Clinical Trials at Dana Farber Cancer Institute

As of September 2026, 210 paid clinical trials are recruiting at Dana Farber Cancer Institute, located at 44 BINNEY ST, BOSTON, MA 02115-6013, phone (617) 632-3497 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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211 clinical trials at Dana Farber Cancer Institute

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A Study of Ruxolitinib and Duvelisib in People With Lymphoma

for T-cell Lymphomas

Drug: Ruxolitinib

Sites in Boston +7 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT05010005·Phase 1·Recruiting·Listed Aug 2021

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CB-103 With Either Lenvatinib or Abemaciclib in Patients With NOTCH ACC

for Adenoid Cystic Carcinoma

1 location in Boston

Sponsor: Michael J. Dennis, MD

Sex: All·Age: 18+

Code: NCT05774899·Phase 1, Phase 2·Recruiting·Listed Mar 2023

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Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases

for Brain Tumor

2 locations in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT04033497·Recruiting·Listed Jul 2019

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Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

for Brain Cancer

2 locations in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT04899908·Phase 2·Recruiting·Listed May 2021

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Boston +112 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

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Serial MRI Scans During Radiation Therapy

for Glioblastoma

2 locations in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04188535·Recruiting·Listed Dec 2019

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ETHAN - ET for Male BC

for Male Breast Cancer

Sites in Boston +8 more locations

Sponsor: Jose Pablo Leone

Sex: Male·Age: 18+

Code: NCT05501704·Phase 2·Recruiting·Listed Aug 2022

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A Study of Talazoparib With or Without Enzalutamide in People With Prostate Cancer Who Have Previously Received Abiraterone Acetate or Darolutamide

for Prostate Cancer (Adenocarcinoma)

Sites in Boston +7 more locations

Sponsor: Prostate Cancer Clinical Trials Consortium

Sex: Male·Age: 18+

Code: NCT06844383·Phase 2·Recruiting·Listed Feb 2025

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InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

for Cancer Risk

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05463796·Recruiting·Listed Jul 2022

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PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

for Head and Neck Cancer

2 locations in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06239220·Phase 2·Recruiting·Listed Feb 2024

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On-Trac: An Online Intervention for Cancer Survivors Managing Anxiety

for Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07305740·Recruiting·Listed Dec 2025

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Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

for HPV-Associated Oropharyngeal Squamous Cell Carcinoma

2 locations in Boston

Sponsor: Jonathan Schoenfeld, MD, MPH

Sex: All·Age: 22+

Code: NCT04900623·Phase 2·Recruiting·Listed May 2021

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Sacituzumab Govitecan In TNBC

for Invasive Breast Cancer

Sites in Boston, Newton & Danvers

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04230109·Phase 2·Recruiting·Listed Jan 2020

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Paxalisib (GDC-0084) In Recurrent Or Refractory PCNSL

for Primary Central Nervous System Lymphoma

2 locations in Boston

Sponsor: Lakshmi Nayak, MD

Sex: All·Age: 18+

Code: NCT04906096·Phase 2·Recruiting·Listed May 2021

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NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

for Adipocytic Neoplasm

Drug: Selinexor

Sites in Boston +6 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 30

Code: NCT06239272·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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A Pilot of a Microdevice For In Situ Candidate Drug Screening in Cutaneous Lesions of T-Cell Lymphoma

for Cutaneous T Cell Lymphoma

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04045470·Recruiting·Listed Aug 2019

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ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas

for Neurological Cancer

3 locations in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03922555·Phase 1·Recruiting·Listed Apr 2019

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Palbociclib and Pembrolizumab In Central Nervous System Metastases

for Metastatic Malignant Neoplasm to Brain

2 locations in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT02896335·Phase 2·Recruiting·Listed Sep 2016

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Jump: MR Simulation For Radiation Therapy Master Protocol

for Prostate Cancer

2 locations in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT04545957·Recruiting·Listed Sep 2020

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Immuno-PRISM (PRecision Intervention Smoldering Myeloma)

for High-risk Smoldering Multiple Myeloma

Sites in Boston +2 more locations

Sponsor: Irene Ghobrial, MD

Sex: All·Age: 18+

Code: NCT05469893·Phase 2·Recruiting·Listed Jul 2022

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Adjuvant Chemotherapy and Immunotherapy for Completely Resected Small Cell Lung Cancer

for Small Cell Lung Cancer (SCLC)

Sites in Boston +2 more locations

Sponsor: Alliance Foundation Trials, LLC.

