Clinical Trials at Brigham and Women's Hospital

As of June 2026, 359 paid clinical trials are recruiting at Brigham and Women's Hospital in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

Filter results

Filter results

State

City

Facility

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

359 clinical trials at Brigham and Women's Hospital

·Clear filters·↓ Download CSV

Pictographs for Preventing Wrong-Patient Errors in NICUs

for Medical Errors

4 locations incl. Baltimore

Sponsor: Columbia University

Sex: All·Age: All ages

Code: NCT03960099·Recruiting

Apply to this trial

The Impact of Pcsk-9 Inhibition on PET CFR in Patients at High CV Risk

for Stable Coronary Disease

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 50 - 90

Code: NCT05152888·Phase 4·Recruiting

Apply to this trial

Multi-Center PAMPA Study

for Psoriasis

3 locations incl. Boston

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT05004727·Phase 4·Recruiting

Apply to this trial

Real-time Symptom Monitoring Using ePROs to Prevent Adverse Events During Care Transitions

for Multiple Chronic Conditions

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05282654·Recruiting

Apply to this trial

Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism

for Opioid Use

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 18+

Code: NCT04798469·Phase 2·Recruiting

Apply to this trial

Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II

for Refractory Angina

70 locations incl. Phoenix

Sponsor: Shockwave Medical, Inc.

Sex: All·Age: 18+

Code: NCT05102019·Recruiting

Apply to this trial

Stereotactic Body Radiotherapy (SBRT) for Early Treatment of Oligometastatic Adenoid Cystic Carcinoma: The SOLAR Trial

for Adenoid Cystic Carcinoma

5 locations incl. San Francisco

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04883671·Recruiting

Apply to this trial

(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

for Indolent Systemic Mastocytosis

14 locations incl. Birmingham

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT04910685·Phase 2, Phase 3·Recruiting

Apply to this trial

Anti-Inflammatory Treatment of Uremic Cardiomyopathy With Colchicine

for Chronic Kidney Diseases

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 80

Code: NCT04500665·Phase 2·Recruiting

Apply to this trial

Scalp Cooling in MBC

for Metastatic Breast Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04986579·Phase 2·Recruiting

Apply to this trial

Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

for Atrial Fibrillation

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 20 - 90

Code: NCT04880265·Recruiting

Apply to this trial

Geriatric Thoracic Surgery Ambulation Challenge

for Thoracic Diseases

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 65+

Code: NCT04630496·Recruiting

Apply to this trial

Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial Neoplasia

for Endometrial Carcinoma

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18+

Code: NCT04839614·Recruiting

Apply to this trial

Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18+

Code: NCT04724499·Recruiting

Apply to this trial

Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

for HPV-Associated Oropharyngeal Squamous Cell Carcinoma

2 locations incl. Boston

Sponsor: Jonathan Schoenfeld, MD, MPH

Sex: All·Age: 22+

Code: NCT04900623·Phase 2·Recruiting

Apply to this trial

Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting

for Coronary Artery Disease

40 locations incl. Birmingham

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT04451044·Enrolling By Invitation

Paxalisib (GDC-0084) In Recurrent Or Refractory PCNSL

for Primary Central Nervous System Lymphoma

2 locations incl. Boston

Sponsor: Lakshmi Nayak, MD

Sex: All·Age: 18+

Code: NCT04906096·Phase 2·Recruiting

Apply to this trial

Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease

for Non-Alcoholic Fatty Liver Disease

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05728697·Recruiting

Apply to this trial

Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer

for Non-small Cell Lung Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04789486·Phase 1, Phase 2·Recruiting

Apply to this trial

Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

for Symptomatic Hypertrophic Cardiomyopathy (HCM)

Drug: Aficamten

52 locations incl. Birmingham

Sponsor: Cytokinetics

Sex: All·Age: 18 - 85

Code: NCT04848506·Phase 2, Phase 3·Enrolling By Invitation

LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

for Superficial Bladder Cancer

49 locations incl. Birmingham

Sponsor: enGene, Inc.

