortisol Secretion
Trial registered· ClinicalTrials.gov
CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Re
Trial started· ClinicalTrials.gov
Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health
Trial started· ClinicalTrials.gov
Tirzepatide to Reduce rEcurrence And Burden After Ablation of Atrial Fibrillation
Trial started· ClinicalTrials.gov
The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity
Primary completion· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes During Ramadan
Trial started· ClinicalTrials.gov
AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN)
Primary completion· ClinicalTrials.gov
Effectiveness and Safety of Tirzepatide Among Participants With Obesity With or Without Type 2 Diabetes Mellitus (T2DM)
Primary completion· ClinicalTrials.gov
A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Ob
Trial started· ClinicalTrials.gov
Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer
Trial registered· ClinicalTrials.gov
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)
Trial registered· ClinicalTrials.gov
AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN)
Trial registered· ClinicalTrials.gov
Incretin Therapies in Obesity-related HFpEF
Trial started· ClinicalTrials.gov
Tirzepatide in Obesity-Driven Endometrial Cancer
Trial started· ClinicalTrials.gov
Resistance Exercise and Incretin Mimetic for Cardiometabolic Health in Survivors of ALL With Obesity
Trial started· ClinicalTrials.gov
A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLD
Primary completion· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes During Ramadan
Trial registered· ClinicalTrials.gov
A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLD
Trial registered· ClinicalTrials.gov
Efficacy and Safety of HDM1005 Compared to Tirzepatide in Obese Adults Without Diabetes
Trial started· ClinicalTrials.gov
Tirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors
Trial started· ClinicalTrials.gov
Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity
Primary completion· ClinicalTrials.gov
Efficacy and Safety of Tirzepatide (Spartina) in Chronic Kidney Failure
Trial started· ClinicalTrials.gov
Tirzepatide in MetALD
Trial started· ClinicalTrials.gov
Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults
Trial started· ClinicalTrials.gov
DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies
Primary completion· ClinicalTrials.gov
INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD)
Trial started· ClinicalTrials.gov
Safety and Effectiveness of Tirzepatide in Patients With Obesity at Hospital de Clínicas, Paraguay
Trial registered· ClinicalTrials.gov
Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity
Trial started· ClinicalTrials.gov
Efficacy and Safety of HDM1005 Compared to Tirzepatide in Obese Adults Without Diabetes
Primary completion· ClinicalTrials.gov
Tirzepatide for Obesity and Meth Use Disorder
Primary completion· ClinicalTrials.gov
Non-Invasive Hepatic and Metabolic Index Changes After Incretin Therapy in Overweight/Obesity
Trial registered· ClinicalTrials.gov
Safety and Effectiveness of Tirzepatide in Patients With Obesity at Hospital de Clínicas, Paraguay
Primary completion· ClinicalTrials.gov
Effects of Tirzepatide on Blood, Imaging and Breast Tissue Biomarkers
Trial registered· ClinicalTrials.gov
Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbi
Trial registered· ClinicalTrials.gov
DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies
Trial registered· ClinicalTrials.gov
Trial of Tirzepatide for the Treatment of Cannabis Use Disorder
Trial registered· ClinicalTrials.gov
A Study to Evaluate ALN-2232 in Participants With Obesity
Trial started· ClinicalTrials.gov
Combination of Biologic and Anti-obesity Therapies in Psoriatic Arthritis
Primary completion· ClinicalTrials.gov
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated
Trial started· ClinicalTrials.gov
A Study to Evaluate ALN-2232 in Participants With Obesity
Trial registered· ClinicalTrials.gov
Combination of Biologic and Anti-obesity Therapies in Psoriatic Arthritis
Primary completion· ClinicalTrials.gov
Effects of Tirzepatide on Blood, Imaging and Breast Tissue Biomarkers
Primary completion· ClinicalTrials.gov
Phase 1/1b Study of TLC-6740 in Healthy Subjects and Subjects With Obesity, With or Without Diabetes
Trial started· ClinicalTrials.gov
Tirzepatide in Idiopathic Intracranial Hypertension Trial
Trial started· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or Obesity
Trial started· ClinicalTrials.gov
Tirzepatide to Slow Biological Aging
Trial registered· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or Obesity
Primary completion· ClinicalTrials.gov
Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight Participants
FDA approval (supplemental)· FDA
Sponsor: ELI LILLY AND CO. Class: Labeling.
