Mental health Clinical Trials in Boston, MA

As of September 2026, 90 paid clinical trials are recruiting for Mental health in Boston, Massachusetts. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 1, 2026.

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91 clinical trials for Mental health

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CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy

for Obsessive-Compulsive Disorder

Sites in Boston +1 more location

Sponsor: Jasper A. Smits

Sex: All·Age: 18 - 70

Code: NCT05467683·Recruiting·Listed Jul 2022

Apply to this trial

CLOZAPINE Response in Biotype-1

for Schizophrenia

Sites in Boston +4 more locations

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 60

Code: NCT04580134·Phase 4·Recruiting·Listed Oct 2020

Apply to this trial

Triage Survey for Psychiatry Research Eligibility

for Major Depressive Disorder

Sites in Boston, Watertown +4 more locations

Sponsor: Adams Clinical

Sex: All·Age: 18+

Code: NCT05800925·Recruiting·Listed Apr 2023

Apply to this trial

Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

for Depression - Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06878859·Recruiting·Listed Mar 2025

Apply to this trial

Treatment for Antepartum Posttraumatic Stress Disorder/PTSD Study

for PTSD

1 location in Boston

Sponsor: Boston University

Sex: Female·Age: 18 - 50

Code: NCT05486793·Recruiting·Listed Aug 2022

Apply to this trial

Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients

for Insomnia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65+

Code: NCT06375265·Recruiting·Listed Apr 2024

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A Hybrid Effectiveness Implementation Trial Evaluating Behavioral Treatments for Insomnia for Socioeconomically Disadvantaged Adults in Primary Care

for Insomnia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05759065·Recruiting·Listed Mar 2023

Apply to this trial

Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

for PTSD

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07260032·Recruiting·Listed Dec 2025

Apply to this trial

Buspirone and Melatonin for Depression Following Traumatic Brain Injury

for Depression

Sites in Boston & Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 64

Code: NCT04400266·Phase 4·Recruiting·Listed May 2020

Apply to this trial

Music Use in Parturients Admitted to Labor & Delivery

for Anxiety

1 location in Boston

Sponsor: Tufts Medical Center

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06969105·Recruiting·Listed May 2025

Apply to this trial

The Effect of Sleep Loss on Emotion Regulation

for Sleep

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT05393830·Recruiting·Listed May 2022

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Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

for Schizophrenia Spectrum and Other Psychotic Disorders

Sites in Boston, Belmont +4 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 40

Code: NCT06740383·Recruiting·Listed Dec 2024

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A Study of a Novel EEG Neurofeedback System for PTSD Treatment

for Stress Disorders, Post-Traumatic

Sites in Boston +5 more locations

Sponsor: Foundation for Atlanta Veterans Education and Research, Inc.

Sex: All·Age: 18 - 65

Code: NCT06770998·Recruiting·Listed Jan 2025

Apply to this trial

Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication

for Stress Disorders, Post-Traumatic

1 location in Boston

Sponsor: Boston University

Sex: All·Age: 18+

Code: NCT06088303·Recruiting·Listed Oct 2023

Apply to this trial

CF Wellness Program

for Cystic Fibrosis (CF)

Sites in Boston +2 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT07071324·Recruiting·Listed Jul 2025

Apply to this trial

Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners

for Nursing Home Resident

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07220486·Recruiting·Listed Oct 2025

Apply to this trial

Family Involvement in Treatment for PTSD (FIT-PTSD): A Brief, Feasible Method for Enhancing Outcomes, Retention, and Engagement

for Posttraumatic Stress Disorder

Sites in Boston +2 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05267665·Recruiting·Listed Mar 2022

Apply to this trial

A Multicenter Pediatric Deep Brain Stimulation Registry

for Dystonia

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0 - 18

Code: NCT06585618·Recruiting·Listed Sep 2024

Apply to this trial

A Mixed Methods Pilot Trial of the STEP Home Workshop to Improve Reintegration and Reduce Suicide Risk for Recently Transitioned Veterans

for TBI

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05995678·Recruiting·Listed Aug 2023

