Solid tumor Clinical Trials in Boston, MA

As of September 2026, 109 paid clinical trials are recruiting for Solid tumor in Boston, Massachusetts. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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110 clinical trials for Solid tumor

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A Study of DB-1310 in Advanced/Metastatic Solid Tumors

for Advanced Solid Tumor

Sites in Boston +11 more locations

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT05785741·Phase 1, Phase 2·Recruiting·Listed Mar 2023

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Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

for Breast Cancer

Sites in Boston +14 more locations

Sponsor: Incyclix Bio

Sex: All·Age: 18+

Code: NCT05735080·Phase 1, Phase 2·Recruiting·Listed Feb 2023

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A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for Advanced Solid Tumors With KRAS G12C Mutations

Drug: FMC-376

Sites in Boston +11 more locations

Sponsor: Frontier Medicines Corporation

Sex: All·Age: 18+

Code: NCT06244771·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

for Non Small Cell Lung Cancer

Sites in Boston +14 more locations

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06810544·Phase 1, Phase 2·Recruiting·Listed Feb 2025

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A Study of YL201 in Patients With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Boston +18 more locations

Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All·Age: 18+

Code: NCT05434234·Phase 1, Phase 2·Recruiting·Listed Jun 2022

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The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

for Solid Tumors

Sites in Boston +14 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT05203172·Phase 4·Recruiting·Listed Jan 2022

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A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)

for Locally Advanced Solid Tumor

Sites in Boston +16 more locations

Sponsor: Nuvalent Inc.

Sex: All·Age: 18+

Code: NCT06521554·Phase 1·Recruiting·Listed Jul 2024

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A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors

for Solid Tumor, Adult

Sites in Boston +9 more locations

Sponsor: Corbus Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06265727·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

for Solid Tumors

Sites in Boston +16 more locations

Sponsor: ORIC Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05315700·Phase 1, Phase 2·Recruiting·Listed Apr 2022

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A Study of CUSP06 in Patients With Platinum-Refractory/Resistant Ovarian Cancer and Other Advanced Solid Tumors

for Ovarian Cancer

Sites in Boston +13 more locations

Sponsor: OnCusp Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06234423·Phase 1·Recruiting·Listed Jan 2024

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Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

for Solid Tumor

Drug: Givastomig

Sites in Boston +5 more locations

Sponsor: I-Mab Biopharma US Limited

Sex: All·Age: 18+

Code: NCT04900818·Phase 1·Recruiting·Listed May 2021

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First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

for PIK3CA Mutation

Sites in Boston +22 more locations

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05216432·Phase 1·Recruiting·Listed Jan 2022

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A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

for Locally Advanced Solid Tumor

Sites in Boston +18 more locations

Sponsor: Nuvalent Inc.

Sex: All·Age: 12+

Code: NCT05118789·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

for Solid Tumor, Adult

Sites in Boston +12 more locations

Sponsor: GV20 Therapeutics

Sex: All·Age: 18+

Code: NCT05669430·Phase 1, Phase 2·Recruiting·Listed Dec 2022

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A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

for Low-grade Glioma

Sites in Boston +11 more locations

Sponsor: Day One Biopharmaceuticals, Inc.

Sex: All·Age: 6 Months - 25

Code: NCT04775485·Phase 2·Recruiting·Listed Mar 2021

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A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

for Advanced Solid Tumor

Sites in Boston +9 more locations

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT07629960·Phase 1, Phase 2·Recruiting·Listed Jun 2026

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Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

for Non-small Cell Lung Cancer (NSCLC)

Sites in Boston +8 more locations

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT07349537·Phase 1·Recruiting·Listed Jan 2026

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A Study of OTP-01, a Dual Paratopic PD-1/VEGFR2 Antibody, in Patients With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +4 more locations

Sponsor: Ottimo Pharma Limited

Sex: All·Age: 18+

Code: NCT07266428·Phase 1, Phase 2·Recruiting·Listed Dec 2025

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Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)

for Solid Tumor

Drug: Givastomig

Sites in Boston +2 more locations

Sponsor: I-Mab Biopharma US Limited

Sex: All·Age: 18+

Code: NCT07432295·Phase 2·Recruiting·Listed Feb 2026

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A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Boston +6 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT07226349·Phase 1·Recruiting·Listed Nov 2025