Trial started· ClinicalTrials.gov
Pathways, Risk Factors, and mOleculeS to Prevent Early-onset Colorectal Tumors
Trial registered· ClinicalTrials.gov
Tirzepatide (Spartina) in Obese Kidney Transplant Recipients
Trial registered· ClinicalTrials.gov
INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD)
Primary completion· ClinicalTrials.gov
Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight Participants
Trial started· ClinicalTrials.gov
Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbi
Trial registered· ClinicalTrials.gov
Tirzepatide to Reduce rEcurrence And Burden After Ablation of Atrial Fibrillation
Trial started· ClinicalTrials.gov
Efficacy and Safety of Tirzepatide (Spartina) in Chronic Kidney Failure
Trial started· ClinicalTrials.gov
Tirzepatide and Muscle Outcomes in Obesity
Trial started· ClinicalTrials.gov
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-rela
Primary completion· ClinicalTrials.gov
Anti-obesity Pharmacotherapy and Inflammation
Trial started· ClinicalTrials.gov
Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder
Trial registered· ClinicalTrials.gov
Tirzepatide and Muscle Outcomes in Obesity
Trial started· ClinicalTrials.gov
INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD)
Trial registered· ClinicalTrials.gov
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-rela
Trial started· ClinicalTrials.gov
Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostat
Primary completion· ClinicalTrials.gov
A Study of LY3298176 (Tirzepatide) For the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-R
FDA approval (supplemental)· FDA
Sponsor: ELI LILLY AND CO. Class: Labeling.
FDA approval (supplemental)· FDA
Sponsor: ELI LILLY AND CO. Class: Labeling.
Trial registered· ClinicalTrials.gov
A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometr
Primary completion· ClinicalTrials.gov
A Study of Eloralintide (LY3841136) and Eloralintide With Tirzepatide in Participants With Overweight or Obesity
Primary completion· ClinicalTrials.gov
A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Ob
Trial started· ClinicalTrials.gov
Tirzepatide Combined With Cognitive-Behavioural Therapy (CBT) for Adults With Alcohol Use Disorder (AUD) and Overweight/Obesity (OOB)
Trial started· ClinicalTrials.gov
A Study to Evaluate the Effect of Fasting Duration and Tirzepatide Withholding on the Amount of Food and Fluid in the Stomach in Participant
Primary completion· ClinicalTrials.gov
A Study of BGM0504 in Participants With Obesity
Primary completion· ClinicalTrials.gov
A Study of Investigational Tirzepatide (LY3298176) Doses in Participants With Type 2 Diabetes and Obesity
Trial registered· ClinicalTrials.gov
A Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are Overweight or Obese
Primary completion· ClinicalTrials.gov
Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight
FDA approval (supplemental)· FDA
Sponsor: ELI LILLY AND CO. Class: Manufacturing (CMC).
FDA approval (supplemental)· FDA
Sponsor: ELI LILLY AND CO. Class: Manufacturing (CMC).
Trial registered· ClinicalTrials.gov
Effect of Semaglutide and Tirzepatide Combined With Exercise in Obesity
Trial started· ClinicalTrials.gov
A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar
Trial started· ClinicalTrials.gov
Tirzepatide (Spartina) in Obese Kidney Transplant Recipients
2025
Primary completion· ClinicalTrials.gov
Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT
Trial registered· ClinicalTrials.gov
Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD
Trial started· ClinicalTrials.gov
Effect of Semaglutide and Tirzepatide Combined With Exercise in Obesity
Trial registered· ClinicalTrials.gov
Improving Cardiovascular Disease Diagnosis and Treatment in Kazakhstan Using Metabolic Correction With GLP-1 Drugs
Trial registered· ClinicalTrials.gov
A Study to Evaluate the Effect of Fasting Duration and Tirzepatide Withholding on the Amount of Food and Fluid in the Stomach in Participant
Trial registered· ClinicalTrials.gov
The Effect of Exercise and Tirzepatide on Weight and Health Outcomes (EXER-MED)
FDA approval (supplemental)· FDA
Sponsor: ELI LILLY AND CO. Class: Efficacy.
