Cleveland Clinic, Main Campus

Clinical research site in Cleveland, Ohio · Cleveland Clinic Main Campus, 9500 Euclid Ave, Cleveland, OH 44195 · (216) 444-2200 · Website

Part of Cleveland Clinic

As of July 2026, 49 paid clinical trials are recruiting at Cleveland Clinic, Main Campus in Cleveland, Ohio. Active studies at this site cover conditions such as Breast Cancer, Abdominal Wall Hernia and Blood Pressure. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 19, 2026.

Recruiting clinical trials at Cleveland Clinic, Main Campus (49)

Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease

for Proteinuric Kidney Disease

167 locations incl. Alabaster

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 10 - 65

Code: NCT05312879·Phase 2, Phase 3·Recruiting·Listed Apr 2022

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Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)

for Autosomal Dominant Polycystic Kidney Disease (ADPKD)

26 locations incl. Alabaster

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 65

Code: NCT07161037·Phase 2·Recruiting·Listed Sep 2025

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Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)

for Neovascular Age-related Macular Degeneration

51 locations incl. Mesa

Sponsor: AbbVie

Sex: All·Age: 50+

Code: NCT07007065·Phase 3·Recruiting·Listed Jun 2025

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Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

36 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06158841·Phase 3·Recruiting·Listed Dec 2023

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A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata

for Alopecia Areata

39 locations incl. Chula Vista

Sponsor: AbbVie

Sex: All·Age: 12 - 63

Code: NCT06012240·Phase 3·Recruiting·Listed Aug 2023

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A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

for Epithelial Ovarian Cancer

65 locations incl. Birmingham

Sponsor: AbbVie

Sex: Female·Age: 18+

Code: NCT06890338·Phase 2·Recruiting·Listed Mar 2025

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A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

for Geographic Atrophy

45 locations incl. Tucson

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 60+

Code: NCT06635148·Phase 2·Recruiting·Listed Oct 2024

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Pompe Disease Registry Protocol

for Glycogen Storage Disease Type II

74 locations incl. Birmingham

Sponsor: Genzyme, a Sanofi Company

Sex: All·Age: All ages

Code: NCT00231400·Recruiting·Listed Oct 2005

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A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

66 locations incl. Gilbert

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05552222·Phase 3·Recruiting·Listed Sep 2022

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Fabry Disease Registry & Pregnancy Sub-registry

for Fabry Disease

74 locations incl. Birmingham

Sponsor: Genzyme, a Sanofi Company

Sex: All·Age: All ages

Code: NCT00196742·Recruiting·Listed Sep 2005

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A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

for Depression

31 locations incl. Anaheim

Sponsor: AbbVie

Sex: All·Age: 10 - 17

Code: NCT04777357·Phase 3·Recruiting·Listed Mar 2021

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A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction

for Lung Transplant Rejection

32 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06082037·Phase 3·Recruiting·Listed Oct 2023

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A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy

for Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD)

20 locations incl. Loma Linda

Sponsor: Pierre Fabre Medicament

Sex: All·Age: All ages

Code: NCT03394365·Phase 3·Recruiting·Listed Jan 2018

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A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression

for Primary IgA Nephropathy

31 locations incl. Alabaster

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT05797610·Phase 3·Recruiting·Listed Apr 2023

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A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis

for Primary Biliary Cholangitis

30 locations incl. Los Angeles

Sponsor: Mirum Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05050136·Phase 2·Recruiting·Listed Sep 2021

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International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry

for Gaucher Disease

70 locations incl. Phoenix

Sponsor: Genzyme, a Sanofi Company

Sex: All·Age: All ages

Code: NCT00358943·Recruiting·Listed Aug 2006

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A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)

for Chronic Lymphocytic Leukemia

31 locations incl. Tucson

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06428019·Phase 3·Recruiting·Listed May 2024

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A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

for Hypothyroidism

130 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT06345339·Phase 2, Phase 3·Recruiting·Listed Apr 2024

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EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

for Breast Cancer

53 locations incl. Anchorage

Sponsor: Exact Sciences Corporation

Sex: All·Age: 18+

Code: NCT06401421·Recruiting·Listed May 2024

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A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndrome

24 locations incl. Gilbert

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07422480·Phase 3·Recruiting·Listed Feb 2026