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Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

for Metastatic Hepatocellular Carcinoma

Sites in Boston +7 more locations

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT06915753·Phase 1·Recruiting·Listed Apr 2025

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A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

for Colorectal Cancer

Sites in Boston +4 more locations

Sponsor: PAQ Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07300150·Phase 1·Recruiting·Listed Dec 2025

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STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas

for Solid Tumor

Sites in Boston +9 more locations

Sponsor: STORM Therapeutics LTD

Sex: All·Age: 18+

Code: NCT06975293·Phase 1, Phase 2·Recruiting·Listed May 2025

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Phase 1 Study of Intratumoral Administration of VAX014 With Expansion in Combination With a Checkpoint Inhibitor in Subjects With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Boston +7 more locations

Sponsor: Vaxiion Therapeutics

Sex: All·Age: 18+

Code: NCT05901285·Phase 1·Recruiting·Listed Jun 2023

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First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors

for Solid Tumors

Sites in Boston +2 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06644755·Phase 1·Recruiting·Listed Oct 2024

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ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours

for Advanced Solid Tumor

Sites in Boston +6 more locations

Sponsor: Adcendo ApS

Sex: All·Age: 18+

Code: NCT06597721·Phase 1·Recruiting·Listed Sep 2024

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Study of GS-5319 Given Alone or in Combination in Adults With Solid Tumors

for Advanced Solid Tumor

Drug: GS-5319

Sites in Boston +3 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT07128303·Phase 1·Recruiting·Listed Aug 2025

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Anti-GD2 ADC M3554 in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Boston +1 more location

Sponsor: EMD Serono Research & Development Institute, Inc.

Sex: All·Age: 18+

Code: NCT06641908·Phase 1·Recruiting·Listed Oct 2024

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A Study of PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors

for Solid Tumor

Drug: PT0253

Sites in Boston +6 more locations

Sponsor: PAQ Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06797336·Phase 1·Recruiting·Listed Jan 2025

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First In Human Study of CX-2051 in Advanced Solid Tumors

for Solid Tumor, Adult

Sites in Boston +7 more locations

Sponsor: CytomX Therapeutics

Sex: All·Age: 18+

Code: NCT06265688·Phase 1·Recruiting·Listed Feb 2024

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Study in Advanced Solid Tumor Patients

for Advanced Solid Tumor

Sites in Boston +4 more locations

Sponsor: Callio Therapeutics

Sex: All·Age: 18+

Code: NCT07300943·Phase 1, Phase 2·Recruiting·Listed Dec 2025

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Study of GS-0201 Alone and in Combination in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +4 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06167317·Phase 1·Recruiting·Listed Dec 2023

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A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

for Advanced Solid Tumors

Sites in Boston +5 more locations

Sponsor: SEED Therapeutics, Inc.

Sex: All·Age: 16+

Code: NCT07197554·Phase 1·Recruiting·Listed Sep 2025

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A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

for Melanoma

Sites in Boston +6 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 6 Months - 17

Code: NCT02332668·Phase 1, Phase 2·Recruiting·Listed Jan 2015

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Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

for Advanced Solid Tumor

Drug: CX-5461

Sites in Boston +4 more locations

Sponsor: Senhwa Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT04890613·Phase 1·Recruiting·Listed May 2021

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A Study of MGC028 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +6 more locations

Sponsor: MacroGenics

Sex: All·Age: 18+

Code: NCT06723236·Phase 1·Recruiting·Listed Dec 2024

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Study of GS-2121 Given Alone or in Combination in Adults With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +3 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06532565·Phase 1·Recruiting·Listed Aug 2024

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Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

for Solid Tumor, Adult

Sites in Boston +8 more locations

Sponsor: Vivace Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT04665206·Phase 1, Phase 2·Recruiting·Listed Dec 2020

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SNV4818 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +4 more locations

Sponsor: Pikavation Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06736704·Phase 1, Phase 2·Recruiting·Listed Dec 2024

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Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Boston +3 more locations

Sponsor: Ankyra Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06171750·Phase 1·Recruiting·Listed Dec 2023

Apply to this trial