Trial registered· ClinicalTrials.gov
Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity
Trial registered· ClinicalTrials.gov
Tirzepatide Combined With Cognitive-Behavioural Therapy (CBT) for Adults With Alcohol Use Disorder (AUD) and Overweight/Obesity (OOB)
Trial registered· ClinicalTrials.gov
A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar
Primary completion· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity
Trial started· ClinicalTrials.gov
A Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are Overweight or Obese
Primary completion· ClinicalTrials.gov
A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight
Trial registered· ClinicalTrials.gov
Tirzepatide for the Treatment of Cannabis Use Disorder
Trial registered· ClinicalTrials.gov
Tirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors
Primary completion· ClinicalTrials.gov
Comparative Study of Tirzepatide Versus Dulaglutide (SURPASS CVOT) or Semaglutide on Major Cardiovascular Events in Participants With Type 2
Trial started· ClinicalTrials.gov
Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes
Primary completion· ClinicalTrials.gov
Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fract
Primary completion· ClinicalTrials.gov
Effect of Tirzepatide on Brown Adipose Tissue in Obesity
Primary completion· ClinicalTrials.gov
Effect of Tirzepatide on Brown Adipose Tissue in Obesity
Results posted· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities
Trial registered· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
Trial registered· ClinicalTrials.gov
Phase 1/2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effect on Body Weight of RN3161 as Monotherapy
Trial started· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
Primary completion· ClinicalTrials.gov
A Study of LY3841136 in Japanese Participants With Obesity or Overweight
Primary completion· ClinicalTrials.gov
Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Psoriatic Arthritis and Obesity or Overweight
Trial registered· ClinicalTrials.gov
Resistance Exercise and Incretin Mimetic for Cardiometabolic Health in Survivors of ALL With Obesity
Trial started· ClinicalTrials.gov
Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIV
Trial started· ClinicalTrials.gov
Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity
Trial started· ClinicalTrials.gov
Phase 1/2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effect on Body Weight of RN3161 as Monotherapy
Trial started· ClinicalTrials.gov
The Long COVID Treatment Trial
Trial registered· ClinicalTrials.gov
Tirzepatide to Slow Biological Aging
Primary completion· ClinicalTrials.gov
A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
Results posted· ClinicalTrials.gov
A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes (SURPASS-CN-MONO)
Trial registered· ClinicalTrials.gov
The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity
Primary completion· ClinicalTrials.gov
Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT)
Trial started· ClinicalTrials.gov
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
Trial started· ClinicalTrials.gov
GLP-1R Actions on Muscle and the Skeleton
Trial started· ClinicalTrials.gov
Tirzepatide for Alcohol Use Disorder
Trial registered· ClinicalTrials.gov
Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT)
Trial started· ClinicalTrials.gov
Effects of Long-Acting GLP-1 (Glucagon-like Peptide-1) or Dual Incretin (GLP-1 and GIP [Glucose-dependent Insulinotropic Peptide]) Modulatio
Trial registered· ClinicalTrials.gov
Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostat
Trial started· ClinicalTrials.gov
Effectiveness and Safety of Tirzepatide Among Participants With Obesity With or Without Type 2 Diabetes Mellitus (T2DM)
Primary completion· ClinicalTrials.gov
A Study of LY3841136 in Overweight and Obese Participants
Results posted· ClinicalTrials.gov
A Study to Evaluate Tirzepatide (LY3298176) in Pediatric and Adolescent Participants With Type 2 Diabetes Mellitus Inadequately Controlled W
Primary completion· ClinicalTrials.gov
A Study of Bimagrumab Alone (LY3985863) and Bimagrumab With Tirzepatide (LY900042) in Healthy Participants
FDA approval (supplemental)· FDA
Sponsor: ELI LILLY AND CO. Class: Labeling.
FDA approval (supplemental)· FDA
Sponsor: ELI LILLY AND CO. Class: Labeling.
Trial registered· ClinicalTrials.gov
Tirzepatide in Idiopathic Intracranial Hypertension Trial
Trial started· ClinicalTrials.gov
Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT)
Trial started· ClinicalTrials.gov
Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder
Sources
FDA approvals, label revisions, and recalls come from the public openFDA APIs (Drugs@FDA, Drug Label, Drug Enforcement). Drug-safety communications come from the FDA RSS feed. Trial milestones come from ClinicalTrials.gov via the AACT pg dump. Pivotal-publication events come from PubMed, filtered to high-impact journals linked to a Phase 3 trial in our inventory.