Breast cancer Clinical Trials in Boston, MA

As of August 2026, 72 paid clinical trials are recruiting for Breast cancer in Boston, Massachusetts. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

Related specialties in Boston

Oncology· 1,141 Women's health· 193 Breast oncology· 144

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73 clinical trials for Breast cancer

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The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer

for Breast Cancer Female

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06439693·Phase 2·Recruiting·Listed Jun 2024

Apply to this trial

DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs

for Breast Cancer

Sites in Boston +2 more locations

Sponsor: Nancy Lin, MD

Sex: All·Age: 18+

Code: NCT06176261·Phase 2·Recruiting·Listed Dec 2023

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Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

for Breast Atypical Ductal Hyperplasia

Sites in Boston +9 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18 - 55

Code: NCT06184750·Phase 2·Recruiting·Listed Dec 2023

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Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer

for Impaired Cognition

Sites in Boston & Salem

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 60+·Accepts healthy volunteers

Code: NCT02290834·Recruiting·Listed Nov 2014

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Screening For BCRL In Targeted Therapy For Breast Cancer

for Lymphedema

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 80

Code: NCT05142800·Recruiting·Listed Dec 2021

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TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients

for Breast Cancer

Sites in Boston +3 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 65+

Code: NCT05535192·Recruiting·Listed Sep 2022

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Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

for Brain Cancer

2 locations in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT04899908·Phase 2·Recruiting·Listed May 2021

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Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

for Breast Cancer

Sites in Boston, Foxborough +13 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04468061·Phase 2·Recruiting·Listed Jul 2020

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Individualizing Approaches to Surveillance Mammography in Older Breast Cancer Survivors - The I-MAMMO Study

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 80+·Accepts healthy volunteers

Code: NCT07123649·Phase 2·Recruiting·Listed Aug 2025

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Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial

for Breast Cancer

Sites in Boston +6 more locations

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT03990896·Phase 2·Recruiting·Listed Jun 2019

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Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

for Breast Cancer

Drug: Atezolizumab

Sites in Boston +3 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04434040·Phase 2·Recruiting·Listed Jun 2020

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Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

for Breast Cancer

Sites in Boston +6 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04841148·Phase 2·Recruiting·Listed Apr 2021

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VS-6766+Abema+Fulv in Met HR+/HER- BC

for Breast Cancer

2 locations in Boston

Sponsor: Adrienne G. Waks

Sex: All·Age: 18+

Code: NCT05608252·Phase 1, Phase 2·Recruiting·Listed Nov 2022

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Exercise in Metastatic Breast Cancer: EMBody

for Breast Cancer

Sites in Boston +1 more location

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT05468034·Recruiting·Listed Jul 2022

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SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers

for Breast Cancer

Sites in Boston, Weymouth +9 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06896474·Recruiting·Listed Mar 2025

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Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

for Breast Carcinoma

Drug: Bevacizumab

1 location in Boston

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT02610413·Recruiting·Listed Nov 2015

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Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Congestive Heart Failure Receiving Therapy for Breast Cancer

for Breast Carcinoma

1 location in Boston

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT02610426·Recruiting·Listed Nov 2015

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Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Peripheral Neuropathy Receiving Paclitaxel for Breast Cancer

for Breast Carcinoma

1 location in Boston

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT02610439·Recruiting·Listed Nov 2015

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Screening Magnetic Resonance Imaging of the Brain in Patients With Breast Cancer

for Breast Cancer

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT04030507·Recruiting·Listed Jul 2019

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Refining Local-Regional Therapy for IBC

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18+

Code: NCT04636710·Recruiting·Listed Nov 2020

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Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18 - 59·Accepts healthy volunteers

Code: NCT06322888·Recruiting·Listed Mar 2024

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Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer

for Breast Cancer

Drug: Olaparib

3 locations in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06488378·Phase 1·Recruiting·Listed Jul 2024

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Strength After Breast Cancer

for Breast Cancer

1 location in Boston

Sponsor: MGH Institute of Health Professions

Sex: Female·Age: 18+

Code: NCT06052488·Recruiting·Listed Sep 2023

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The COMPASSION Study

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06507930·Recruiting·Listed Jul 2024

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TRUDI: TDXD+Durva in HER2+/Low IBC

for Invasive Breast Cancer

Sites in Boston +2 more locations

Sponsor: Filipa Lynce, MD

Sex: Female·Age: 18+

Code: NCT05795101·Phase 2·Recruiting·Listed Apr 2023

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Video Education With Result Dependent dIsclosure

for Genetic Testing

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05225428·Recruiting·Listed Feb 2022

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Supporting Health Including Endocrine Treatment for Long Duration

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18 - 49

Code: NCT07482384·Recruiting·Listed Mar 2026

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A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

for Breast Cancer

Sites in Boston +9 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05123482·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors

for Breast Cancer

Sites in Boston +11 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT05307705·Phase 1·Recruiting·Listed Apr 2022

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A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for Non-small Cell Lung Cancer

Sites in Boston +13 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05877599·Phase 1·Recruiting·Listed May 2023

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A Long-term Treatment Extension Study of Niraparib in Participants Who Completed a Prior GlaxoSmithKline/TESARO-sponsored Niraparib Study

for Ovarian Neoplasms

Drug: Niraparib

Sites in Boston +8 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT04641247·Phase 2·Recruiting·Listed Nov 2020

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Real-Time Assessment Of Breast Cancer Lumpectomy Specimen Margins With Nonlinear Microscopy

for Breast Cancer

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: Female·Age: 21+

Code: NCT02926729·Recruiting·Listed Oct 2016

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