Clinical Trials at Massachusetts General Hospital

As of September 2026, 602 paid clinical trials are recruiting at Massachusetts General Hospital, located at 55 FRUIT ST, CARDIOLOGY, GRB 800, MS 843, BOSTON, MA 02114-2621, phone (617) 724-1935 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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603 clinical trials at Massachusetts General Hospital

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Investigational Trial to Evaluate XC001 Delivered Via an Cardiac Catheter in Subjects With Chronic Angina.

for Refractory Angina

Sites in Boston +13 more locations

Sponsor: XyloCor Therapeutics, Inc.

Sex: All·Age: 18 - 85

Code: NCT07048808·Phase 2·Recruiting·Listed Jul 2025

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A Study of ASP2138 Given Before Surgery, Then Chemotherapy After Surgery, in People With Pancreatic Ductal Cancer

for Pancreatic Ductal Adenocarcinoma

Sites in Boston +2 more locations

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07024615·Phase 1·Recruiting·Listed Jun 2025

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Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

for Amyotrophic Lateral Sclerosis

Sites in Boston +2 more locations

Sponsor: Paradromics

Sex: All·Age: 22 - 75

Code: NCT07357428·Recruiting·Listed Jan 2026

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Open-label Extension Study to Evaluate Metreleptin in Patients With Partial Lipodystrophy

for Familial Partial Lipodystrophy

Sites in Boston +6 more locations

Sponsor: Chiesi Farmaceutici S.p.A.

Sex: All·Age: 13+

Code: NCT06679270·Phase 3·Recruiting·Listed Nov 2024

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Study of NMS-03305293 in Adult Patient With Relapsed Small Cell Lung Cancer

for Small Cell Lung Cancer

Sites in Boston +2 more locations

Sponsor: Nerviano Medical Sciences

Sex: All·Age: 18+

Code: NCT06931626·Phase 1·Recruiting·Listed Apr 2025

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Study Evaluating the Efficacy and Safety of Artesunate

for CMV Infection

Sites in Boston +1 more location

Sponsor: Amivas Inc.

Sex: All·Age: 18+

Code: NCT06853184·Phase 2·Recruiting·Listed Feb 2025

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Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

for Pancreatic Ductal Adenocarcinoma

Sites in Boston +8 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06562192·Phase 1·Recruiting·Listed Aug 2024

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Phase 1/2 Study to Evaluate EP0062 as Monotherapy and in Combination in Patients With Advanced or Metastatic AR+/HER-2-/ER+ Breast Cancer

for Hormone Receptor-positive Breast Cancer

Sites in Boston +5 more locations

Sponsor: Ellipses Pharma

Sex: Female·Age: 18+

Code: NCT05573126·Phase 1, Phase 2·Recruiting·Listed Oct 2022

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Safety and Effectiveness of the Orsiro Mission 48-mm Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

for Coronary Artery Disease

Sites in Boston +9 more locations

Sponsor: Teleflex

Sex: All·Age: 18+

Code: NCT06779630·Recruiting·Listed Jan 2025

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A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma

for Multiple Myeloma in Relapse

Sites in Boston +7 more locations

Sponsor: Kelonia Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07075185·Phase 1·Recruiting·Listed Jul 2025

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An Open-Label Exploratory Study of Fosigotifator in Participants With Vanishing White Matter Disease

for Vanishing White Matter Disease

Sites in Boston +2 more locations

Sponsor: Calico Life Sciences LLC

Sex: All·Age: 6 Months+

Code: NCT05757141·Phase 1, Phase 2·Recruiting·Listed Mar 2023

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KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

for Mitochondrial Diseases

Sites in Boston +2 more locations

Sponsor: Khondrion BV

Sex: All·Age: 18+

Code: NCT06451757·Phase 3·Recruiting·Listed Jun 2024

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Aptis PRUJ Prosthesis for the Treatment of Patients With Proximal Radial Ulna Joint Disorders.

for Arthritis

Sites in Boston +5 more locations

Sponsor: Aptis Medical

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT05796908·Recruiting·Listed Apr 2023

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Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

for Rheumatoid Arthritis

Sites in Boston +8 more locations

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT06201416·Phase 1·Recruiting·Listed Jan 2024

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Computer Guided Microwave Liver Ablation

for Hepatocellular Carcinoma (HCC)

Sites in Boston +1 more location

Sponsor: NE Scientific INC

Sex: All·Age: 18 - 90

Code: NCT07226869·Recruiting·Listed Nov 2025

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Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

for Biliary Tract Cancer

Sites in Boston +5 more locations

Sponsor: ModeX Therapeutics, An OPKO Health Company

Sex: All·Age: 18+

Code: NCT06239194·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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A Trial to Study if REGN5837 in Combination With Odronextamab is Safe for Adult Participants With Aggressive B-cell Non-Hodgkin Lymphomas

for B-cell Non-Hodgkins Lymphoma (B-NHL)

Drug: Odronextamab

Sites in Boston +8 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05685173·Phase 1·Recruiting·Listed Jan 2023

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Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

for Acquired Antithrombin Deficiency

Sites in Boston +8 more locations

Sponsor: Octapharma

Sex: All·Age: 18 - 85

Code: NCT06096116·Phase 3·Recruiting·Listed Oct 2023

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Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

for Solid Tumor, Adult

Sites in Boston +8 more locations

Sponsor: Vivace Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT04665206·Phase 1, Phase 2·Recruiting·Listed Dec 2020

