Clinical Trials at Massachusetts General Hospital

As of July 2026, 599 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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604 clinical trials at Massachusetts General Hospital

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Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.

for Post Traumatic Stress Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07079761·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

Intermittent Fasting for NAFLD in Adults

for Fatty Liver

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04899102·Recruiting·Listed May 2021

Apply to this trial

Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

for Relapsed Adult AML

20 locations incl. Birmingham

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT05237258·Recruiting·Listed Feb 2022

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The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis

for Autoimmune Encephalitis

Drug: Inebilizumab

35 locations incl. Birmingham

Sponsor: University of Utah

Sex: All·Age: 12+

Code: NCT04372615·Phase 2·Recruiting·Listed May 2020

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Turmeric for Patients With Basal Joint Arthritis

for Thumb Osteoarthritis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40+

Code: NCT03017118·Recruiting·Listed Jan 2017

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Patient-centered, Optimal Integration of Survivorship and Palliative Care

for Stage IV Non-small Cell Lung Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04900935·Recruiting·Listed May 2021

Apply to this trial

Cerebrospinal Fluid Biomarkers of Myotonic Dystrophy

for Myotonic Dystrophy Type 1

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06075693·Recruiting·Listed Oct 2023

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Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

for Metastatic Breast Cancer

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06795529·Recruiting·Listed Jan 2025

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Decompression Versus Decompression and Fusion

for Adjacent Segment Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04542720·Recruiting·Listed Sep 2020

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Comparative-effectiveness of a Healthy Lifestyle and Asthma Management Program, In-person vs. ONline

for Overweight, Childhood

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 4 - 17

Code: NCT06432790·Recruiting·Listed May 2024

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Improving Health for Older Adults With Pain Through Engagement

for Chronic Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55+

Code: NCT06119698·Recruiting·Listed Nov 2023

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Emapalumab Prevention of CAR-T Cell Associated Toxicities

for Large B-cell Lymphoma

2 locations incl. Boston

Sponsor: Marcela V. Maus, M.D.,Ph.D.

Sex: All·Age: 18+

Code: NCT06550141·Phase 2·Recruiting·Listed Aug 2024

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Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)

for CHF

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06169540·Recruiting·Listed Dec 2023

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Efgartigimod for the Treatment of Acute Optic Neuritis

for Optic Neuritis

2 locations incl. Boston

Sponsor: Anastasia Vishnevetsky, MD, MPH

Sex: All·Age: 18+

Code: NCT06453694·Phase 2·Recruiting·Listed Jun 2024

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Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer

for Prostate Cancer

5 locations incl. Washington D.C.

Sponsor: Adam S. Kibel, MD

Sex: Male·Age: 40 - 69·Accepts healthy volunteers

Code: NCT06398639·Recruiting·Listed May 2024

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Physiology of Human Brain Connectivity

for Healthy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 64·Accepts healthy volunteers

Code: NCT06246942·Recruiting·Listed Feb 2024

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Bronchial NIR Image-guided Resection

for Sentinel Lymph Node

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03097575·Phase 1, Phase 2·Recruiting·Listed Mar 2017

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A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia

for Keratoconus

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 20 - 75·Accepts healthy volunteers

Code: NCT02118922·Recruiting·Listed Apr 2014

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Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

for Surgery-Complications

20 locations incl. Little Rock

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT05991453·Recruiting·Listed Aug 2023

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Developing Viability Index for Machine Perfused Livers

for Liver Cirrhoses

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT03694691·Recruiting·Listed Oct 2018

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Improving Coronary Vascular Health in Women

for HIV-1-infection

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 45 - 75

Code: NCT06843902·Phase 2·Recruiting·Listed Feb 2025

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Assess Fibrin in Brains With AD/ADRD

for Alzheimer Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05336695·Phase 1, Phase 2·Recruiting·Listed Apr 2022

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A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students

for Substance Use

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 9 - 22

Code: NCT06115746·Recruiting·Listed Nov 2023

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Mapping Auricular Vagus Nerve Circuitry

for Healthy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT00200889·EARLY_Phase 1·Recruiting·Listed Sep 2005

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National Pregnancy Registry for Psychiatric Medications

for Pregnant Women

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT01246765·Recruiting·Listed Nov 2010

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Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System

for Barrett's Esophagus

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14 - 85·Accepts healthy volunteers

Code: NCT02947971·Recruiting·Listed Oct 2016

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Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus

for Barrett Esophagus

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03830801·Recruiting·Listed Feb 2019

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Flotufolastat F 18 PET in Men With Very Low PSA Recurrence

for Prostate Cancer (Adenocarcinoma)

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Male·Age: 18+

Code: NCT06862856·Recruiting·Listed Mar 2025

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Towards Testing the Effectiveness of Recovery Community Centers (RCCs)

for Opioid Use Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07010978·Recruiting·Listed Jun 2025

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Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05523817·Recruiting·Listed Aug 2022

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Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation

for Asthma

1 location in Boston

Sponsor: Benjamin Medoff

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT00595491·Phase 1·Recruiting·Listed Jan 2008

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Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout

for Gout

7 locations incl. South Birmingham

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 90

Code: NCT04875702·Phase 4·Recruiting·Listed May 2021

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Exposure-Based CBT for Avoidant/Restrictive Food Intake in Functional Dyspepsia

for Avoidant/Restrictive Food Intake Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05587127·Recruiting·Listed Oct 2022

Apply to this trial

Safety and Efficacy of Atorvastatin v. Placebo on HCC Risk

for Liver Fibroses

2 locations incl. Boston

Sponsor: Raymond Chung

Sex: All·Age: 18+

Code: NCT05028829·Phase 2·Recruiting·Listed Aug 2021

Apply to this trial

Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV

for Hiv

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06001814·Recruiting·Listed Aug 2023

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Developing a Test of Uterine Lavage for the Detection of Ovarian Cancer

for Ovarian Neoplasms

6 locations incl. Little Rock

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 30+

Code: NCT04794322·Recruiting·Listed Mar 2021

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Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT05570812·Phase 2·Recruiting·Listed Oct 2022

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An Ethical Approach to Detecting Covert Consciousness

for Disorder of Consciousness

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05010265·Recruiting·Listed Aug 2021

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Phase II Study of Proton Radiation Therapy for Neuroblastoma

for Neuroblastoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 6 Months - 25

Code: NCT02112617·Recruiting·Listed Apr 2014

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From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects

for Chronic Pain

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT05661903·Phase 2·Recruiting·Listed Dec 2022

Apply to this trial