City of Hope Comprehensive Cancer Center

Clinical research site in Irvine, California · 1000 FIVEPOINT RM 01-006, IRVINE, CA 92618 · (949) 671-4325 · Website

As of September 2026, 9 paid clinical trials are recruiting at City of Hope Comprehensive Cancer Center in Irvine, California. Active studies at this site cover conditions such as Advanced Hodgkin Lymphoma, Advanced Renal Cell Carcinoma and Advanced or Metastatic Renal Cell Carcinoma. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 1, 2026.

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Recruiting clinical trials at City of Hope Comprehensive Cancer Center (9)

Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer

for Urothelial Cancer

133 locations incl. Fayetteville

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07421700·Phase 1, Phase 2·Recruiting·Listed Feb 2026

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Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

for Carcinoma, Renal Cell

109 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07227415·Phase 1, Phase 2·Recruiting·Listed Nov 2025

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MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

for Lumbar Spinal Stenosis

2369 locations incl. Athens

Sponsor: Stryker Instruments

Sex: All·Age: 18+

Code: NCT03072927·Recruiting·Listed Mar 2017

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Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

for Solid Tumors

17 locations incl. Duarte

Sponsor: ORIC Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05315700·Phase 1, Phase 2·Recruiting·Listed Apr 2022

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CATALINA-4: A Study to Investigate the Safety and Efficacy of TORL-1-23 With Chemotherapy Given Before Initial Surgery in Women With Advanced Stage Ovarian Cancer

for FIGO Stage III and IV Ovarian Cancer

7 locations incl. Fullerton

Sponsor: TORL Biotherapeutics, LLC

Sex: Female·Age: 18 - 75

Code: NCT07322094·Phase 1, Phase 2·Recruiting·Listed Jan 2026

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A Phase 1 Study to Evaluate Safety and Efficacy of XER-001 (Amifostine for Nasoduodenal Delivery) in Combination With Sterotactic Body Radiotherapy for Treatment in Patients With Locally Advanced Pancreatic Cancer.

for Locally Advanced Pancreatic Adenocarcinoma

5 locations incl. Duarte

Sponsor: Xerient Pharma

Sex: All·Age: 18+

Code: NCT07157033·Phase 1, Phase 2·Recruiting·Listed Sep 2025

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First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

for Non-Small Cell Lung Cancer

9 locations incl. Duarte

Sponsor: Pierre Fabre Medicament

Sex: All·Age: 18+

Code: NCT06043817·Phase 1, Phase 2·Recruiting·Listed Sep 2023

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Personalized Reduction of Chemotherapy Intensity Through ctDNA Evaluation for the Treatment of Patients With Advanced Hodgkin Lymphoma

for Advanced Hodgkin Lymphoma

6 locations incl. Irvine

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT06745076·Phase 2·Recruiting·Listed Dec 2024

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Phase 2 Study of Combination Tivozanib and Nivolumab in Advanced Non-Clear Cell Renal Cell Carcinoma

for Renal Cell Carcinoma

6 locations incl. Irvine

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06053658·Phase 2·Recruiting·Listed Sep 2023

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More research sites in Irvine

City of Hope at Irvine Lennar (64 trials)
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University of California, Irvine (34 trials)
University of California Irvine (19 trials)
Kaiser Permanente-Irvine (18 trials)
City of Hope Orange County Lennar Foundation Cancer Center (11 trials)
City of Hope - Orange County Lennar Foundation Cancer Center (11 trials)
Irvine Clinical Research (10 trials)
City of Hope (7 trials)
Chao Family Comprehensive Cancer Center and Ambulatory Care (7 trials)

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Paid clinical trials in Irvine, CA · California clinical trials