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A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)

for Squamous Non-small Cell Lung Cancer

10 locations incl. Tampa

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07221474·Phase 2·Recruiting·Listed Oct 2025

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Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants Undergoing Open Abdominal Ventral Hernia Repair

for Ventral Hernia

10 locations incl. Riverside

Sponsor: AbbVie

Sex: All·Age: 18 - 80

Code: NCT07226791·Phase 2·Recruiting·Listed Nov 2025

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A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease

for Immunoglobulin G4 Related Disease

17 locations incl. Fontana

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT07190196·Phase 3·Recruiting·Listed Sep 2025

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A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

11 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 2 - 17

Code: NCT05995353·Phase 3·Recruiting·Listed Aug 2023

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Open-label Study of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis (sHLH)

for Secondary Hemophagocytic Lymphohistiocytosis (sHLH)

16 locations incl. Birmingham

Sponsor: Electra Therapeutics Inc.

Sex: All·Age: 6+

Code: NCT05416307·Phase 2, Phase 3·Recruiting·Listed Jun 2022

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A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndromes

23 locations incl. Duarte

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06499285·Phase 3·Recruiting·Listed Jul 2024

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Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

for Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

11 locations incl. Centennial

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05327114·Phase 2, Phase 3·Recruiting·Listed Apr 2022

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Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy

for Cardiomyopathy

21 locations incl. Little Rock

Sponsor: Tenaya Therapeutics

Sex: All·Age: 0 - 18

Code: NCT05112237·Recruiting·Listed Nov 2021

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Visugromab in Cachexia International Trial

for Cancer-associated Cachexia

6 locations incl. Clermont

Sponsor: CatalYm GmbH

Sex: All·Age: 18+

Code: NCT07112196·Phase 2, Phase 3·Recruiting·Listed Aug 2025

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Clinical Outcome Measure at Stryker Spine

for Degenerative Disc Disease

7 locations incl. Jacksonville

Sponsor: VB Spine, LLC

Sex: All·Age: 18+

Code: NCT06226272·Recruiting·Listed Jan 2024

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A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS)

for VEXAS

9 locations incl. Scottsdale

Sponsor: Swedish Orphan Biovitrum

Sex: All·Age: 18+

Code: NCT06782373·Phase 2·Recruiting·Listed Jan 2025

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Dietary Tracking in Heart Failure

for Heart Failure

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07649148·Recruiting·Listed Jun 16, 2026

Apply to this trial

Cardiovascular and Metabolic Sciences Biorepository

for Cardiovascular Diseases

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06560424·Recruiting·Listed Aug 2024

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Tocilizumab in Lung Transplantation

for Lung Transplant

17 locations incl. Phoenix

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12 - 75

Code: NCT06033196·Phase 2·Recruiting·Listed Sep 2023

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Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients

for Mobility Limitation

5 locations incl. Springfield

Sponsor: The Cleveland Clinic

Sex: All·Age: 65+

Code: NCT05725928·Recruiting·Listed Feb 2023

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Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients

for Lung Transplant

11 locations incl. Los Angeles

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12+

Code: NCT06476132·Phase 2·Recruiting·Listed Jun 2024

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Evaluating Whether Treating Elevated Blood Pressure in the Inpatient Setting Impacts Patient Outcomes

for Blood Pressure Control

2 locations incl. Cleveland

Sponsor: Elizabeth Pfoh

Sex: All·Age: 18+

Code: NCT07208669·Recruiting·Listed Oct 2025

Apply to this trial

Preoperative BOTOX® Injection for Large Ventral Hernia Repair

for Hernia Abdominal Wall

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07220382·Phase 4·Recruiting·Listed Oct 2025

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Vascular Events In Patients Undergoing Same-day Noncardiac Surgery (VALIANCE) Study

for Preoperative Care

5 locations incl. Winston-Salem

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All·Age: 45+

Code: NCT04973397·Recruiting·Listed Jul 2021

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Evaluation and Further Development of an Artificial Intelligence-based Algorithm for Clinical Decision Support

for Invasive Mechanical Ventilation

1 location in Cleveland

Sponsor: Technische Universität Dresden

Sex: All·Age: 18+

Code: NCT05668637·Recruiting·Listed Dec 2022

Apply to this trial

Showing the 40 most relevant of 49 recruiting trials at this site. Browse all with filters →

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Paid clinical trials in Cleveland, OH · Ohio clinical trials