Roswell Park Cancer Institute

Clinical research site in Buffalo, New York · ELM AND CARLTON ST, BUFFALO, NY 14263 · (716) 845-2300

Part of Roswell Park Comprehensive Cancer Center

As of July 2026, 159 paid clinical trials are recruiting at Roswell Park Cancer Institute in Buffalo, New York. Active studies at this site cover conditions such as Acute Myeloid Leukemia, Malignant Solid Neoplasm and Recurrent Fallopian Tube Carcinoma. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 19, 2026.

Recruiting clinical trials at Roswell Park Cancer Institute (159)

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

for Ovarian Neoplasms

88 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07213804·Phase 3·Recruiting·Listed Oct 2025

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A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

for Lymphoma, Large B-Cell, Diffuse

71 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06890884·Phase 2·Recruiting·Listed Mar 2025

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Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells

for Neoplasms

77 locations incl. Birmingham

Sponsor: Celgene

Sex: All·Age: All ages

Code: NCT03435796·Phase 2, Phase 3·Recruiting·Listed Feb 2018

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Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

for NSCLC (Non-small Cell Lung Cancer)

43 locations incl. Birmingham

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06881784·Phase 3·Recruiting·Listed Mar 2025

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A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

for Chronic Lymphocytic Leukemia

43 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06136559·Phase 3·Recruiting·Listed Nov 2023

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A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

for Carcinoma, Non-Small-Cell Lung

48 locations incl. Gilbert

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06623422·Phase 3·Recruiting·Listed Oct 2024

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A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel

for Multiple Myeloma

28 locations incl. Phoenix

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05201781·Phase 4·Recruiting·Listed Jan 2022

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Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

for Pancreatic Neuroendocrine Tumor (pNET)

40 locations incl. Birmingham

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT06943755·Phase 2, Phase 3·Recruiting·Listed Apr 2025

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VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

for Advanced Melanoma

44 locations incl. Gilbert

Sponsor: Replimune, Inc.

Sex: All·Age: 12+

Code: NCT06264180·Phase 3·Recruiting·Listed Feb 2024

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A Study of ASP3082 in Adults With Advanced Solid Tumors

for Solid Tumor

24 locations incl. Duarte

Sponsor: Astellas Pharma Inc

Sex: All·Age: 18+

Code: NCT05382559·Phase 1·Recruiting·Listed May 2022

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A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

48 locations incl. Birmingham

Sponsor: Celgene

Sex: Male·Age: 18+

Code: NCT06764485·Phase 3·Recruiting·Listed Jan 2025

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A Trial to Evaluate Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade BCG Unresponsive Non-muscle Invasive Bladder Cancer

for Non-muscle Invasive Bladder Cancer With Carcinoma in Situ

39 locations incl. Tucson

Sponsor: Ferring Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06545955·Phase 3·Recruiting·Listed Aug 2024

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Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

38 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06297226·Phase 2·Recruiting·Listed Mar 2024

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Pan Tumor Rollover Study

for Cancer

8 locations incl. Louisville

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT03899155·Phase 2·Recruiting·Listed Apr 2019

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A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

for Low Grade Serous Ovarian Cancer

38 locations incl. Phoenix

Sponsor: Verastem, Inc.

Sex: Female·Age: 18+

Code: NCT06072781·Phase 3·Recruiting·Listed Oct 2023

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Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread

for Metastatic Urothelial Cancer

27 locations incl. Tucson

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT03547973·Phase 2·Recruiting·Listed Jun 2018

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MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

for Breast Cancer

113 locations incl. Anchorage

Sponsor: Agendia

Sex: All·Age: 18+

Code: NCT03053193·Recruiting·Listed Feb 2017

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LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

for Superficial Bladder Cancer

48 locations incl. Birmingham

Sponsor: enGene, Inc.

