Clinical Trials at Massachusetts General Hospital

As of July 2026, 599 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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604 clinical trials at Massachusetts General Hospital

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Surgical Pembro +/- Olaparib w TMZ for rGBM

for Glioblastoma

4 locations incl. Boston

Sponsor: L. Nicolas Gonzalez Castro, MD, PhD

Sex: All·Age: 18+

Code: NCT05463848·Phase 2·Recruiting·Listed Jul 2022

Apply to this trial

JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction

for Patellar Dislocation, Recurrent

16 locations incl. Redwood City

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 10 - 35

Code: NCT06883396·Recruiting·Listed Mar 2025

Apply to this trial

Ketamine Treatment of Youth Suicide Attempters

for Suicide, Attempted

2 locations incl. Boston

Sponsor: Tatiana Falcone, MD

Sex: All·Age: 14 - 30

Code: NCT04763343·Phase 3·Recruiting·Listed Feb 2021

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Ziftomenib Maintenance Post Allo-HCT

for Acute Myeloid Leukemia

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06440135·Phase 1·Recruiting·Listed Jun 2024

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The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease

for Atherosclerosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 45 - 65

Code: NCT04505865·Recruiting·Listed Aug 2020

Apply to this trial

Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia

for Severe Aplastic Anemia

25 locations incl. Birmingham

Sponsor: Medical College of Wisconsin

Sex: All·Age: 3 - 75

Code: NCT06517641·Phase 2·Recruiting·Listed Jul 2024

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Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease

for Aortic Aneurysm

14 locations incl. Newport Beach

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04005976·Recruiting·Listed Jul 2019

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North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

for Mitochondrial Disorders

16 locations incl. San Diego

Sponsor: Columbia University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01694940·Recruiting·Listed Sep 2012

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Cortical-Basal Ganglia Speech Networks

for Parkinson Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT04286308·Recruiting·Listed Feb 2020

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Long-term Follow-up of Subjects Treated With CAR T Cells

for Long Term Adverse Effects

1 location in Boston

Sponsor: Marcela V. Maus, M.D.,Ph.D.

Sex: All·Age: 18+

Code: NCT05024175·Recruiting·Listed Aug 2021

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CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma

for Non-hodgkin Lymphoma

1 location in Boston

Sponsor: Marcela V. Maus, M.D.,Ph.D.

Sex: All·Age: 18+

Code: NCT06026319·Phase 1·Recruiting·Listed Sep 2023

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Efficacy of Synchronous, Virtual Cognitive Behavioral Therapy for Insomnia Across Phases of Cancer Survivorship

for Insomnia Chronic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: All ages

Code: NCT06807086·Recruiting·Listed Feb 2025

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Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery

for Drain Output After Breast Reduction Surgery

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT07131592·Phase 4·Recruiting·Listed Aug 2025

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Primary Tumor Research and Outcomes Network

for Spinal Column Tumor

9 locations incl. San Francisco

Sponsor: AO Innovation Translation Center

Sex: All·Age: All ages

Code: NCT02790983·Recruiting·Listed Jun 2016

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Initial Resuscitation for Acute Kidney Injury in Cirrhosis

for Cirrhosis, Liver

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06525623·Recruiting·Listed Jul 2024

Apply to this trial

Palbociclib and Pembrolizumab In Central Nervous System Metastases

for Metastatic Malignant Neoplasm to Brain

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT02896335·Phase 2·Recruiting·Listed Sep 2016

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Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer

for Impaired Cognition

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 60+·Accepts healthy volunteers

Code: NCT02290834·Recruiting·Listed Nov 2014

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The TEAM Study - Treatment Efficacy for Autism/Attention Using Mixed Amphetamine

for Attention Deficit Hyperactivity Disorder (ADHD)

1 location in Boston

Sponsor: Gagan Joshi

Sex: All·Age: 8 - 18·Accepts healthy volunteers

Code: NCT06853665·Phase 4·Recruiting·Listed Mar 2025

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Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease

for Bone Marrow Transplant Complications

2 locations incl. Miami

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06910969·Recruiting·Listed Apr 2025

