Clinical Trials at National Institutes of Health Clinical Center

As of July 2026, 593 paid clinical trials are recruiting at National Institutes of Health Clinical Center, located at 10 CENTER DR, BLDG. 10 ROOM 2-5940, BETHESDA, MD 20892-0001, phone (301) 496-6353 in Bethesda, Maryland. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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599 clinical trials at National Institutes of Health Clinical Center

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Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

for Alcohol Use Disorder

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 21 - 70

Code: NCT07027839·Phase 1·Recruiting·Listed Jun 2025

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Clinical and Molecular Studies in Families With Inherited Eye Disease

for Inherited Eye Disease

Sites in Bethesda +1 more location

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 4 - 120

Code: NCT02771236·Recruiting·Listed May 2016

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Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

for Severe Aplastic Anemia

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 4 - 80

Code: NCT01174108·Phase 2·Recruiting·Listed Aug 2010

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The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States

for Dysphagia

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 65

Code: NCT07027826·Recruiting·Listed Jun 2025

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Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants

for Germline Mutation

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 Month - 120

Code: NCT07019155·Recruiting·Listed Jun 2025

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Tirzepatide in MetALD

for Metabolic Alcohol-associated Liver Disease

Drug: Tirzepatide

1 location in Bethesda

Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Sex: All·Age: 21 - 100

Code: NCT07046819·Phase 2·Recruiting·Listed Jul 2025

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Genome Transplant Dynamics

for Thoracic Organ Transplantation

Sites in Bethesda, Baltimore +1 more location

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 14 - 80

Code: NCT02423070·Recruiting·Listed Apr 2015

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Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults

for Muscle Weakness

1 location in Bethesda

Sponsor: National Institutes of Health Clinical Center (CC)

Sex: All·Age: 5 - 25

Code: NCT06998134·Recruiting·Listed May 2025

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E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

for Cervical Cancer

Sites in Bethesda +2 more locations

Sponsor: Christian Hinrichs

Sex: All·Age: 18+

Code: NCT05686226·Phase 2·Recruiting·Listed Jan 2023

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Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

for Autoimmune Disease

Drug: Nivolumab

Sites in Bethesda, Baltimore +39 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03816345·Phase 1·Recruiting·Listed Jan 2019

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PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)

for Long COVID

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06920628·Phase 1·Recruiting·Listed Apr 2025

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Evaluating the Dose, Safety, Tolerability, and Immunogenicity of Mosaic Hexavalent Influenza Vaccine VRCFLUMOS0116-00-VP (FluMos-v2) With and Without ALFQ Adjuvant in Healthy Adults

for Influenza Prevention

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06863142·Phase 1·Recruiting·Listed Mar 2025

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Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers

for Healthy

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 101·Accepts healthy volunteers

Code: NCT06874205·Phase 1·Recruiting·Listed Mar 2025

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Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency

for Premature Ovarian Insufficiency

1 location in Bethesda

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: Female·Age: 11 - 19·Accepts healthy volunteers

Code: NCT06851754·Phase 3·Recruiting·Listed Feb 2025

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Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

for Malignancy, Hematologic

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06904066·Phase 1·Recruiting·Listed Apr 2025

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Lenacapavir Intensification to Disrupt HIV Reservoirs in Virologically Suppressed People With HIV Receiving Antiretroviral Therapy

for Human Immunodeficiency Virus

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT06819176·Phase 1·Recruiting·Listed Feb 2025

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A Biorepository of Multiple Allergic Diseases (MADREP) With Longitudinal Follow-Up

for Allergy, Sinus Disorders, Atopic Diseases, Asthma, Allergic Rhinitis, Atopic Dermatitis, EoE, Drug a

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 3 - 100

Code: NCT06732414·Recruiting·Listed Dec 2024

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An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Primary Focal Segmental Glomerulosclerosis

for Focal Segmental Glomerulosclerosis

1 location in Bethesda

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 18 - 115

Code: NCT06664814·Phase 2·Recruiting·Listed Oct 2024

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Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Leukemias

for Leukemia, Lymphocytic, Chronic, B-Cell

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06364423·Phase 1, Phase 2·Recruiting·Listed Apr 2024

