Clinical Trials at Massachusetts General Hospital

As of July 2026, 599 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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604 clinical trials at Massachusetts General Hospital

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Comprehensive HHT Outcomes Registry of the United States (CHORUS)

for Hereditary Hemorrhagic Telangiectasia

16 locations incl. Birmingham

Sponsor: Cure HHT

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06259292·Recruiting·Listed Feb 2024

Apply to this trial

Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech

for Stuttering, Developmental

3 locations incl. Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 6+·Accepts healthy volunteers

Code: NCT05437159·Recruiting·Listed Jun 2022

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Computerized Registry of Patients With Venous Thromboembolism (RIETE)

for Venous Thromboembolism

6 locations incl. Jacksonville

Sponsor: Manuel Monreal

Sex: All·Age: All ages

Code: NCT02832245·Recruiting·Listed Jul 2016

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Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

for Alzheimer's Disease

2 locations incl. Boston

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 120

Code: NCT05658913·Recruiting·Listed Dec 2022

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Mitral Valve Screening Survey

for Mitral Valve Disease

14 locations incl. Phoenix

Sponsor: Medstar Health Research Institute

Sex: All·Age: 18+

Code: NCT04736667·Recruiting·Listed Feb 2021

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Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients

for Sensation Disorders

2 locations incl. Boston

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06094257·Recruiting·Listed Oct 2023

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Genetic Testing Decision Aid

for Epithelial Ovarian Carcinoma

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05470920·Recruiting·Listed Jul 2022

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Brain Connectivity in Depression

for Depression

4 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT03276793·Recruiting·Listed Sep 2017

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Pain Disengagement Training (Open Pilot)

for Chronic Musculoskeletal Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06870162·Recruiting·Listed Mar 2025

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Estrogen Administration for the Treatment of NASH in Postmenopausal Women

for NASH - Nonalcoholic Steatohepatitis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 45 - 70

Code: NCT04833140·Phase 3·Recruiting·Listed Apr 2021

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HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease

for Cirrhosis

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05205954·Recruiting·Listed Jan 2022

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LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease

for Liver Disease Chronic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05998330·Recruiting·Listed Aug 2023

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Health Opportunities and Promoters of Equitable Screening for Lung Cancer

for Lung Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 80

Code: NCT05784922·Recruiting·Listed Mar 2023

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Supplemental Oxygen in Pulmonary Embolism (SO-PE)

for Pulmonary Embolism

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05891886·EARLY_Phase 1·Recruiting·Listed Jun 2023

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OCT Vibrography for Biomechanical Properties of Tissues

for Cornea

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT05759780·Recruiting·Listed Mar 2023

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Efficacy and Safety of Leadless Pacemakers Versus Left Bundle Area Pacing - A Preliminary Exploration

for Pacemaker Implantation

2 locations incl. Naples

Sponsor: NCH Healthcare System, Inc. dba Naples Comprehensive Health and dba NCH

Sex: All·Age: 18+

Code: NCT06690333·Recruiting·Listed Nov 2024

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Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU

for Consciousness Disorders

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06568536·Recruiting·Listed Aug 2024

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A Retrospective and Prospective Natural History of Genetic Vasculopathies

for Multisystemic Smooth Muscle Dysfunction Syndrome

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 29 Days+

Code: NCT06552052·Recruiting·Listed Aug 2024

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An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer

for Rectal Cancer

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05914766·Recruiting·Listed Jun 2023

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Project 4: Ambulatory Biofeedback and Voice Therapy for Patients With Vocal Hyperfunction

for Voice Disorders

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT05970562·EARLY_Phase 1·Recruiting·Listed Aug 2023

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APPRAISE 2.0: Live Trial of the APPRAISE Trauma Decision Support System

for Wounds and Injuries

1 location in Boston

Sponsor: Andrew Tomas Reisner

Sex: All·Age: 18+

Code: NCT06121661·Phase 1·Recruiting·Listed Nov 2023

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Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

for Depressive Disorder, Major

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 25 - 50

Code: NCT06136546·Phase 2·Recruiting·Listed Nov 2023

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Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients

for Fibromyalgia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT06009159·Recruiting·Listed Aug 2023

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Testing the mHealth App Intervention for Nondaily Smokers "SiS4"

for Smoking Cessation

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06678243·Recruiting·Listed Nov 2024

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Behavioral Economics to Implement a Traffic Light Nutrition Ranking System: Study 2

for Food Insecurity

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT06298253·Recruiting·Listed Mar 2024

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Spastic Paraplegia - Centers of Excellence Research Network

for Hereditary Spastic Paraplegia

11 locations incl. Miami

Sponsor: Boston Children's Hospital

Sex: All·Age: All ages

Code: NCT06553976·Recruiting·Listed Aug 2024

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Foundational Programs to Combat Clinician Stress

for Burnout, Professional

6 locations incl. Boston

Sponsor: Lancaster General Hospital

Sex: All·Age: 25 - 70·Accepts healthy volunteers

Code: NCT07220421·Recruiting·Listed Oct 2025

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ART-Pro: Clinical Trial Evaluating Biparametric MRI and Advanced, Quantitative Diffusion MRI for Detection of Prostate Cancer

for Prostate Cancer

4 locations incl. San Diego

Sponsor: University of California, San Diego

Sex: Male·Age: 18+

Code: NCT06579417·Recruiting·Listed Aug 2024

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Cognitive Dysfunction in Chronic and Persistent Immune Thrombocytopenia

for Immune Thrombocytopenia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06817395·Recruiting·Listed Feb 2025

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Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects

for Multiple Sclerosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT04699747·Phase 1·Recruiting·Listed Jan 2021

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Intent of Surgery for IPMN

for Intraductal Papillary Mucinous Neoplasm

8 locations incl. Phoenix

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07216521·Recruiting·Listed Oct 2025

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Family Members At INcreased-risk for Developing Inflammatory Bowel Disease

for Inflammatory Bowel Disease (IBD)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14+·Accepts healthy volunteers

Code: NCT06655415·Recruiting·Listed Oct 2024

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Assessing Tenapanor as a Treatment of CF-related Constipation.

for Cystic Fibrosis

Drug: Tenapanor

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT06810167·Phase 3·Recruiting·Listed Feb 2025

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Longitudinal Early-onset Alzheimer's Disease Study Protocol

for Early Onset Alzheimer Disease

18 locations incl. Los Angeles

Sponsor: Indiana University

Sex: All·Age: 40 - 64·Accepts healthy volunteers

Code: NCT03507257·Recruiting·Listed Apr 2018

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DNA Analysis of Blood and Tissue from Patients with Lung Cancer

for Lung Cancer

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT00471978·Recruiting·Listed May 2007

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Molecular and Genetic Analysis of Lung Cancer

for Lung Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03029325·Recruiting·Listed Jan 2017

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Partners Calciphylaxis Biobank

for Calciphylaxis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03032835·Recruiting·Listed Jan 2017

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Effect of PRP, PPP, & BMAC on Functional Outcomes Following Hip Arthroscopy for Acetabular Labral Pathologies

for Acetabular Labrum Tear

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06003101·Phase 3·Recruiting·Listed Aug 2023

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Prostate Cancer Genetic Risk Evaluation and Screening Study

for Prostatic Neoplasm

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Male·Age: 35 - 74

Code: NCT05129605·Recruiting·Listed Nov 2021

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The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)

for Glioblastoma

2 locations incl. San Francisco

Sponsor: Jasper Gerritsen

Sex: All·Age: 18 - 90

Code: NCT06283927·Recruiting·Listed Feb 2024

Apply to this trial