Sex: All·Age: 18+

Code: NCT07149363·Phase 2·Recruiting·Listed Sep 2025

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SURGE: Supporting Utility and Representation in Genomics-based Cancer Trial Enrollment (Intervention)

for Gastrointestinal Cancer

Sites in Boston, Brighton & Methuen

Sponsor: Nadine Jackson, MD, MPH

Sex: All·Age: 18+

Code: NCT05375643·Recruiting·Listed May 2022

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RESOLVE: Abemaciclib + Letrozole +/- Metformin or Gedatolisib in Endometrial Cancer

for Endometrial Cancer

3 locations in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18+

Code: NCT03675893·Phase 2·Recruiting·Listed Sep 2018

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TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients

for Breast Cancer

Sites in Boston +3 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 65+

Code: NCT05535192·Recruiting·Listed Sep 2022

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A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation

for Acute Myeloid Leukemia

2 locations in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 12+

Code: NCT04024761·Phase 1·Recruiting·Listed Jul 2019

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Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy

for Androgen Deprivation Therapy

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Male·Age: 18+

Code: NCT05327465·Recruiting·Listed Apr 2022

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Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study

for Ovarian Cancer

Sites in Boston +8 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT05287451·Recruiting·Listed Mar 2022

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Ivosidenib as Post-HSCT Maintenance for AML

for IDH1 Mutation

Sites in Boston +5 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT06707493·Phase 2·Recruiting·Listed Nov 2024

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Scalp Cooling in MBC

for Metastatic Breast Cancer

2 locations in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04986579·Phase 2·Recruiting·Listed Aug 2021

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Hereditary Risk Factors for Thyroid Cancer

for Thyroid Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT02747888·Recruiting·Listed Apr 2016

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Pembrolizumab and Brentuximab Vedotin in Subjects With Relapsed/Refractory T-cell Lymphoma

for T-Cell Lymphoma

Sites in Boston +1 more location

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05313243·Phase 2·Recruiting·Listed Apr 2022

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Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals

for Pancreatic Cancer

2 locations in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06122896·EARLY_Phase 1·Recruiting·Listed Nov 2023

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Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

for Breast Cancer

Sites in Boston, Foxborough +13 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04468061·Phase 2·Recruiting·Listed Jul 2020

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Microdevice In Ovarian, Fallopian Tube, And Peritoneal Cancer

for Ovarian Cancer

2 locations in Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 18+

Code: NCT04701645·Phase 1·Recruiting·Listed Jan 2021

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Video Inspired Discussions About Ethical Outcomes in Pediatrics

for Pediatric Cancer

Sites in Boston +2 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: All ages

Code: NCT06786104·Recruiting·Listed Jan 2025

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Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer

for Non-small Cell Lung Cancer

2 locations in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04789486·Phase 1, Phase 2·Recruiting·Listed Mar 2021

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Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas

for Colonic Neoplasms

Sites in Boston +7 more locations

Sponsor: University of Michigan Rogel Cancer Center

Sex: All·Age: 18+

Code: NCT00843375·Recruiting·Listed Feb 2009

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Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors

for Acneiform Eruption Due to Chemical

Sites in Boston +8 more locations

Sponsor: Hoth Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05639933·Phase 2·Recruiting·Listed Dec 2022

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Study of the CDK4/6 Inhibitor Abemaciclib in Solid Tumors Harboring Genetic Alterations in Genes Encoding D-Type Cyclins or Amplification of CDK4 or CDK6

for Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT03310879·Phase 2·Recruiting·Listed Oct 2017

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Understanding Chronic Lymphocytic Leukemia

for Chronic Lymphocytic Leukemia

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04028531·Recruiting·Listed Jul 2019

Apply to this trial