Clinical Trials at Brigham and Women's Hospital

As of June 2026, 359 paid clinical trials are recruiting at Brigham and Women's Hospital in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

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359 clinical trials at Brigham and Women's Hospital

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AGENT DCB STANCE: Safety and Effectiveness Study of AGENT Drug-Coated Balloon Compared to Standard of Care Percutaneous Coronary Intervention (PCI) Treatment for de Novo Coronary Lesions

for Coronary Arterial Disease (CAD)

38 locations incl. La Jolla

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT06959524·Recruiting

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A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

for Advanced/Metastatic Solid Tumors

21 locations incl. Duarte

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07090499·Phase 1·Recruiting

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Accelerated TMS for Perinatal Depression

for Perinatal Depression

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 18 - 55

Code: NCT06968390·Recruiting

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CUE-102 in Recurrent Glioblastoma

for Recurrent Glioblastoma

2 locations incl. Boston

Sponsor: David Reardon, MD

Sex: All·Age: 18+

Code: NCT06917885·Phase 1·Recruiting

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Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

for Pulmonary Hypertension

25 locations incl. Birmingham

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06911632·Recruiting

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A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic

for Rheumatoid Arthritis (RA)

10 locations incl. San Francisco

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 71

Code: NCT07123038·Recruiting

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Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy

for Recurrent Non-Muscle Invasive Bladder Carcinoma

56 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07000084·Phase 3·Recruiting

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Early Vedolizumab as First-Line for Immune-Related Colitis Therapy Trial

for Immune Checkpoint Inhibitor-Related Colitis

2 locations incl. Boston

Sponsor: Shilpa Grover, MD, MPH

Sex: All·Age: 18+

Code: NCT06841705·Phase 2·Recruiting

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A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

for COVID-19 Infection

60 locations incl. Canoga Park

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07013474·Phase 3·Recruiting

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H. Pylori Eradication With Argon Plasma During Endoscopy

for Helicobacter Pylori Infection

1 location in Boston

Sponsor: Christopher C. Thompson, MD, MSc

Sex: All·Age: 18+

Code: NCT06529159·Recruiting

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RCT of Home-based vs Formal Physical Therapy for Treatment of New Onset Non-insertional Achilles Tendinopathy

for Achilles Tendinopathy

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06374654·Enrolling By Invitation

PUL-042 Treatment in Patients With Parainfluenza Virus (PIV), Human Metapneumovirus (hMPV) or Respiratory Syncytial Virus (RSV)

for Hematologic Malignancies

11 locations incl. Duarte

Sponsor: Pulmotect, Inc.

Sex: All·Age: 18+

Code: NCT06665100·Phase 2·Recruiting

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The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

for Ischemic Heart Disease (IHD)

11 locations incl. San Francisco

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 35 - 85

Code: NCT06854458·Recruiting

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Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study

for Moderate Aortic Valve Stenosis

Drug: Ataciguat

66 locations incl. Birmingham

Sponsor: Kardigan, Inc.

Sex: All·Age: 50+

Code: NCT07001800·Phase 2, Phase 3·Recruiting

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REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults

for Venous Thromboembolism (VTE)

19 locations incl. Sheffield

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07015905·Phase 3·Recruiting

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Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

for Obesity

2 locations incl. Boston

Sponsor: Pichamol Jirapinyo, MD, MPH

Sex: All·Age: 18+

Code: NCT06138821·Recruiting

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Cocoa Extract for Migraine Trial

for Migraine

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06808230·Recruiting

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Evaluating Informatics-assisted Immune-related Adverse Event Detection to Improve Registration Onto a Biorepository

for Malignancy

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: All ages

Code: NCT06789601·Phase 1, Phase 2·Recruiting

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Toripalimab With Chemotherapy for Sinus Cancer

for Sinonasal Cancer

2 locations incl. Boston

Sponsor: Glenn J. Hanna

Sex: All·Age: 18+

Code: NCT06940180·Phase 2·Recruiting

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Semaglutide for Helping Opioid Recovery

for Opioid Use Disorder

Drug: Semaglutide

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06639464·Phase 2·Recruiting

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Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy

for Postoperative Pain

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06483659·Phase 2·Recruiting

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Assessment of Circuit Rebreathing During CPAP Therapy

for Obstructive Sleep Apnea (OSA)

