Clinical Trials at Brigham and Women's Hospital

As of June 2026, 359 paid clinical trials are recruiting at Brigham and Women's Hospital in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

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359 clinical trials at Brigham and Women's Hospital

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Alzheimer's Disease Neuroimaging Initiative 4

for Mild Cognitive Impairment

59 locations incl. Birmingham

Sponsor: University of Southern California

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05617014·Enrolling By Invitation

From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects

for Chronic Pain

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT05661903·Phase 2·Recruiting

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Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC

for Head and Neck Squamous Cell Carcinoma

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05726370·Phase 2·Recruiting

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A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]

for Myositis

47 locations incl. Glendale

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT05895786·Phase 3·Recruiting

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LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

for Angina

10 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 65+

Code: NCT05786417·Phase 4·Recruiting

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TRUDI: TDXD+Durva in HER2+/Low IBC

for Invasive Breast Cancer

3 locations incl. Boston

Sponsor: Filipa Lynce, MD

Sex: Female·Age: 18+

Code: NCT05795101·Phase 2·Recruiting

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An Open-label Study of XEN1101 in Epilepsy

for Focal Epilepsy

53 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT05718817·Phase 3·Enrolling By Invitation

NAD Augmentation in Diabetes Kidney Disease

for Type2diabetes

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 30+

Code: NCT05759468·Phase 2·Recruiting

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Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer

for Prostate Cancer

5 locations incl. Duarte

Sponsor: Varian, a Siemens Healthineers Company

Sex: Male·Age: 18+

Code: NCT05804318·Recruiting

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MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI

for Mesothelioma

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05730816·Phase 2·Recruiting

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Dietary Intervention to Mitigate Adverse Consequences of Night Work

for Dietary Habits

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT04868526·Recruiting

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The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease

for Chronic Kidney Disease

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07222683·Recruiting

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Shingrix in Renal Transplant Recipients

for Kidney Transplant Recipient Response to Shingrix Vaccine

4 locations incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 70

Code: NCT04128189·Phase 3·Recruiting

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Patient-Centered Surgical Prehabilitation

for Bladder Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT05715684·Recruiting

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Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy

for Peripheral Artery Disease

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06300450·Recruiting

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VS-6766+Abema+Fulv in Met HR+/HER- BC

for Breast Cancer

3 locations incl. Boston

Sponsor: Adrienne G. Waks

Sex: All·Age: 18+

Code: NCT05608252·Phase 1, Phase 2·Recruiting

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Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

for Metastatic Renal Cell Carcinoma

313 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05327686·Phase 2·Recruiting

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Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

for Arrhythmogenic Right Ventricular Cardiomyopathy

8 locations incl. San Francisco

Sponsor: Tenaya Therapeutics

Sex: All·Age: 14 - 65

Code: NCT06311708·Recruiting

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Alleviant ALLAY-HF Study

for Heart Failure

53 locations incl. Birmingham

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Enrolling By Invitation

Three-dimensional (3D) Printed Hemodialysis Vascular Model

for Hemodialysis Access Failure

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05096416·Not Yet Recruiting

Biology of Young Lung Cancer Study: The YOUNG LUNG Study

for Non Small Cell Lung Cancer

4 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 15+

Code: NCT05265429·Recruiting

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Testing Effects of Melatonin on Uterine Contractions in Women

for Pregnant Women

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 18 - 35·Accepts healthy volunteers

Code: NCT05358834·Recruiting

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Investigating Hereditary Risk In Thoracic Cancers (INHERIT)

for Lung Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05587439·Recruiting

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Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study

for Primary Aldosteronism

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 85

Code: NCT05030545·Phase 4·Recruiting

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A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

for Melanoma

58 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 16+

Code: NCT05538130·Phase 1·Recruiting

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An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

for Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

46 locations incl. Scottsdale

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05667493·Phase 3·Enrolling By Invitation

Microdevice In Ovarian, Fallopian Tube, And Peritoneal Cancer

for Ovarian Cancer

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 18+

Code: NCT04701645·Phase 1·Recruiting

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Menstrual-phase-dependent Differences in Response to Sleep Loss

for Sleep Deprivation

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 18 - 35·Accepts healthy volunteers

Code: NCT05381532·Recruiting

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PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes

for Type2Diabetes

36 locations incl. Huntsville

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 40 - 80

Code: NCT05390892·Phase 4·Recruiting

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Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease

for Idiopathic Pulmonary Fibrosis

86 locations incl. Birmingham

Sponsor: United Therapeutics

Sex: All·Age: 40+

Code: NCT04905693·Phase 3·Enrolling By Invitation

Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

for Peripartum Cardiomyopathy, Postpartum

64 locations incl. Birmingham

Sponsor: Dennis M. McNamara, MD, MS

Sex: Female·Age: 18+

Code: NCT05180773·Phase 4·Recruiting

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Pre-emptive Prevention for Patients at High Risk for Hospital-onset Clostridioides Difficile

for C. Difficile

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05389904·Recruiting

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Endoscopic Metabolic and Bariatric Therapies

for Obesity

1 location in Boston

Sponsor: Christopher C. Thompson, MD, MSc

Sex: All·Age: 18 - 80

Code: NCT05725967·Enrolling By Invitation

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

for Melanoma

31 locations incl. Fayetteville

Sponsor: Pfizer

Sex: All·Age: 16+

Code: NCT05355701·Phase 1·Recruiting

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Abatacept in Immune Checkpoint Inhibitor Myocarditis

for Myocarditis Acute

29 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05335928·Phase 3·Recruiting

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Testing Tumor Tissue and Blood to Help Select Personalized Treatments for Patients With Suspected Lung Cancers

for NSCLC

21 locations incl. Davis

Sponsor: Lung Cancer Mutation Consortium

Sex: All·Age: All ages

Code: NCT04712877·Recruiting

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Intraoral Photobiomodulation Therapy to Prevent Oral Mucositis in Patients Undergoing Hematopoietic Cell Transplantation

for Myeloablative Allogeneic Hematopoietic Cell Transplantation

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05335434·Recruiting

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Atomoxetine and DAW2022 on OSA Severity

for Obstructive Sleep Apnea

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 70

Code: NCT05350215·Phase 1, Phase 2·Recruiting

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A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Thalamotomy for the Treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's Disease

for Tremor Associated With Tremor Dominant Parkinson's Disease

7 locations incl. Miami

Sponsor: InSightec

Sex: All·Age: 30 - 99

Code: NCT04991831·Recruiting

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Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial

for Graft Vs Host Disease

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05236062·Recruiting

Apply to this trial