Clinical Trials at Dana Farber Cancer Institute

As of July 2026, 229 paid clinical trials are recruiting at Dana Farber Cancer Institute, located at Dana-Farber Cancer Institute Longwood Center, 360 Longwood Ave, Boston, MA 02215 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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229 clinical trials at Dana Farber Cancer Institute

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A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)

for Hairy Cell Leukemia

Drug: Rituximab

10 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06561360·Phase 2·Recruiting

Apply to this trial

Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL

for Lymphoma

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06475235·Phase 1·Recruiting

Apply to this trial

Sleep Treatment Education Program for Cancer Survivors: STEP-Together

for Insomnia

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT06736548·Recruiting

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Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors

for Hematopoietic Stem Cell Transplant

3 locations incl. Tampa

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06328127·Recruiting

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NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

for Adipocytic Neoplasm

Drug: Selinexor

7 locations incl. Atlanta

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 30

Code: NCT06239272·Phase 1, Phase 2·Recruiting

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PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

for Head and Neck Cancer

2 locations incl. Boston

Sponsor: Glenn J. Hanna

Sex: All·Age: 18+

Code: NCT06239220·Phase 2·Recruiting

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Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals

for Pancreatic Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06122896·EARLY_Phase 1·Recruiting

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Pembrolizumab and Brentuximab Vedotin in Subjects With Relapsed/Refractory T-cell Lymphoma

for T-Cell Lymphoma

2 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05313243·Phase 2·Recruiting

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CB-103 With Either Lenvatinib or Abemaciclib in Patients With NOTCH ACC

for Adenoid Cystic Carcinoma

1 location in Boston

Sponsor: Glenn J. Hanna

Sex: All·Age: 18+

Code: NCT05774899·Phase 1, Phase 2·Recruiting

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High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumors: A Pilot Feasibility Study

for Pediatric Brain Tumor

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05740839·Recruiting

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Phase 2 Study of Glofitamab Monotherapy & With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation

for Chronic Lymphocytic Leukemia

Drug: Polatuzumab Vedotin

5 locations incl. Atlanta

Sponsor: Christine Ryan

Sex: All·Age: 18+

Code: NCT06043674·Phase 2·Recruiting

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Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study

for Ovarian Cancer

9 locations incl. Boston

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT05287451·Recruiting

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Microdevice In Ovarian, Fallopian Tube, And Peritoneal Cancer

for Ovarian Cancer

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 18+

Code: NCT04701645·Phase 1·Recruiting

Apply to this trial

Scalp Cooling in MBC

for Metastatic Breast Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04986579·Phase 2·Recruiting

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TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients

for Breast Cancer

3 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 65+

Code: NCT05535192·Recruiting

Apply to this trial

Hereditary Risk Factors for Thyroid Cancer

for Thyroid Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT02747888·Recruiting

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Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer

for Non-small Cell Lung Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04789486·Phase 1, Phase 2·Recruiting

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Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas

for Colonic Neoplasms

11 locations incl. Los Angeles

Sponsor: University of Michigan Rogel Cancer Center

Sex: All·Age: 18+

Code: NCT00843375·Recruiting

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Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

for Multiple Myeloma

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT03689595·Recruiting

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Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

for Brain Cancer

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT04899908·Phase 2·Recruiting

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A Study of Ruxolitinib and Duvelisib in People With Lymphoma

for T-cell Lymphomas

Drug: Ruxolitinib

9 locations incl. Miami

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT05010005·Phase 1·Recruiting

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Post-op T-DM1 in HER-2+ Salivary Gland Carcinomas

for Salivary Gland Cancer

13 locations incl. Atlanta

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04620187·Phase 2·Recruiting

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Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.

for Anatomic Stage IV Breast Cancer AJCC v8

6 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 70+

Code: NCT04305834·Phase 2·Recruiting

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Study of Ruxolitinib in Relapsed or Refractory T or NK Cell Lymphoma

for Lymphoma

Drug: Ruxolitinib

10 locations incl. Miami

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT02974647·Phase 2·Recruiting

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Study of the CDK4/6 Inhibitor Abemaciclib in Solid Tumors Harboring Genetic Alterations in Genes Encoding D-Type Cyclins or Amplification of CDK4 or CDK6

for Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT03310879·Phase 2·Recruiting

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Understanding Chronic Lymphocytic Leukemia

for Chronic Lymphocytic Leukemia

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04028531·Recruiting

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Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers

for Salivary Gland Cancer

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05553782·EARLY_Phase 1·Recruiting

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PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recovery

for Malignant Female Reproductive System Neoplasm

2 locations incl. San Francisco

Sponsor: University of California, San Francisco

Sex: Female·Age: 18+

Code: NCT06089083·Recruiting

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Pilot of 18F-DCFPyL-PSMA PET in mCRPC Patients Receiving 117Lu-Vipivotide Tetraxetan

for Prostate Cancer

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 18+

Code: NCT06099093·Phase 4·Recruiting

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Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)

for Breast Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18 - 59·Accepts healthy volunteers

Code: NCT06322888·Recruiting

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Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial

for Graft Vs Host Disease

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05236062·Recruiting

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Treatment Response Assessment Maps to Delineate Necrosis From Tumor After Stereotactic Radiation in Brain Metastases

for Brain Tumor

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT04033497·Recruiting

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Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma

for Head and Neck Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT03875716·Recruiting

Apply to this trial

Palbociclib and Pembrolizumab In Central Nervous System Metastases

for Metastatic Malignant Neoplasm to Brain

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT02896335·Phase 2·Recruiting

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Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation

for Multiple Myeloma

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05706766·Recruiting

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Resistance Exercise Combined With Protein Supplementation in People With Pancreatic Cancer: The RE-BUILD Trial

for Pancreatic Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05356117·Recruiting

Apply to this trial

Pilot Study for Detection of PSMA-Low CRPC-NE Tumors With Fluciclovine PET/CT

for Advanced Prostate Cancer

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 18+

Code: NCT06062745·Phase 1·Recruiting

Apply to this trial

Exercise as a Preventive Agent to Combat Immobility in Patients With Ovarian or Endometrial Cancers Receiving Chemotherapy

for Ovarian Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18+

Code: NCT04997096·Recruiting

Apply to this trial

Checkpoint Inhibition In Pediatric Hepatocellular Carcinoma

for Hepatocellular Carcinoma, Childhood

5 locations incl. San Francisco

Sponsor: Allison O'Neill, MD

Sex: All·Age: 0 - 30

Code: NCT04134559·Phase 2·Recruiting

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ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas

for Neurological Cancer

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03922555·Phase 1·Recruiting

Apply to this trial