Clinical Trials at Brigham and Women's Hospital

As of July 2026, 297 paid clinical trials are recruiting at Brigham and Women's Hospital, located at 75 FRANCIS ST, BOSTON, MA 02115-6110, phone (617) 525-7104 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 19, 2026.

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299 clinical trials at Brigham and Women's Hospital

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A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis

for Familial Pulmonary Fibrosis

Drug: Nerandomilast

Sites in Boston +12 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 40+

Code: NCT07201922·Phase 3·Recruiting·Listed Oct 2025

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REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults

for Venous Thromboembolism (VTE)

Sites in Boston +19 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07015905·Phase 3·Recruiting·Listed Jun 2025

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Assessment of Support With Impella® Best Practices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

for AMI Cardiogenic Shock

Sites in Boston +17 more locations

Sponsor: Abiomed Inc.

Sex: All·Age: 18+

Code: NCT06964685·Recruiting·Listed May 2025

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A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum

for Pyoderma Gangrenosum

Sites in Boston +20 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06624670·Phase 3·Recruiting·Listed Oct 2024

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(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

for Indolent Systemic Mastocytosis

Sites in Boston +13 more locations

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT04910685·Phase 2, Phase 3·Recruiting·Listed Jun 2021

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A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

for Advanced/Metastatic Solid Tumors

Sites in Boston, Newton +19 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07090499·Phase 1·Recruiting·Listed Jul 2025

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A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)

for Pemphigus Vulgaris

Sites in Boston +9 more locations

Sponsor: Cabaletta Bio

Sex: All·Age: 18+

Code: NCT04422912·Phase 1, Phase 2·Recruiting·Listed Jun 2020

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Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

for Lower Respiratory Tract Infection

Sites in Boston +18 more locations

Sponsor: Ansun Biopharma, Inc.

Sex: All·Age: All ages

Code: NCT03808922·Phase 3·Recruiting·Listed Jan 2019

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A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic

for Rheumatoid Arthritis (RA)

Sites in Boston +9 more locations

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 71

Code: NCT07123038·Recruiting·Listed Aug 2025

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PUL-042 Treatment in Patients With Parainfluenza Virus (PIV), Human Metapneumovirus (hMPV) or Respiratory Syncytial Virus (RSV)

for Hematologic Malignancies

Sites in Boston +10 more locations

Sponsor: Pulmotect, Inc.

Sex: All·Age: 18+

Code: NCT06665100·Phase 2·Recruiting·Listed Oct 2024

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RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

for Systemic Lupus Erythematosus

Sites in Boston, Worcester +17 more locations

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 65

Code: NCT06121297·Phase 1, Phase 2·Recruiting·Listed Nov 2023

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Cryoablation for Monomorphic Ventricular Tachycardia

for Sustained VT

Sites in Boston +12 more locations

Sponsor: Adagio Medical

Sex: All·Age: 18+

Code: NCT05675865·Recruiting·Listed Jan 2023

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A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

for Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

Sites in Boston +17 more locations

Sponsor: MeiraGTx, LLC

Sex: All·Age: 18+

Code: NCT05926765·Phase 2·Recruiting·Listed Jul 2023

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A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer

for Non-muscle-invasive Bladder Cancer

Sites in Boston +18 more locations

Sponsor: SURGE Therapeutics

Sex: All·Age: 18+

Code: NCT05710848·Phase 1, Phase 2·Recruiting·Listed Feb 2023

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Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System

for Pulmonary Arterial Hypertension

Sites in Boston +8 more locations

Sponsor: Aria CV, Inc

Sex: All·Age: 18+

Code: NCT04555161·Recruiting·Listed Sep 2020

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An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

for Mitral Regurgitation

Sites in Boston +7 more locations

Sponsor: HighLife SAS

Sex: All·Age: 18+

Code: NCT04029337·Recruiting·Listed Jul 2019

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A Study of LY4005130 in Adult Participants With Severe Alopecia Areata (Hair Loss)

for Alopecia Areata

Drug: LY4005130

Sites in Boston +8 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 50

Code: NCT07533006·Phase 2·Recruiting·Listed Apr 2026

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A Study of CDX-622 in Participants With Mild to Moderate Asthma

for Mild to Moderate Asthma

Sites in Boston +3 more locations

Sponsor: Celldex Therapeutics

Sex: All·Age: 18+

Code: NCT07330778·Phase 1·Recruiting·Listed Jan 2026

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FIBERGRAFT Aeridyan Posterolateral Fusion Study

for Degenerative Spine Disease

Sites in Boston +7 more locations

Sponsor: DePuy Synthes Products, Inc.

