Clinical Trials at Massachusetts General Hospital

As of September 2026, 602 paid clinical trials are recruiting at Massachusetts General Hospital, located at 55 FRUIT ST, CARDIOLOGY, GRB 800, MS 843, BOSTON, MA 02114-2621, phone (617) 724-1935 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

Filter results

Filter results

State

City

Facility

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

603 clinical trials at Massachusetts General Hospital

·Clear filters·

Get a weekly email when new trials open in Boston, MA.

Mg OSTEOCRETE Post-Treatment Outcomes

for Cancer of Bone

1 location in Boston

Sponsor: Santiago Lozano-Calderon

Sex: All·Age: 18+

Code: NCT06720142·Recruiting·Listed Dec 2024

Apply to this trial

Advanced Imaging for Pulmonary Fibrosis

for Pulmonary Fibrosis

1 location in Boston

Sponsor: Peter Caravan

Sex: All·Age: 18 - 80

Code: NCT06532071·Phase 2·Recruiting·Listed Aug 2024

Apply to this trial

MAGIC Ruxolitinib for aGVHD

for Acute Graft-versus-host Disease

Drug: Ruxolitinib

Sites in Boston +13 more locations

Sponsor: John Levine

Sex: All·Age: 18+

Code: NCT06936566·Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

Positive Emotions Following Acute Cardiac Events

for Acute Coronary Syndrome

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 95

Code: NCT05412862·Recruiting·Listed Jun 2022

Apply to this trial

Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

for Alzheimer Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 99·Accepts healthy volunteers

Code: NCT06538311·EARLY_Phase 1·Recruiting·Listed Aug 2024

Apply to this trial

Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

for PTSD

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07260032·Recruiting·Listed Dec 2025

Apply to this trial

Pain Outcomes After Digital Amputation Using Tulavi Allay™ Nerve Cap

for Neuroma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 22+

Code: NCT06915662·Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease

for Aortic Aneurysm

Sites in Boston +13 more locations

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04005976·Recruiting·Listed Jul 2019

Apply to this trial

North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

for Mitochondrial Disorders

Sites in Boston +15 more locations

Sponsor: Columbia University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01694940·Recruiting·Listed Sep 2012

Apply to this trial

Combined Anabolic Therapy

for Osteoporosis, Postmenopausal

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 45+·Accepts healthy volunteers

Code: NCT06558188·Phase 4·Recruiting·Listed Aug 2024

Apply to this trial

Promoting Well-being and Health in Heart Failure

for Heart Failure

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04829617·Recruiting·Listed Apr 2021

Apply to this trial

Boosting Emotional Well-being and Happiness in Outpatients Living With Diabetes

for Diabetes Mellitus, Type 2

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05420051·Recruiting·Listed Jun 2022

Apply to this trial

JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction

for Patellar Dislocation, Recurrent

Sites in Boston +15 more locations

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 10 - 35

Code: NCT06883396·Recruiting·Listed Mar 2025

Apply to this trial

Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories

for Preeclampsia

Sites in Boston +2 more locations

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT07041281·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia

for Severe Aplastic Anemia

Sites in Boston +24 more locations

Sponsor: Medical College of Wisconsin

Sex: All·Age: 3 - 75

Code: NCT06517641·Phase 2·Recruiting·Listed Jul 2024

Apply to this trial

Momelotinib During and After HCT in Myelofibrosis

for Myelofibrosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07104799·Phase 1·Recruiting·Listed Aug 2025

Apply to this trial

The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-cardiac for Postoperative Delirium

for Delirium, Postoperative

Sites in Boston +2 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 60+

Code: NCT06721819·Phase 3·Recruiting·Listed Dec 2024

Apply to this trial

Gastroparesis Registry 4

for Gastroparesis

Sites in Boston +5 more locations

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 18 - 85

Code: NCT05846802·Recruiting·Listed May 2023

Apply to this trial

Primary Tumor Research and Outcomes Network

for Spinal Column Tumor

Sites in Boston +6 more locations

Sponsor: AO Innovation Translation Center

Sex: All·Age: All ages

Code: NCT02790983·Recruiting·Listed Jun 2016

Apply to this trial

THRIVE-CAR-T Digital App

for CAR T-Cell Therapy

1 location in Boston

Sponsor: Patrick C. Johnson, MD

Sex: All·Age: 18+

Code: NCT06665295·Recruiting·Listed Oct 2024

Apply to this trial

Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity

for Obesity

Drug: Tirzepatide

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05933499·Phase 2·Recruiting·Listed Jul 2023