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Brain Stimulation for Severe Depression

for Depression Severe

Sites in Boston +1 more location

Sponsor: Inner Cosmos Inc

Sex: All·Age: 21 - 80

Code: NCT05393622·Recruiting·Listed May 2022

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Enhancing Heart Allograft Function With the OCS Heart System Trial

for Heart Transplant

Sites in Boston +7 more locations

Sponsor: TransMedics

Sex: All·Age: 18+

Code: NCT07145515·Recruiting·Listed Aug 2025

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Study of BMS-986497 (ORM-6151) as a Monotherapy, in Double and Triple Combination With Azacitidine and Venetoclax in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Boston +5 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06419634·Phase 1·Recruiting·Listed May 2024

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SNV4818 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +4 more locations

Sponsor: Pikavation Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06736704·Phase 1, Phase 2·Recruiting·Listed Dec 2024

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Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Boston +3 more locations

Sponsor: Ankyra Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06171750·Phase 1·Recruiting·Listed Dec 2023

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A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers

for Epithelial Ovarian Cancer

Sites in Boston +4 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06469281·Phase 1·Recruiting·Listed Jun 2024

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Study to Assess Safety, Efficacy and Persistence of ACE1831, in Subjects With IgG4-Related Disease

for IgG4 Related Disease

Sites in Boston +1 more location

Sponsor: Acepodia Biotech, Inc.

Sex: All·Age: 18 - 75

Code: NCT07061938·Phase 1, Phase 2·Recruiting·Listed Jul 2025

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Dose Escalation and Expansion Study of HM16390 Alone or With Pembrolizumab in Advanced or Metastatic Solid Tumors

for Advanced or Metastatic Solid Tumors

Sites in Boston +1 more location

Sponsor: Hanmi Pharmaceutical Company Limited

Sex: All·Age: 18+

Code: NCT06724016·Phase 1·Recruiting·Listed Dec 2024

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Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder

for Neuromyelitis Optica Spectrum Disorder

Drug: Inebilizumab

Sites in Boston +3 more locations

Sponsor: Amgen

Sex: All·Age: 2 - 17

Code: NCT05549258·Phase 2·Recruiting·Listed Sep 2022

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A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCs

for Triple Negative Breast Cancer

Sites in Boston +5 more locations

Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.

Sex: All·Age: 18+

Code: NCT06908928·Phase 1·Recruiting·Listed Apr 2025

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Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone

for Peripheral Arterial Diseases

Sites in Boston +8 more locations

Sponsor: Angiodynamics, Inc.

Sex: All·Age: All ages

Code: NCT06777901·Phase 4·Recruiting·Listed Jan 2025

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Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers

for Colorectal Cancer

1 location in Boston

Sponsor: Lumicell, Inc.

Sex: All·Age: 18+

Code: NCT02584244·Phase 1, Phase 2·Recruiting·Listed Oct 2015

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Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of TGW101 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +6 more locations

Sponsor: Tagworks Pharmaceuticals BV

Sex: All·Age: 18+

Code: NCT06959706·Phase 1·Recruiting·Listed May 2025

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A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

for Solid Tumor

Sites in Boston +4 more locations

Sponsor: ImmVira Pharma Co. Ltd

Sex: All·Age: 18+

Code: NCT04370587·Phase 1, Phase 2·Recruiting·Listed May 2020

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US Benchmarking Clinical Study

for HFpEF - Heart Failure With Preserved Ejection Fraction

3 locations in Boston

Sponsor: eMyosound SAS

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07215715·Recruiting·Listed Oct 2025

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Post-Market Clinical Investigation Plan- Collagen Dural Regeneration Matrix (DuraMatrix-Onlay Plus)

for Repair of Dura Mater

Sites in Boston +1 more location

Sponsor: Collagen Matrix

Sex: All·Age: 18+

Code: NCT06802133·Recruiting·Listed Jan 2025

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RAPA-501 Therapy for ALS

for Amyotrophic Lateral Sclerosis

1 location in Boston

Sponsor: Rapa Therapeutics LLC

Sex: All·Age: 18+

Code: NCT04220190·Phase 2, Phase 3·Recruiting·Listed Jan 2020

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Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

for Cancer

Sites in Boston +5 more locations

Sponsor: Simcha IL-18, Inc.

Sex: All·Age: 18+

Code: NCT04787042·Phase 1, Phase 2·Recruiting·Listed Mar 2021

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Study of REM-422 in Patients With AML or Higher Risk MDS

for Myelodysplastic Syndromes

Sites in Boston +4 more locations

Sponsor: Remix Therapeutics

Sex: All·Age: 18+

Code: NCT06297941·Phase 1·Recruiting·Listed Mar 2024

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Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment

for Cardiac Resynchronization Therapy

Sites in Boston +3 more locations

Sponsor: XSpline S.p.A.

Sex: All·Age: 18+

Code: NCT05327062·Recruiting·Listed Apr 2022

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Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

for Colorectal Neoplasms

Sites in Boston, Worcester +4 more locations

Sponsor: Surgimab

Sex: All·Age: 18+

Code: NCT03659448·Phase 3·Recruiting·Listed Sep 2018

Apply to this trial