Sex: All·Age: 18+

Code: NCT07059065·Recruiting·Listed Jul 2025

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Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding

for Acute Gastrointestinal Bleeding

Sites in Boston +5 more locations

Sponsor: Medtronic - MITG

Sex: All·Age: 22+

Code: NCT06188585·Recruiting·Listed Jan 2024

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LAM-001 for the Treatment of Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

for Pulmonary Hypertension Due to Lung Diseases and Hypoxia

Sites in Boston +2 more locations

Sponsor: OrphAI Therapeutics

Sex: All·Age: 18 - 80

Code: NCT05798923·Phase 2·Recruiting·Listed Apr 2023

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Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

for Rheumatoid Arthritis

Sites in Boston +8 more locations

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT06201416·Phase 1·Recruiting·Listed Jan 2024

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A Phase 2a Study of Foralumab Nasal in Patients With Multiple System Atrophy (MSA)

for Multiple System Atrophy

Drug: Foralumab

1 location in Boston

Sponsor: Tiziana Life Sciences LTD

Sex: All·Age: 30 - 85

Code: NCT06868628·Phase 2·Recruiting·Listed Mar 2025

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Post Market Study for VasQ, an External Support Implant for Arteriovenous Fistula

for End Stage Renal Disease

Sites in Boston +7 more locations

Sponsor: Laminate Medical Technologies

Sex: All·Age: 18 - 80

Code: NCT06516653·Recruiting·Listed Jul 2024

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A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

for Drug Resistant Epilepsy

Sites in Boston +2 more locations

Sponsor: NaviFUS Corporation

Sex: All·Age: 18+

Code: NCT06388707·Phase 1, Phase 2·Recruiting·Listed Apr 2024

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Microbial Cell-free Metagenomic Sequencing for Suspected Infections in Adult Immunocompromised Outpatients

for Infection

Sites in Boston +5 more locations

Sponsor: Karius, Inc.

Sex: All·Age: 18+

Code: NCT07110636·Recruiting·Listed Aug 2025

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A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Thalamotomy for the Treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's Disease

for Tremor Associated With Tremor Dominant Parkinson's Disease

Sites in Boston +6 more locations

Sponsor: InSightec

Sex: All·Age: 30 - 99

Code: NCT04991831·Recruiting·Listed Aug 2021

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US Benchmarking Clinical Study

for HFpEF - Heart Failure With Preserved Ejection Fraction

3 locations in Boston

Sponsor: eMyosound SAS

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07215715·Recruiting·Listed Oct 2025

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Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults

for Healthy Adults

1 location in Boston

Sponsor: Metro International Biotech, LLC

Sex: All·Age: 19 - 60·Accepts healthy volunteers

Code: NCT06815991·Phase 1·Recruiting·Listed Feb 2025

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CraniSeal Post Approval Study

for Leak, Cerebrospinal Fluid

Sites in Boston +6 more locations

Sponsor: Pramand LLC

Sex: All·Age: 18+

Code: NCT06406790·Phase 4·Recruiting·Listed May 2024

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Endovascular Repair With Fenestrated TREO Stent-Graft System in AAA

for Abdominal Aortic Aneurysms (AAA)

Sites in Boston +4 more locations

Sponsor: Bolton Medical

Sex: All·Age: 18+

Code: NCT07026877·Recruiting·Listed Jun 2025

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Access Cannulation Trial II

for Dialysis

Sites in Boston +7 more locations

Sponsor: Voyager Biomedical

Sex: All·Age: 18+

Code: NCT05490225·Recruiting·Listed Aug 2022

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Endoscopic Ultrasound Shear Wave Elastography Study

for MASLD

Sites in Boston +1 more location

Sponsor: Olympus Corporation of the Americas

Sex: All·Age: 18+

Code: NCT06592820·Recruiting·Listed Sep 2024

Apply to this trial

Apple Health Study

for Mental Health

Sites in Boston +1 more location

Sponsor: Apple Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06958523·Recruiting·Listed May 2025

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Tracing the Metabolic Flux of Orally Administered NAD+ Precursors

for Healthy Adults

1 location in Boston

Sponsor: Metro International Biotech, LLC

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06882096·Phase 1·Recruiting·Listed Mar 2025

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Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial

for Critical Illness

1 location in Boston

Sponsor: Wandercraft

Sex: All·Age: 18+

Code: NCT07220733·Phase 1, Phase 2·Recruiting·Listed Oct 2025

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Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

for Arrhythmogenic Right Ventricular Cardiomyopathy

Sites in Boston +7 more locations

Sponsor: Tenaya Therapeutics

Sex: All·Age: 14 - 65

Code: NCT06311708·Recruiting·Listed Mar 2024

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A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy

for Multiple System Atrophy

Sites in Boston +5 more locations

Sponsor: Dasher Neuroscience Inc.

Sex: All·Age: 30+

Code: NCT06848231·Phase 2·Recruiting·Listed Feb 2025

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Feasibility Study Evaluating the Safety and Effectiveness of Magnetic Bead Tracking System When Used With a Bionic External Prosthesis

for Transtibial Amputee

1 location in Boston

Sponsor: MuscleMetrix, LLC

Sex: All·Age: 22 - 65

Code: NCT07195461·EARLY_Phase 1·Recruiting·Listed Sep 2025

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Exploratory Clinical Study to Assess Safety and Efficacy of Xenon Gas Inhalation to Control Neuroinflammation

for Healthy Volunteer Study

1 location in Boston

Sponsor: General Biophysics LLC

Sex: All·Age: 55 - 75·Accepts healthy volunteers

Code: NCT06945614·Phase 1·Recruiting·Listed Apr 2025

Apply to this trial