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Evaluation of Late Effects and Natural History of Disease in Patients Treated With Radiotherapy

for Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT00026650·Recruiting·Listed Nov 2001

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Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders

for Mood Disorders

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT00397111·Recruiting·Listed Nov 2006

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Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)

for Immunosuppression

1 location in Bethesda

Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)

Sex: All·Age: 7 - 100·Accepts healthy volunteers

Code: NCT01568697·Recruiting·Listed Apr 2012

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Natural History of Noncirrhotic Portal Hypertension

for Cystic Fibrosis

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 12 - 100

Code: NCT02417740·Recruiting·Listed Apr 2015

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Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs)

for Neurofibromatosis 1

Sites in Bethesda +1 more location

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT02544022·Recruiting·Listed Sep 2015

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Natural History Study of CADASIL

for Cardiovascular Disease

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05072483·Recruiting·Listed Oct 2021

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Longitudinal Early Advance Care Planning Discussions and Documentation (LEADD) Program: An Exploratory Study in Adolescents and Young Adults (AYAs) Receiving Hematopoietic Stem Cell Transplant

for Hematopoietic Stem Cell Transplantation

Sites in Bethesda & Baltimore

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT05605574·Recruiting·Listed Nov 2022

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Surface Electrical Stimulation for Urinary Incontinence in Men Treated for Prostate Cancer

for Urinary Urge Incontinence

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18 - 120

Code: NCT06161506·Phase 2·Recruiting·Listed Dec 2023

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Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

for Nephrotic Syndrome

Drug: Rituximab

2 locations in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 90

Code: NCT00977977·Phase 2·Recruiting·Listed Sep 2009

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Collection of Blood From Patients With Cancer

for Prostate Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00034216·Recruiting·Listed Apr 2002

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Detection and Characterization of Infections and Infection Susceptibility

for Immune Deficiencies

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 1 Month - 100

Code: NCT00404560·Recruiting·Listed Nov 2006

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Imaging Studies to Check the Local Response of Prostate Cancer to Radiation Therapy

for Prostatic Neoplasms

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18 - 120

Code: NCT01834001·Recruiting·Listed Apr 2013

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Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions

for Still's Disease, Adult-Onset

1 location in Bethesda

Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Sex: All·Age: 1 Day - 100·Accepts healthy volunteers

Code: NCT03510442·Recruiting·Listed Apr 2018

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18F-DCFPyL Imaging as a Method to Assess Treatment Response to Stereotactic Body Radiation Therapy

for Localized Prostate Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18 - 120

Code: NCT05155046·Phase 2·Recruiting·Listed Dec 2021

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Focal Therapy With Stereotactic Body Radiation Therapy (SBRT) for Patients With a Single Prostate Tumor

for Prostatic Neoplasms

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18 - 120

Code: NCT05616650·Phase 2·Recruiting·Listed Nov 2022

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Enzalutamide and PDS01ADC in PET Positive Recurrent Prostate Cancer (pprPC) Without Testosterone Lowering Therapy

for Prostate Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18 - 120

Code: NCT06096870·Phase 2·Recruiting·Listed Oct 2023

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Studies of Blood Flow to the Brain During Thought

for Healthy Volunteer

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT00001360·Recruiting·Listed Nov 1999

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Evaluation, Treatment, and Follow-up of Patients With Lyme Disease

for Lyme Disease

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 2 - 99

Code: NCT00028080·Recruiting·Listed Dec 2001

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Top-Down Attentional Control of Visual-Processing

for Focal Brain Lesion

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT01087281·Recruiting·Listed Mar 2010

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Diagnosis and Treatment of Patients With Inborn Errors of Metabolism

for Arterial Calcification Due to Deficiency of CD73

1 location in Bethesda

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 115·Accepts healthy volunteers

Code: NCT00369421·Recruiting·Listed Aug 2006

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Study of Factors Regulating Mast Cell Proliferation

for Mastocytosis

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 1 Day - 80·Accepts healthy volunteers

Code: NCT00044122·Recruiting·Listed Aug 2002

Apply to this trial