Sex: All·Age: 18+

Code: NCT04752722·Phase 1, Phase 2·Recruiting·Listed Feb 2021

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A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors

for Advanced Solid Tumor

15 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06997029·Phase 1·Recruiting·Listed May 2025

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A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

for Multiple Myeloma

15 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06121843·Phase 1·Recruiting·Listed Nov 2023

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A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

for Solid Tumor

11 locations incl. Santa Monica

Sponsor: Astellas Pharma Inc

Sex: All·Age: 18+

Code: NCT07094204·Phase 1·Recruiting·Listed Jul 2025

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(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

for Indolent Systemic Mastocytosis

14 locations incl. Birmingham

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT04910685·Phase 2, Phase 3·Recruiting·Listed Jun 2021

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Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

22 locations incl. Birmingham

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06343402·Phase 1·Recruiting·Listed Apr 2024

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A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With REGN5678 for Adult Participants With Advanced Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

13 locations incl. Palo Alto

Sponsor: Regeneron Pharmaceuticals

Sex: Male·Age: 18+

Code: NCT05125016·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

for Breast Cancer

15 locations incl. Orlando

Sponsor: Incyclix Bio

Sex: All·Age: 18+

Code: NCT05735080·Phase 1, Phase 2·Recruiting·Listed Feb 2023

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A Study of Tagraxofusp in Combination With Venetoclax and Azacitidine in Adults With Untreated CD123+ Acute Myeloid Leukemia Who Cannot Undergo Intensive Chemotherapy

for Acute Myeloid Leukemia

24 locations incl. Los Angeles

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06456463·Phase 2·Recruiting·Listed Jun 2024

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Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma

for Relapsed or Refractory T Cell Lymphoma

19 locations incl. Duarte

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT05079282·Phase 1·Recruiting·Listed Oct 2021

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CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

for Relapsed/Refractory Acute Myeloid Leukemia (AML)

9 locations incl. Birmingham

Sponsor: Cullinan Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT05143996·Phase 1·Recruiting·Listed Dec 2021

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A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.

for Endometrial Cancer

12 locations incl. Phoenix

Sponsor: Iovance Biotherapeutics, Inc.

Sex: Female·Age: 18 - 70

Code: NCT06481592·Phase 2·Recruiting·Listed Jul 2024

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A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

for Leukemia

13 locations incl. Duarte

Sponsor: BlossomHill Therapeutics

Sex: All·Age: 18+

Code: NCT06501196·Phase 1·Recruiting·Listed Jul 2024

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A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)

for Small Cell Lung Cancer

9 locations incl. Aurora

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06780137·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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Isatuximab in Combination With Novel Agents in RRMM - Master Protocol

for Plasma Cell Myeloma Refractory

4 locations incl. Atlanta

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT04643002·Phase 1, Phase 2·Recruiting·Listed Nov 2020

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A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

for Non Small Cell Lung Cancer

8 locations incl. Orlando

Sponsor: Compass Therapeutics

Sex: All·Age: 18+

Code: NCT06150664·Phase 1·Recruiting·Listed Nov 2023

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This is a Phase 1 Study to Evaluate the Safety of LTZ-301 in Patients With Non-Hodgkin Lymphoma

for Non-Hodgkin Lymphoma Refractory/ Relapsed

5 locations incl. Duarte

Sponsor: LTZ Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07121946·Phase 1·Recruiting·Listed Aug 2025

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A Phase I Study of SIM0505 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

9 locations incl. Orlando

Sponsor: NextCure, Inc.

Sex: All·Age: 18+

Code: NCT06792552·Phase 1·Recruiting·Listed Jan 2025

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A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers

for Epithelial Ovarian Cancer

5 locations incl. Boston

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06469281·Phase 1·Recruiting·Listed Jun 2024

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CraniSeal Post Approval Study

for Leak, Cerebrospinal Fluid

7 locations incl. Jacksonville

Sponsor: Pramand LLC

Sex: All·Age: 18+

Code: NCT06406790·Phase 4·Recruiting·Listed May 2024

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Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

for Cancer

6 locations incl. Scottsdale

Sponsor: Simcha IL-18, Inc.

Sex: All·Age: 18+

Code: NCT04787042·Phase 1, Phase 2·Recruiting·Listed Mar 2021

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Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

for Anatomic Stage II Breast Cancer AJCC v8

64 locations incl. Jonesboro

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07391774·Phase 3·Recruiting·Listed Feb 2026

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Understanding Tobacco and Cannabis Co-Use Practices: Initiation, Escalation, and Maintenance

for Cigarette Smoking-Related Carcinoma

1 location in Buffalo

Sponsor: Roswell Park Cancer Institute

Sex: All·Age: 18 - 30

Code: NCT07439471·Recruiting·Listed Feb 2026

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Showing the 40 most relevant of 159 recruiting trials at this site. Browse all with filters →

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Paid clinical trials in Buffalo, NY · New York clinical trials