A Study of Tirzepatide (LY3298176) in Participants With Type 1 Diabetes Mellitus and Overweight or Obesity

Part of paid clinical trials in Miami, Florida.

Sponsor
Eli Lilly and Company
Study ID
NCT07803744
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Tirzepatide — DRUG
    Administered SC.
  • Acetaminophen — DRUG
    Administered orally.
  • Placebo — DRUG
    Administered SC.

Study Details

The main purpose of this study is to learn more how tirzepatide affects stomach emptying in participants with Type 1 Diabetes Mellitus (T1DM) and overweight or obesity. Participation in this study will last about 8 weeks, including screening and follow-up.

Key Dates

First listed
Sep 4, 2026
Start date
Sep 30, 2026
Status verified
Sep 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
18 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Tirzepatide + Acetaminophen
    Participants will receive tirzepatide administered subcutaneously (SC) and acetaminophen administered orally.
  • Placebo Comparator: Placebo + Acetaminophen
    Participants will receive placebo administered SC and acetaminophen administered orally.

Primary Outcome Measure

Pharmacokinetics (PK): Time of Maximum Observed Drug Concentration (Tmax) of Acetaminophen [ Time Frame: Predose on Day 1 through 36 hours post dose ]

Central Contacts

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
    1-317-615-4559
    [email protected]
  • Physicians interested in becoming principal investigators please contact
    [email protected]

Locations (1)

FacilityCityStateZIPSite coordinators
Clinical Pharmacology of MiamiMiamiFlorida33172
(305) 817-2900
Angel Lamas (PRINCIPAL_INVESTIGATOR)

Find similar trials in Miami, FL

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By condition
Type 1 diabetesObesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Clinical Pharmacology of Miami· Miami, FL

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