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 70

Code: NCT07062770·Recruiting

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Practical Geriatric Assessment in Older Adults With Non-Small Cell Lung Cancer Undergoing Stereotactic Body Radiation Therapy

for Lung Cancer (NSCLC)

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 65+

Code: NCT06987890·Recruiting

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The Impact of Music Medicine on Preterm Brain Development and Behavior

for Infant Development

2 locations incl. New Haven

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 24 Weeks - 30 Weeks

Code: NCT06536296·Recruiting

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A Phase 2a Study of Foralumab Nasal in Patients With Multiple System Atrophy (MSA)

for Multiple System Atrophy

Drug: Foralumab

1 location in Boston

Sponsor: Tiziana Life Sciences LTD

Sex: All·Age: 30 - 85

Code: NCT06868628·Phase 2·Recruiting

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Assessment of Synaptic Density in MS

for Multiple Sclerosis

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT04634994·EARLY_Phase 1·Recruiting

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PARADIGM - En Bloc Trial With the EndoQuest Endoluminal Surgical (ELS) System

for Colorectal Lesion

6 locations incl. Scottsdale

Sponsor: EndoQuest Robotics, Inc.

Sex: All·Age: 22+

Code: NCT06133387·Recruiting

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Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

for Amyloidosis

Drug: Acoramidis

39 locations incl. La Jolla

Sponsor: Eidos Therapeutics, a BridgeBio company

Sex: All·Age: 18 - 75

Code: NCT06563895·Phase 3·Recruiting

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A Study to Learn About the Effects of Felzartamab Infusions on Adults With Immunoglobulin A Nephropathy (IgAN)

for Immunoglobulin A Nephropathy (IgAN)

28 locations incl. Little Rock

Sponsor: Biogen

Sex: All·Age: 18+

Code: NCT06935357·Phase 3·Recruiting

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Tracing the Metabolic Flux of Orally Administered NAD+ Precursors

for Healthy Adults

1 location in Boston

Sponsor: Metro International Biotech, LLC

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06882096·Phase 1·Recruiting

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Access Cannulation Trial II

for Dialysis

8 locations incl. Dothan

Sponsor: Voyager Biomedical

Sex: All·Age: 18+

Code: NCT05490225·Recruiting

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BRAZAN: A Randomized Phase 2 Study of Bendamustine, Rituximab, Cytarabine (AraC) Induction With Zanubrutinib (BRAZAN) Followed by Zanubrutinib/Rituximab +/- Sonrotoclax Maintenance in Treatment-Naïve Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Drug: Sonrotoclax

7 locations incl. Phoenix

Sponsor: Christine Ryan

Sex: All·Age: 18+

Code: NCT06854003·Phase 2·Recruiting

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Exploratory Clinical Study to Assess Safety and Efficacy of Xenon Gas Inhalation to Control Neuroinflammation

for Healthy Volunteer Study

1 location in Boston

Sponsor: General Biophysics LLC

Sex: All·Age: 55 - 75·Accepts healthy volunteers

Code: NCT06945614·Phase 1·Recruiting

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Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial

for Glioblastoma (GBM)

3 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 65+

Code: NCT06835803·Phase 2·Recruiting

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Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS

for Unstable Blood Pressure

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 24 Weeks - 44 Weeks

Code: NCT06994494·Recruiting

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FORWARD CAD IDE Study

for Coronary Arterial Disease (CAD)

28 locations incl. La Jolla

Sponsor: Shockwave Medical, Inc.

Sex: All·Age: 18+

Code: NCT06662500·Recruiting

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Computerized Decision Support for Identification and Management of Familial Hypercholesterolemia

for Familial Hypercholesterolaemia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: All ages

Code: NCT06743659·Recruiting

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A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohns Disease

Drug: Afimkibart

92 locations incl. Dothan

Sponsor: Hoffmann-La Roche

Sex: All·Age: 16 - 80

Code: NCT06819878·Phase 3·Recruiting

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Alleviant ALLAY-HFrEF Study

for Heart Failure

32 locations incl. Los Angeles

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 18+

Code: NCT06812533·Enrolling By Invitation

Azenosertib in Uterine Serous Carcinoma: Biomarker Study

for Uterine Serous Carcinoma

2 locations incl. Boston

Sponsor: Joyce Liu, MD

Sex: Female·Age: 18+

Code: NCT06369155·Phase 2·Recruiting

Apply to this trial