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Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

for Subjective Cognitive Concerns

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05881239·Recruiting·Listed May 2023

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Multi-center Evaluation of the Clinical Utility of ESD in the Western Population

for Endoscopic Submucosal Dissection

3 locations incl. Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 100

Code: NCT02989818·Recruiting·Listed Dec 2016

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TMS for Cognitive Decline in Aging and Preclinical AD

for Prodromal Alzheimer&#39

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 99·Accepts healthy volunteers

Code: NCT06956300·Recruiting·Listed May 2025

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Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer, and Idiopathic Pulmonary Fibrosis Patients

for Pulmonary Fibrosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT03535545·Phase 1·Recruiting·Listed May 2018

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Positron Emission Tomography (PET) Imaging of Thrombosis

for Atrial Fibrillation

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT03830320·Phase 1·Recruiting·Listed Feb 2019

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Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury

for Lung Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT04485286·Phase 2·Recruiting·Listed Jul 2020

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Outpatient Epcoritamab as 2L in NTE R/R DLBCL

for Relapsed Large B-cell Lymphoma

Drug: Epcoritamab

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06811272·Phase 2·Recruiting·Listed Feb 2025

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Diet and Stress Management Combined With Advanced Therapy for Crohn's and Ulcerative Colitis

for IBD (Inflammatory Bowel Disease)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07168499·Recruiting·Listed Sep 2025

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Middle Meningeal Artery Embolization (MMAE) Outcomes for Chronic Subdural Hematoma (cSDH)

for Chronic Subdural Hematoma

15 locations incl. Coral Gables

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT06181994·Recruiting·Listed Dec 2023

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Platform Clinical Study for Conquering Scleroderma

for Interstitial Lung Disease Due to Systemic Disease

34 locations incl. Birmingham

Sponsor: Scleroderma Research Foundation, Inc.

Sex: All·Age: 18+

Code: NCT06195072·Phase 2·Recruiting·Listed Jan 2024

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Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool

for Tibia Fractures

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07193524·Recruiting·Listed Sep 2025

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Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery

for Postoperative Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04912531·Recruiting·Listed Jun 2021

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The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

for Mitral Annular Calcification

16 locations incl. Gilbert

Sponsor: Mayra Guerrero

Sex: All·Age: 18+

Code: NCT04408430·Recruiting·Listed May 2020

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Omalizumab Weight-Based Dosing Efficacy Trial

for Allergies

Drug: Omalizumab

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 1 - 55

Code: NCT06943534·Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

for Delirium, Postoperative

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 70+

Code: NCT06052397·Recruiting·Listed Sep 2023

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Oxytocin Effects on Bone in Children With Autism Spectrum Disorder

for Autism Spectrum Disorder

2 locations incl. Boston

Sponsor: Elizabeth Austen Lawson

Sex: All·Age: 6 - 18

Code: NCT05754073·Phase 2·Recruiting·Listed Mar 2023

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Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

for Generalized Anxiety Disorder

3 locations incl. Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 65

Code: NCT04557891·Recruiting·Listed Sep 2020

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Intermuscular Coherence as a Biomarker for ALS

for Amyotrophic Lateral Sclerosis

4 locations incl. Miami

Sponsor: University of Chicago

Sex: All·Age: 20 - 90·Accepts healthy volunteers

Code: NCT05104710·Recruiting·Listed Nov 2021

Apply to this trial

MOLAR: Mapping Oral Health and Local Area Resources

for Dental Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 1+

Code: NCT05688982·Recruiting·Listed Jan 2023

Apply to this trial

Cannabidiol for Reduction of Brain Neuroinflammation

for Back Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT05066308·Phase 2·Recruiting·Listed Oct 2021

Apply to this trial

Impact of Earplugs on Mechanisms of Noise-Related Cardiovascular Disease

for Cardiometabolic Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07148817·Recruiting·Listed Aug 2025

Apply to this trial