Harvard University Massachusetts General Hospital

Clinical research site in Boston, Massachusetts · Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 · (617) 726-2000 · Website

Part of Massachusetts General Hospital

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As of September 2026, 35 paid clinical trials are recruiting at Harvard University Massachusetts General Hospital in Boston, Massachusetts. Active studies at this site cover conditions such as Obstructive Hypertrophic Cardiomyopathy, Non-cystic Fibrosis Bronchiectasis and Aortic Valve Regurgitation. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 21, 2026.

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Recruiting clinical trials at Harvard University Massachusetts General Hospital (35)

A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

for Obstructive Hypertrophic Cardiomyopathy

48 locations incl. Anchorage

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05489705·Recruiting·Listed Aug 2022

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A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis

for Non-cystic Fibrosis Bronchiectasis

28 locations incl. Birmingham

Sponsor: Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA

Sex: All·Age: 18 - 80

Code: NCT06559150·Phase 2·Recruiting·Listed Aug 2024

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J-Valve Transfemoral Pivotal Study

for Aortic Valve Regurgitation

34 locations incl. Scottsdale

Sponsor: JC Medical, Inc., an affiliate of Edwards Lifesciences LLC

Sex: All·Age: 18+

Code: NCT06455787·Recruiting·Listed Jun 2024

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PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

for Aortic Stenosis, Calcific

50 locations incl. Huntsville

Sponsor: Edwards Lifesciences

Sex: All·Age: 65+

Code: NCT04889872·Recruiting·Listed May 2021

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Onyx™ Liquid Embolic IDE Clinical Study

for Peripheral Arterial Hemorrhage

18 locations incl. Phoenix

Sponsor: Medtronic Endovascular

Sex: All·Age: 22+

Code: NCT06742801·Recruiting·Listed Dec 2024

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uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto

for Urothelial Carcinoma

22 locations incl. Santa Monica

Sponsor: UroGen Pharma Ltd.

Sex: All·Age: 18+

Code: NCT05874921·Recruiting·Listed May 2023

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A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS)

for Amyotrophic Lateral Sclerosis

1 location in Boston

Sponsor: Biogen

Sex: All·Age: 18+

Code: NCT07259980·Recruiting·Listed Dec 2025

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Phase 1 Study to Evaluate Safety and Antiviral Activity of PBGENE-HBV in Adult Patients With Chronic Hepatitis B

for HEPATITIS B CHRONIC

1 location in Boston

Sponsor: Precision BioSciences, Inc.

Sex: All·Age: 18 - 70

Code: NCT06680232·Phase 1·Recruiting·Listed Nov 2024

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Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

for Treatment Resistant Depression (TRD)

2 locations in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07563868·Recruiting·Listed May 2026

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Parkinson's Foundation PD GENEration Genetic Registry

for Parkinson's Disease

51 locations incl. Phoenix

Sponsor: Parkinson's Foundation

Sex: All·Age: 18+

Code: NCT04994015·Recruiting·Listed Aug 2021

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Promoting Recovery After Brain Injury Using Focused Ultrasound

for Consciousness Disorders

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 79

Code: NCT07277309·Recruiting·Listed Dec 2025

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Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers

for Metastatic Non-small Cell Lung Cancer

15 locations incl. Sacramento

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT04410796·Phase 2·Recruiting·Listed Jun 2020

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Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

for Optic Neuritis

29 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07100990·Phase 3·Recruiting·Listed Aug 2025

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A Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Initiation During Acute HIV Infection to Induce HIV Remission

for Acute HIV Infection

32 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT05719441·Phase 2·Recruiting·Listed Feb 2023

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Tocilizumab in Lung Transplantation

for Lung Transplant

17 locations incl. Phoenix

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12 - 75

Code: NCT06033196·Phase 2·Recruiting·Listed Sep 2023

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A Study of Ruxolitinib in Combination With Ulixertinib in People With Myelofibrosis

for Myelofibrosis

9 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06773195·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

for Esophageal Cancer

10 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06123338·Phase 2·Recruiting·Listed Nov 2023

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Trial-Ready Cohort-Down Syndrome (TRC-DS)

for Down Syndrome

18 locations incl. Phoenix

Sponsor: University of Southern California

Sex: All·Age: 25 - 55

Code: NCT04165109·Recruiting·Listed Nov 2019

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A Registry for People With T-cell Lymphoma

for T-cell Lymphoma

26 locations incl. Duarte

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: All ages

Code: NCT05978141·Recruiting·Listed Aug 2023

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Ultrasound Stimulation for Patients in a Disorder of Consciousness

for Consciousness Disorders

4 locations incl. Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 79

Code: NCT06939348·Recruiting·Listed Apr 2025

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Addressing Emotional Distress in Dyads of Persons With a Young Onset Dementia (YOD) and Their Care-partners

for Young Onset Dementia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07018726·Recruiting·Listed Jun 2025

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Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers

for Lung Carcinoma

16 locations incl. Davis

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06196008·Recruiting·Listed Jan 2024

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A Novel Digital Application (SHIFT) to Improve Outcomes for Hematopoietic Stem Cell Transplant Survivors

for Sexual Dysfunction

3 locations incl. Coral Gables

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06541002·Recruiting·Listed Aug 2024

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The Myelin Disorders Biorepository Project

for Leukodystrophy

23 locations incl. Los Angeles

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT03047369·Recruiting·Listed Feb 2017

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Cannabis, Linked Emotions, and Adolescent Risk Study

for Cannabis Use

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 12 - 18

Code: NCT06576076·Recruiting·Listed Aug 2024

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Rare and Atypical Diabetes Network

for Diabetes Mellitus

13 locations incl. Aurora

Sponsor: University of South Florida

Sex: All·Age: All ages

Code: NCT05544266·Recruiting·Listed Sep 2022

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Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2

for Charcot-Marie-Tooth Disease, Type Ia (Disorder)

17 locations incl. Los Angeles

Sponsor: University of Iowa

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01193088·Recruiting·Listed Sep 2010

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Novel Digital Application for Patients With Acute Leukemia

for Relapsed Adult Acute Myeloid Leukemia

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 120

Code: NCT06472128·Recruiting·Listed Jun 2024

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Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment

for Adhesive Capsulitis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT02283996·Phase 4·Recruiting·Listed Nov 2014

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Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)

for Brainstem Stroke

1 location in Boston

Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All·Age: 18 - 80

Code: NCT06511934·Recruiting·Listed Jul 2024

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Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others

for Charcot Marie Tooth Disease

18 locations incl. Los Angeles

Sponsor: Michael Shy

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01193075·Recruiting·Listed Sep 2010

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Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS

for Unstable Blood Pressure

2 locations in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 24 Weeks - 44 Weeks

Code: NCT06994494·Recruiting·Listed May 2025

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Epidermal Skin Grafts to Improve Healing In Radiation Wounds

for Radiation Dermatitis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT04560803·Recruiting·Listed Sep 2020

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Circulating Tumor Cell Analysis in Patients With Localized Prostate Cancer Undergoing Prostatectomy

for Prostate Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Male·Age: 18+

Code: NCT01961713·Recruiting·Listed Oct 2013

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Use of BMAC With Hip Arthroscopy Treatment of FAI and Labral Tear

for Acetabular Labrum Tear

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03909139·Recruiting·Listed Apr 2019

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