Clinical Trials at Massachusetts General Hospital

As of July 2026, 599 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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604 clinical trials at Massachusetts General Hospital

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Computational Neuroscience of Language Processing in the Human Brain

for Language

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT05222594·Recruiting·Listed Feb 2022

Apply to this trial

Buspirone and Melatonin for Depression Following Traumatic Brain Injury

for Depression

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 64

Code: NCT04400266·Phase 4·Recruiting·Listed May 2020

Apply to this trial

Preventing Childbirth-Related PTSD With Expressive Writing

for PTSD (Childbirth-Related)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 50·Accepts healthy volunteers

Code: NCT05662423·Recruiting·Listed Dec 2022

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Biomarkers in Infection

for Sepsis

2 locations incl. Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT02545478·Recruiting·Listed Sep 2015

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G-CSF After Chemo-radiation in Patients With Glioblastoma

for MGMT-Methylated Glioblastoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06649851·Phase 2·Recruiting·Listed Oct 2024

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COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

for Colorectal Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05692024·Phase 1, Phase 2·Recruiting·Listed Jan 2023

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Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

for Atherosclerosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 30 - 65·Accepts healthy volunteers

Code: NCT04496947·Recruiting·Listed Aug 2020

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Impact of Pectoral Versus Paravertebral Blocks on Pain and Physical Well-Being in Implant-Based Breast Reconstruction

for Breast Reconstruction

1 location in Boston

Sponsor: Amy Colwell

Sex: All·Age: 18+

Code: NCT07209436·Recruiting·Listed Oct 2025

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Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer

for Metastatic Colon Cancer

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03803553·Phase 3·Recruiting·Listed Jan 2019

Apply to this trial

Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

for Alzheimer Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 99·Accepts healthy volunteers

Code: NCT06538311·EARLY_Phase 1·Recruiting·Listed Aug 2024

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Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health

for Coronary Artery Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 30 - 75

Code: NCT07087431·Recruiting·Listed Jul 2025

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Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories

for Preeclampsia

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT07041281·Phase 2·Recruiting·Listed Jun 2025

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A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule

for Lynch Syndrome

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07219537·Recruiting·Listed Oct 2025

Apply to this trial

Feasibility and Acceptability of Primary Palliative Care Intervention in Patients Undergoing Hematopoietic Stem Cell Transplantation

for Hematopoietic Cell Transplant

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06676852·Recruiting·Listed Nov 2024

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Intraoperative Tumor Margin Identification With ICG Dye Imaging

for Benign Neoplasm

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04752137·Phase 2·Recruiting·Listed Feb 2021

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Romosozumab as an Adjunct to Physiologic Estrogen Replacement in Functional Hypothalamic Amenorrhea

for FHA (Functional Hypothalamic Amenorrhea)

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 14 - 30

Code: NCT06533865·Phase 3·Recruiting·Listed Aug 2024

Apply to this trial

Pain Outcomes After Digital Amputation Using Tulavi Allay™ Nerve Cap

for Neuroma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 22+

Code: NCT06915662·Phase 2·Recruiting·Listed Apr 2025

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Mg OSTEOCRETE Post-Treatment Outcomes

for Cancer of Bone

1 location in Boston

Sponsor: Santiago Lozano-Calderon

Sex: All·Age: 18+

Code: NCT06720142·Recruiting·Listed Dec 2024

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Vaginal Microbiota Transplant

for Recurrent Bacterial Vaginosis

1 location in Boston

Sponsor: Douglas Kwon

Sex: Female·Age: 18 - 50

Code: NCT04046900·Phase 1, Phase 2·Recruiting·Listed Aug 2019

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Advanced Imaging for Pulmonary Fibrosis

for Pulmonary Fibrosis

1 location in Boston

Sponsor: Peter Caravan

Sex: All·Age: 18 - 80

Code: NCT06532071·Phase 2·Recruiting·Listed Aug 2024

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Positive Emotions Following Acute Cardiac Events

for Acute Coronary Syndrome

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 95

Code: NCT05412862·Recruiting·Listed Jun 2022

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Collagen-targeted PET Imaging for Early Interstitial Lung Disease

for Interstitial Lung Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40+

Code: NCT05417776·Phase 2·Recruiting·Listed Jun 2022

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GpCRC Pediatric Gastroparesis Registry 2

for Gastroparesis

6 locations incl. Boston

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 8 - 25

Code: NCT05981300·Recruiting·Listed Aug 2023

Apply to this trial

Combined Anabolic Therapy

for Osteoporosis, Postmenopausal

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 45+·Accepts healthy volunteers

Code: NCT06558188·Phase 4·Recruiting·Listed Aug 2024

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MAGIC Ruxolitinib for aGVHD

for Acute Graft-versus-host Disease

Drug: Ruxolitinib

14 locations incl. Duarte

Sponsor: John Levine

Sex: All·Age: 18+

Code: NCT06936566·Phase 2·Recruiting·Listed Apr 2025

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Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

for Brain Tumor

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03286335·Recruiting·Listed Sep 2017

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Promoting Well-being and Health in Heart Failure

for Heart Failure

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04829617·Recruiting·Listed Apr 2021

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Boosting Emotional Well-being and Happiness in Outpatients Living With Diabetes

for Diabetes Mellitus, Type 2

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05420051·Recruiting·Listed Jun 2022

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Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners

for Nursing Home Resident

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07220486·Recruiting·Listed Oct 2025

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The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-cardiac for Postoperative Delirium

for Delirium, Postoperative

3 locations incl. Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 60+

Code: NCT06721819·Phase 3·Recruiting·Listed Dec 2024

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Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA

for Stomach Cancer Stage IV

Drug: Ivonescimab

2 locations incl. Santa Monica

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07070466·Phase 2·Recruiting·Listed Jul 2025

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Proton or Photon RT for Retroperitoneal Sarcomas

for Retroperitoneal Sarcoma

10 locations incl. Chicago

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT01659203·Phase 1, Phase 2·Recruiting·Listed Aug 2012

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Gastroparesis Registry 4

for Gastroparesis

6 locations incl. Scottsdale

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 18 - 85

Code: NCT05846802·Recruiting·Listed May 2023

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ELISA in Relapsed/Refractory MM

for Relapsed Refractory Multiple Myeloma (RRMM)

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06832865·Phase 2·Recruiting·Listed Feb 2025

Apply to this trial

Elranatamab in R/R Multiple Myeloma

for Refractory Multiple Myeloma

Drug: Elranatamab

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06138275·Phase 2·Recruiting·Listed Nov 2023

Apply to this trial

THRIVE-CAR-T Digital App

for CAR T-Cell Therapy

1 location in Boston

Sponsor: Patrick C. Johnson, MD

Sex: All·Age: 18+

Code: NCT06665295·Recruiting·Listed Oct 2024

Apply to this trial

Web-based Mind-body Program to Improve Resilience Among Risky Substance Users With Persistent Upper Extremity Pain

for Orthopedic Disorder

1 location in Boston

Sponsor: Jafar Bakhshaie

Sex: All·Age: 18+

Code: NCT06991205·Recruiting·Listed May 2025

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Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity

for Obesity

Drug: Tirzepatide

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05933499·Phase 2·Recruiting·Listed Jul 2023

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Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

for Advanced Ovarian Carcinoma

13 locations incl. Miami

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT04575935·Phase 3·Recruiting·Listed Oct 2020

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Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons

for Parkinson Disease

1 location in Boston

Sponsor: Jeffrey S. Schweitzer, MD, PhD

Sex: All·Age: 45 - 80

Code: NCT06687837·Phase 1·Recruiting·Listed Nov 2024

Apply to this trial