Brain disorders Clinical Trials in Boston, MA

As of August 2026, 118 paid clinical trials are recruiting for Brain disorders in Boston, Massachusetts. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

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121 clinical trials for Brain disorders

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

Sites in Boston +90 more locations

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting·Listed Feb 2020

Apply to this trial

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

for Autoimmune Disease

Drug: Nivolumab

Sites in Boston +40 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03816345·Phase 1·Recruiting·Listed Jan 2019

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ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in Boston +35 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting·Listed Aug 2024

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Genetic and Environmental Risk Factors for Hemorrhagic Stroke

for Stroke

Sites in Boston +6 more locations

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00682695·Recruiting·Listed May 2008

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CTSN Embolic Protection Trial

for Delirium

Sites in Boston +18 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting·Listed Sep 2023

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

Sites in Boston, Burlington +140 more locations

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting·Listed Apr 2019

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Dominantly Inherited Alzheimer Network (DIAN)

for Alzheimer's Disease

Sites in Boston +6 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00869817·Recruiting·Listed Mar 2009

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Telerehabilitation In The Home After Stroke

for Stroke

Sites in Boston, Charlestown +25 more locations

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 80

Code: NCT06682429·Recruiting·Listed Nov 2024

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An Augmented Reality Based System for Neglect Detection, Assessment, and Rehabilitation

for Stroke

Sites in Boston +1 more location

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT04187131·Recruiting·Listed Dec 2019

Apply to this trial

PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

for Parkinson Disease

Sites in Boston +29 more locations

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT04477785·Recruiting·Listed Jul 2020

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Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline

for Chronic Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50+

Code: NCT06246929·Recruiting·Listed Feb 2024

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Natural History Study of Synucleinopathies

for Patients With Synucleinopathies

Sites in Boston +4 more locations

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT01799915·Recruiting·Listed Feb 2013

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Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis

for Multiple Sclerosis

1 location in Boston

Sponsor: MGH Institute of Health Professions

Sex: All·Age: 25 - 75

Code: NCT06136728·Phase 3·Recruiting·Listed Nov 2023

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Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia

for Anarthria

Sites in Boston +1 more location

Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All·Age: 18 - 80

Code: NCT05724173·Recruiting·Listed Feb 2023

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BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

for Tetraplegia

Sites in Boston +5 more locations

Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All·Age: 18 - 80

Code: NCT00912041·Recruiting·Listed Jun 2009

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Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People at Risk for Alzheimer's Disease

for Alzheimer Disease

Sites in Boston & Cambridge

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05776641·Recruiting·Listed Mar 2023

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Trial-Ready Cohort-Down Syndrome (TRC-DS)

for Down Syndrome

Sites in Boston +17 more locations

Sponsor: University of Southern California

Sex: All·Age: 25 - 55

Code: NCT04165109·Recruiting·Listed Nov 2019

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Effectiveness of Cognitive Training in Older and Younger Adults

for Cognitive Change

Sites in Boston +2 more locations

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT06375681·Recruiting·Listed Apr 2024

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Assessment of a Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors

for Stroke

1 location in Boston

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 21 - 80

Code: NCT02896348·Recruiting·Listed Sep 2016

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Care in Multiple Sclerosis (MS)

for Multiple Sclerosis

Sites in Boston +5 more locations

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07011914·Recruiting·Listed Jun 2025

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EIM Via the Myolex mScan as an ALS Biomarker

for Amyotrophic Lateral Sclerosis

Sites in Boston +5 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06491732·Recruiting·Listed Jul 2024

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Statins In Intracerbral Hemorrhage

for Intracerebral Hemorrhage

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 50+

Code: NCT03936361·Phase 3·Recruiting·Listed May 2019

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Computational Neuroscience of Language Processing in the Human Brain

for Language

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT05222594·Recruiting·Listed Feb 2022

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Treatment With Endovascular Intervention for STroke Patients With Existing Disability

for Stroke

Sites in Boston +24 more locations

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05911568·Recruiting·Listed Jun 2023

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Cognitive Neurology Unit Clinical Registry

for Alzheimer Disease

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 50 - 95

Code: NCT05925621·Recruiting·Listed Jun 2023

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Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

for Alzheimer Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 99·Accepts healthy volunteers

Code: NCT06538311·EARLY_Phase 1·Recruiting·Listed Aug 2024

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Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits

for Epilepsy

Sites in Boston +3 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04419272·Phase 4·Recruiting·Listed Jun 2020

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Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

for Seizures

1 location in Boston

Sponsor: Ayal A. Aizer, MD

Sex: All·Age: 18+

Code: NCT07130786·Phase 2·Recruiting·Listed Aug 2025

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Stroke Thrombectomy and Aneurysm Registry

for Stroke

Sites in Boston +53 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting·Listed Aug 2021

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Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons

for Parkinson Disease

1 location in Boston

Sponsor: Jeffrey S. Schweitzer, MD, PhD

Sex: All·Age: 45 - 80

Code: NCT06687837·Phase 1·Recruiting·Listed Nov 2024

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Substrates for Post-Stroke Arm Rehabilitation

for Stroke Rehabilitation

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06998485·Recruiting·Listed May 2025

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A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes

for Epilepsy in Children

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0 - 18

Code: NCT06585605·Recruiting·Listed Sep 2024

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Cortical-Basal Ganglia Speech Networks

for Parkinson Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT04286308·Recruiting·Listed Feb 2020

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Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

for Subjective Cognitive Concerns

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05881239·Recruiting·Listed May 2023

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TMS for Cognitive Decline in Aging and Preclinical AD

for Prodromal Alzheimer&#39

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 99·Accepts healthy volunteers

Code: NCT06956300·Recruiting·Listed May 2025

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Executive Function Training for Children and Adolescents

for Cognitive Change

1 location in Boston

Sponsor: Northeastern University

Sex: All·Age: 12 - 17·Accepts healthy volunteers

Code: NCT07147894·Recruiting·Listed Aug 2025

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Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

Sites in Boston +27 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting·Listed Jun 2021

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Glucose Consumption in MS Using [F-18]FDG-PET

for Multiple Sclerosis

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT07087106·Phase 4·Recruiting·Listed Jul 2025

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StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

Sites in Boston +40 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting·Listed Mar 2024

Apply to this trial

Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

for Delirium, Postoperative

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 70+

Code: NCT06052397·Recruiting·Listed Sep 2023

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Conditions in Brain disorders (Boston, MA)

Stroke· 30 Alzheimer's disease· 20 Parkinson's disease· 19 Epilepsy· 17 ALS (amyotrophic lateral sclerosis)· 14 Multiple sclerosis· 13 Mild cognitive impairment (MCI)· 12 Dementia· 10 Cognitive impairment / decline· 8 Myasthenia gravis· 6 Traumatic brain injury (TBI)· 5 Essential tremor· 3 Huntington disease· 1 Aphasia· 1