Sex: All·Age: 18+

Code: NCT04752722·Phase 1, Phase 2·Recruiting

Apply to this trial

Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System

for Pulmonary Arterial Hypertension

12 locations incl. La Jolla

Sponsor: Aria CV, Inc

Sex: All·Age: 18+

Code: NCT04555161·Recruiting

Apply to this trial

Low Dose IL-2 for the Treatment of Crohn's Disease

for Crohn Disease

3 locations incl. Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 12 - 80

Code: NCT04263831·Phase 1, Phase 2·Recruiting

Apply to this trial

The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

for Mitral Annular Calcification

16 locations incl. Gilbert

Sponsor: Mayra Guerrero

Sex: All·Age: 18+

Code: NCT04408430·Recruiting

Apply to this trial

Genetic Epidemiology of Rotator Cuff Tears: The cuffGEN Study

for Rotator Cuff Tears

10 locations incl. Iowa City

Sponsor: University of Michigan

Sex: All·Age: 40 - 85

Code: NCT04831164·Recruiting

Apply to this trial

Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen Deficiency

for Hypogonadism, Male

3 locations incl. Augusta

Sponsor: Seattle Institute for Biomedical and Clinical Research

Sex: Male·Age: 55+

Code: NCT04301765·Phase 2·Recruiting

Apply to this trial

Defibrotide for the Treatment of Severe COVID-19

for Covid19

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT04652115·Phase 2·Recruiting

Apply to this trial

Post-op T-DM1 in HER-2+ Salivary Gland Carcinomas

for Salivary Gland Cancer

13 locations incl. Atlanta

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04620187·Phase 2·Recruiting

Apply to this trial

CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

for Mitral Regurgitation

9 locations incl. Tucson

Sponsor: Universitätsklinikum Hamburg-Eppendorf

Sex: All·Age: 18+

Code: NCT04688190·Recruiting

Apply to this trial

A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)

for Pemphigus Vulgaris

13 locations incl. Redwood City

Sponsor: Cabaletta Bio

Sex: All·Age: 18+

Code: NCT04422912·Phase 1, Phase 2·Recruiting

Apply to this trial

Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress

for Li-Fraumeni Syndrome

3 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: All ages

Code: NCT04541654·Recruiting

Apply to this trial

An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

for Mitral Regurgitation

10 locations incl. Tucson

Sponsor: HighLife SAS

Sex: All·Age: 18+

Code: NCT04029337·Recruiting

Apply to this trial

Pilot Study of an Implantable Microdevice for Evaluating Drug Responses in Situ in Prostate Cancer

for Prostate Cancer

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 22+

Code: NCT04399876·Phase 1·Enrolling By Invitation

S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer

for Extensive Stage Lung Small Cell Carcinoma

428 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04155034·Phase 3·Recruiting

Apply to this trial

Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer, INNOVATE Trial

for Prostate Adenocarcinoma

Drug: Apalutamide

345 locations incl. Phoenix

Sponsor: NRG Oncology

Sex: Male·Age: 18+

Code: NCT04134260·Phase 3·Recruiting

Apply to this trial

Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effects

for Malignancy

626 locations incl. Anchorage

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: All ages

Code: NCT04242095·Recruiting

Apply to this trial

Implantable Microdevice In Primary Brain Tumors

for Grade II Glioma

1 location in Boston

Sponsor: Oliver Jonas

Sex: All·Age: 18+

Code: NCT04135807·EARLY_Phase 1·Recruiting

Apply to this trial

AMI Construction in Lower Extremity Residual Limbs

for Amputation

3 locations incl. Bethesda

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT04063592·Recruiting

Apply to this trial

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting

Apply to this trial

RESET System Pivotal Trial (Rev F)

for Diabetes type2

7 locations incl. Washington D.C.

Sponsor: Morphic Medical Inc.

Sex: All·Age: 22 - 65

Code: NCT04101669·Recruiting

Apply to this trial