Apply to this trial

The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

for Mitral Annular Calcification

Sites in Boston +12 more locations

Sponsor: Mayra Guerrero

Sex: All·Age: 18+

Code: NCT04408430·Recruiting·Listed May 2020

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

Sites in Boston +56 more locations

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting·Listed Dec 2022

Apply to this trial

Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons

for Parkinson Disease

1 location in Boston

Sponsor: Jeffrey S. Schweitzer, MD, PhD

Sex: All·Age: 45 - 80

Code: NCT06687837·Phase 1·Recruiting·Listed Nov 2024

Apply to this trial

Impact of Pectoral Versus Paravertebral Blocks on Pain and Physical Well-Being in Implant-Based Breast Reconstruction

for Breast Reconstruction

1 location in Boston

Sponsor: Amy Colwell

Sex: All·Age: 18+

Code: NCT07209436·Recruiting·Listed Oct 2025

Apply to this trial

Web-based Mind-body Program to Improve Resilience Among Risky Substance Users With Persistent Upper Extremity Pain

for Orthopedic Disorder

1 location in Boston

Sponsor: Jafar Bakhshaie

Sex: All·Age: 18+

Code: NCT06991205·Recruiting·Listed May 2025

Apply to this trial

The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease

for Atherosclerosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 45 - 65

Code: NCT04505865·Recruiting·Listed Aug 2020

Apply to this trial

A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

for Cystic Fibrosis

Sites in Boston, Worcester +66 more locations

Sponsor: Nicole Hamblett

Sex: All·Age: 12+

Code: NCT06504589·Recruiting·Listed Jul 2024

Apply to this trial

A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule

for Lynch Syndrome

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07219537·Recruiting·Listed Oct 2025

Apply to this trial

Restarting Triple Therapy With Robust Monitoring for Adverse Events (RETRIAL)

for Cystic Fibrosis

Sites in Boston +17 more locations

Sponsor: Boston Children's Hospital

Sex: All·Age: 6+

Code: NCT06683092·Recruiting·Listed Nov 2024

Apply to this trial

Long-term Follow-up of Subjects Treated With CAR T Cells

for Long Term Adverse Effects

1 location in Boston

Sponsor: Marcela V. Maus, M.D.,Ph.D.

Sex: All·Age: 18+

Code: NCT05024175·Recruiting·Listed Aug 2021

Apply to this trial

CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma

for Non-hodgkin Lymphoma

1 location in Boston

Sponsor: Marcela V. Maus, M.D.,Ph.D.

Sex: All·Age: 18+

Code: NCT06026319·Phase 1·Recruiting·Listed Sep 2023

Apply to this trial

Efficacy of Synchronous, Virtual Cognitive Behavioral Therapy for Insomnia Across Phases of Cancer Survivorship

for Insomnia Chronic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: All ages

Code: NCT06807086·Recruiting·Listed Feb 2025

Apply to this trial

Initial Resuscitation for Acute Kidney Injury in Cirrhosis

for Cirrhosis, Liver

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06525623·Recruiting·Listed Jul 2024

Apply to this trial

The TEAM Study - Treatment Efficacy for Autism/Attention Using Mixed Amphetamine

for Attention Deficit Hyperactivity Disorder (ADHD)

1 location in Boston

Sponsor: Gagan Joshi

Sex: All·Age: 8 - 18·Accepts healthy volunteers

Code: NCT06853665·Phase 4·Recruiting·Listed Mar 2025

Apply to this trial

Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

for Subjective Cognitive Concerns

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05881239·Recruiting·Listed May 2023

Apply to this trial

Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease

for Bone Marrow Transplant Complications

Sites in Boston +1 more location

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06910969·Recruiting·Listed Apr 2025

Apply to this trial

Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

for Delirium, Postoperative

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 70+

Code: NCT06052397·Recruiting·Listed Sep 2023

Apply to this trial

Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients

for Insomnia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65+

Code: NCT06375265·Recruiting·Listed Apr 2024

Apply to this trial

Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners

for Nursing Home Resident

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07220486·Recruiting·Listed Oct 2025

Apply to this trial