Apply to this trial

Cannabis, Linked Emotions, and Adolescent Risk Study

for Cannabis Use

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 12 - 18

Code: NCT06576076·Recruiting·Listed Aug 2024

Apply to this trial

Enhanced Coordinated Specialty Care for Early Psychosis

for Psychosis

Sites in Boston, Cambridge +3 more locations

Sponsor: Mclean Hospital

Sex: All·Age: All ages

Code: NCT06071858·Recruiting·Listed Oct 2023

Apply to this trial

Suicide Risk Interventions

for Suicide

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05931289·Phase 2·Recruiting·Listed Jul 2023

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Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

for Generalized Anxiety Disorder

Sites in Boston +2 more locations

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 65

Code: NCT04557891·Recruiting·Listed Sep 2020

Apply to this trial

Promoting Resilience in Early Survivorship Among Adolescents and Young Adults With Cancer

for Stress

2 locations in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 12 - 25·Accepts healthy volunteers

Code: NCT06038318·Recruiting·Listed Sep 2023

Apply to this trial

Expressive Writing on Minority Stressors Among Sexual Minority Veterans

for Depressive Symptoms

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05897021·Recruiting·Listed Jun 2023

Apply to this trial

AWARE: Management of ADHD in Autism Spectrum Disorder

for ADHD

Sites in Boston +9 more locations

Sponsor: Daniel Coury

Sex: All·Age: 4 - 17

Code: NCT05916339·Phase 4·Recruiting·Listed Jun 2023

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Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

for Emotional Distress

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07143357·Recruiting·Listed Aug 2025

Apply to this trial

Building Connections

for Cancer Colorectal

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT07091032·Recruiting·Listed Jul 2025

Apply to this trial

Treating Insomnia in Mild Cognitive Impairment

for Mild Cognitive Impairment (MCI)

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 60+

Code: NCT06687161·Recruiting·Listed Nov 2024

Apply to this trial

Just-in-time Interventions for Reducing Short-term Suicide Risk

for Suicide

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05793541·Recruiting·Listed Mar 2023

Apply to this trial

Online Parent Education for Child Anxiety

for Anxiety Disorders

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07153250·Recruiting·Listed Sep 2025

Apply to this trial

Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.

for Post Traumatic Stress Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07079761·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

Mechanisms Underlying Efficacy of Prolonged Exposure

for Post Traumatic Stress Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05788302·Recruiting·Listed Mar 2023

Apply to this trial

Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05523817·Recruiting·Listed Aug 2022

Apply to this trial

Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT05570812·Phase 2·Recruiting·Listed Oct 2022

Apply to this trial

Brain Connectivity in Depression

for Depression

2 locations in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT03276793·Recruiting·Listed Sep 2017

Apply to this trial

Accelerated TMS for Perinatal Depression

for Perinatal Depression

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 18 - 55

Code: NCT06968390·Recruiting·Listed May 2025

Apply to this trial

Mechanisms Underlying the Efficacy of Prolonged Exposure

for Posttraumatic Stress Disorder

1 location in Boston

Sponsor: VA Boston Healthcare System

Sex: All·Age: 18 - 90

Code: NCT05663151·Recruiting·Listed Dec 2022

Apply to this trial

Cannabidiol for Reduction of Brain Neuroinflammation

for Back Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT05066308·Phase 2·Recruiting·Listed Oct 2021

Apply to this trial

Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33

for Major Depressive Disorder

Sites in Boston +2 more locations

Sponsor: NYU Langone Health

Sex: All·Age: 18 - 65

Code: NCT05573074·Recruiting·Listed Oct 2022

Apply to this trial

Conditions in Mental health (Boston, MA)

Depression· 52 Anxiety· 18 PTSD (post-traumatic stress disorder)· 16 Schizophrenia· 12 Insomnia· 10 Suicidal ideation / suicide· 9 Obsessive-compulsive disorder (OCD)· 4 Eating disorders· 3 Bipolar disorder· 2 ADHD· 2