Clinical Trials at Massachusetts General Hospital

As of July 2026, 599 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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604 clinical trials at Massachusetts General Hospital

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Ruxolitinib in Thrombocythemia and Polycythemia Vera

for Essential Thrombocythemia

Drug: Ruxolitinib

4 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04644211·Phase 2·Recruiting·Listed Nov 2020

Apply to this trial

Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

for Ulcerative Colitis

13 locations incl. Birmingham

Sponsor: Northwestern University

Sex: All·Age: 18 - 85

Code: NCT05987852·Recruiting·Listed Aug 2023

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Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

for Emotional Distress

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07143357·Recruiting·Listed Aug 2025

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Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

for Inflammatory Bowel Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14+·Accepts healthy volunteers

Code: NCT05332639·Recruiting·Listed Apr 2022

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Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure

for Blast Injury

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Male·Age: 18 - 50

Code: NCT07131475·Phase 2·Recruiting·Listed Aug 2025

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Left vs Left Randomized Clinical Trial

for Heart Failure

57 locations incl. Gilbert

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting·Listed Dec 2022

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Restarting Triple Therapy With Robust Monitoring for Adverse Events (RETRIAL)

for Cystic Fibrosis

18 locations incl. Birmingham

Sponsor: Boston Children's Hospital

Sex: All·Age: 6+

Code: NCT06683092·Recruiting·Listed Nov 2024

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National Liver Cancer Screening Trial

for Carcinoma, Hepatocellular

18 locations incl. Los Angeles

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 85

Code: NCT06084234·Phase 4·Recruiting·Listed Oct 2023

Apply to this trial

Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

31 locations incl. Phoenix

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting·Listed Jun 2021

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REcovery From DEXmedetomidine-induced Unconsciousness

for Anesthesia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06003127·Recruiting·Listed Aug 2023

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A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

for Cystic Fibrosis

68 locations incl. Birmingham

Sponsor: Nicole Hamblett

Sex: All·Age: 12+

Code: NCT06504589·Recruiting·Listed Jul 2024

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Online Parent Education for Child Anxiety

for Anxiety Disorders

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07153250·Recruiting·Listed Sep 2025

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IlluminOss Photodynamic Bone Stabilization System for the Treatment of Impending and Actual Pelvis Fractures

for Cancer Metastatic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 21+

Code: NCT04842266·Recruiting·Listed Apr 2021

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The CurePSP Genetics Program

for PSP

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 35+·Accepts healthy volunteers

Code: NCT06647641·Recruiting·Listed Oct 2024

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Isatuximab, Bela Maf, Pom, and Dex in Relapsed/Refractory Multiple Myeloma

for Relapsed Cancer

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05922501·Phase 2·Recruiting·Listed Jun 2023

Apply to this trial

PRIMARY Ancillary Substudy

for Mitral Valve Prolapse

16 locations incl. Los Angeles

Sponsor: Annetine Gelijns

Sex: All·Age: 60+

Code: NCT07103733·Recruiting·Listed Aug 2025

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Early Internal Fixation Versus NonOperative Care With Early Rehabilitation for LC1 Fragility Fractures of the Pelvis

for Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring

12 locations incl. Phoenix

Sponsor: University of Southern California

Sex: All·Age: 60+

Code: NCT06496867·Recruiting·Listed Jul 2024

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Quality of Pediatric Resuscitation in a Multicenter Collaborative

for Cardiac Arrest

40 locations incl. Los Angeles

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 - 18

Code: NCT02708134·Recruiting·Listed Mar 2016

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Health Outcomes of Parents With Cystic Fibrosis-Aim 2

for Cystic Fibrosis

18 locations incl. Birmingham

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT06296394·Recruiting·Listed Mar 2024

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Abatacept in Immune Checkpoint Inhibitor Myocarditis

for Myocarditis Acute

29 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05335928·Phase 3·Recruiting·Listed Apr 2022

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Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials

for Stroke

45 locations incl. Birmingham

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05338697·Recruiting·Listed Apr 2022

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Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV)

for Cytomegalovirus

2 locations incl. Boston

Sponsor: Camille N. Kotton, MD

Sex: All·Age: 18 - 75

Code: NCT06958796·Phase 4·Recruiting·Listed May 2025

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Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma

for Melanoma

Drug: Ipilimumab

4 locations incl. Los Angeles

Sponsor: NYU Langone Health

Sex: All·Age: 18 - 100

Code: NCT05428007·Phase 2·Recruiting·Listed Jun 2022

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Biomarker Development for Muscular Dystrophies

for Myotonic Dystrophy

5 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT05019625·Recruiting·Listed Aug 2021

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Extracellular RNA Biomarkers of Myotonic Dystrophy

for Myotonic Dystrophy

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT05020002·Recruiting·Listed Aug 2021

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Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

for Amyotrophic Lateral Sclerosis

10 locations incl. Phoenix

Sponsor: Target ALS Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05137665·Recruiting·Listed Nov 2021

Apply to this trial

BRIDGE: Blood Pressure Reduction and Intervention Delivery Via Group Engagement

for Stroke

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 35+

Code: NCT07091851·Recruiting·Listed Jul 2025

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Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance

for Ascending Aortic Aneurysm Enlargement

15 locations incl. San Francisco

Sponsor: Ottawa Heart Institute Research Corporation

Sex: All·Age: 18 - 79

Code: NCT03536312·Recruiting·Listed May 2018

Apply to this trial

Prospective Screening for Breast Cancer-related Lymphedema

for Lymphedema

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT01521741·Recruiting·Listed Jan 2012

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Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population

for Overweight

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT05799222·Recruiting·Listed Apr 2023

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Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer

for Early-stage Breast Cancer

9 locations incl. Fullerton

Sponsor: Jonsson Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT04553770·Phase 2·Recruiting·Listed Sep 2020

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The PREGNANT (Pregnant Resident Empowerment, GuidaNce, and Advocacy iN Training) Coaching Project

for Burnout, Professional

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07221422·Recruiting·Listed Oct 2025

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Extracellular RNA Biomarkers of Duchenne Muscular Dystrophy

for Duchenne Muscular Dystrophy

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 5+

Code: NCT05016908·Recruiting·Listed Aug 2021

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Developing Fast Pediatric Imaging

for Pediatric Low-grade Gliomas

3 locations incl. Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0+·Accepts healthy volunteers

Code: NCT03761121·Recruiting·Listed Dec 2018

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Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South Africa: Part 2

for Cervical Cancer

2 locations incl. Boston

Sponsor: Boston University Charles River Campus

Sex: Female·Age: 18+

Code: NCT06182241·Recruiting·Listed Dec 2023

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INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

for Glioblastoma

12 locations incl. Boston

Sponsor: Patrick Wen, MD

Sex: All·Age: 18+

Code: NCT02977780·Phase 2·Recruiting·Listed Nov 2016

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Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance

for Crohn Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07033208·Recruiting·Listed Jun 2025

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REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women

for Coronary Artery Disease

18 locations incl. Glendale

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06399692·Phase 3·Recruiting·Listed May 2024

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REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities

for Coronary Artery Disease

18 locations incl. Glendale

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06399705·Phase 3·Recruiting·Listed May 2024

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Biology of Young Lung Cancer Study: The YOUNG LUNG Study

for Non Small Cell Lung Cancer

4 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 15+

Code: NCT05265429·Recruiting·Listed Mar 2022

Apply to this trial