Clinical Trials at Massachusetts General Hospital

As of July 2026, 599 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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604 clinical trials at Massachusetts General Hospital

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KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

for Mitochondrial Diseases

3 locations incl. Boston

Sponsor: Khondrion BV

Sex: All·Age: 18+

Code: NCT06451757·Phase 3·Recruiting·Listed Jun 2024

Apply to this trial

Safety and Effectiveness of the Orsiro Mission 48-mm Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

for Coronary Artery Disease

9 locations incl. Concord

Sponsor: Teleflex

Sex: All·Age: 18+

Code: NCT06779630·Recruiting·Listed Jan 2025

Apply to this trial

Aptis PRUJ Prosthesis for the Treatment of Patients With Proximal Radial Ulna Joint Disorders.

for Arthritis

7 locations incl. Carmel

Sponsor: Aptis Medical

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT05796908·Recruiting·Listed Apr 2023

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A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma

for Multiple Myeloma in Relapse

7 locations incl. Duarte

Sponsor: Kelonia Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07075185·Phase 1·Recruiting·Listed Jul 2025

Apply to this trial

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

for Biliary Tract Cancer

6 locations incl. Denver

Sponsor: ModeX Therapeutics, An OPKO Health Company

Sex: All·Age: 18+

Code: NCT06239194·Phase 1, Phase 2·Recruiting·Listed Feb 2024

Apply to this trial

Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

for Rheumatoid Arthritis

9 locations incl. Scottsdale

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT06201416·Phase 1·Recruiting·Listed Jan 2024

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Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

for Small Cell Lung Carcinoma

4 locations incl. Iowa City

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT07006727·Phase 1·Recruiting·Listed Jun 2025

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Study Evaluating the Efficacy and Safety of Artesunate

for CMV Infection

2 locations incl. Boston

Sponsor: Amivas Inc.

Sex: All·Age: 18+

Code: NCT06853184·Phase 2·Recruiting·Listed Feb 2025

Apply to this trial

Advanta VXT and Flixene PMCF Registry

for Peripheral Arterial Disease

1 location in Boston

Sponsor: Atrium Medical Corporation

Sex: All·Age: 18+

Code: NCT07161583·Recruiting·Listed Sep 2025

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A Trial to Study if REGN5837 in Combination With Odronextamab is Safe for Adult Participants With Aggressive B-cell Non-Hodgkin Lymphomas

for B-cell Non-Hodgkins Lymphoma (B-NHL)

Drug: Odronextamab

9 locations incl. Duarte

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05685173·Phase 1·Recruiting·Listed Jan 2023

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Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

for Acquired Antithrombin Deficiency

9 locations incl. Stanford

Sponsor: Octapharma

Sex: All·Age: 18 - 85

Code: NCT06096116·Phase 3·Recruiting·Listed Oct 2023

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FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer

for Breast Cancer

8 locations incl. La Jolla

Sponsor: Regor Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05304962·Phase 1·Recruiting·Listed Mar 2022

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Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

for Solid Tumor, Adult

9 locations incl. San Francisco

Sponsor: Vivace Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT04665206·Phase 1, Phase 2·Recruiting·Listed Dec 2020

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Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of TGW101 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

7 locations incl. Scottsdale

Sponsor: Tagworks Pharmaceuticals BV

Sex: All·Age: 18+

Code: NCT06959706·Phase 1·Recruiting·Listed May 2025

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PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717

for Prion Disease

3 locations incl. Boston

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06153966·Phase 1, Phase 2·Recruiting·Listed Dec 2023

Apply to this trial

Enhancing Heart Allograft Function With the OCS Heart System Trial

for Heart Transplant

8 locations incl. San Francisco

Sponsor: TransMedics

Sex: All·Age: 18+

Code: NCT07145515·Recruiting·Listed Aug 2025

Apply to this trial

Brain Stimulation for Severe Depression

for Depression Severe

2 locations incl. Boston

Sponsor: Inner Cosmos Inc

Sex: All·Age: 21 - 80

Code: NCT05393622·Recruiting·Listed May 2022

Apply to this trial

Study of BMS-986497 (ORM-6151) as a Monotherapy, in Double and Triple Combination With Azacitidine and Venetoclax in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

for Acute Myeloid Leukemia

Drug: Venetoclax

9 locations incl. New Haven

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06419634·Phase 1·Recruiting·Listed May 2024

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ARC101 in Advanced Solid Tumors

for Advanced Solid Tumor

3 locations incl. Boston

Sponsor: Third Arc Bio

Sex: All·Age: 18+

Code: NCT06672185·Phase 1·Recruiting·Listed Nov 2024

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SNV4818 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

5 locations incl. Los Angeles

Sponsor: Pikavation Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06736704·Phase 1, Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

US Benchmarking Clinical Study

for HFpEF - Heart Failure With Preserved Ejection Fraction

3 locations incl. Boston

Sponsor: eMyosound SAS

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07215715·Recruiting·Listed Oct 2025

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Study to Assess Safety, Efficacy and Persistence of ACE1831, in Subjects With IgG4-Related Disease

for IgG4 Related Disease

2 locations incl. Atlanta

Sponsor: Acepodia Biotech, Inc.

Sex: All·Age: 18 - 75

Code: NCT07061938·Phase 1, Phase 2·Recruiting·Listed Jul 2025

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Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

for Advanced Solid Tumor

4 locations incl. Bethesda

Sponsor: Ankyra Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06171750·Phase 1·Recruiting·Listed Dec 2023

Apply to this trial

Open-label Extension Study to Evaluate Metreleptin in Patients With Partial Lipodystrophy

for Familial Partial Lipodystrophy

7 locations incl. Birmingham

Sponsor: Amryt Pharma

Sex: All·Age: 13+

Code: NCT06679270·Phase 3·Recruiting·Listed Nov 2024

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A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers

for Epithelial Ovarian Cancer

5 locations incl. Boston

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06469281·Phase 1·Recruiting·Listed Jun 2024

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Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE)

for Systemic Sclerosis (SSc)

6 locations incl. La Jolla

Sponsor: Zura Bio Inc

Sex: All·Age: 18 - 75

Code: NCT06843239·Phase 2·Recruiting·Listed Feb 2025

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A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCs

for Triple Negative Breast Cancer

6 locations incl. Duarte

Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.

Sex: All·Age: 18+

Code: NCT06908928·Phase 1·Recruiting·Listed Apr 2025

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Study of NMS-03305293 in Adult Patient With Relapsed Small Cell Lung Cancer

for Small Cell Lung Cancer

2 locations incl. Boston

Sponsor: Nerviano Medical Sciences

Sex: All·Age: 18+

Code: NCT06931626·Phase 1·Recruiting·Listed Apr 2025

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A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

for Solid Tumor

6 locations incl. Boston

Sponsor: ImmVira Pharma Co. Ltd

Sex: All·Age: 18+

Code: NCT04370587·Phase 1, Phase 2·Recruiting·Listed May 2020

Apply to this trial

Dose Escalation and Expansion Study of HM16390 Alone or With Pembrolizumab in Advanced or Metastatic Solid Tumors

for Advanced or Metastatic Solid Tumors

2 locations incl. Boston

Sponsor: Hanmi Pharmaceutical Company Limited

Sex: All·Age: 18+

Code: NCT06724016·Phase 1·Recruiting·Listed Dec 2024

Apply to this trial

Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone

for Peripheral Arterial Diseases

9 locations incl. Phoenix

Sponsor: Angiodynamics, Inc.

Sex: All·Age: All ages

Code: NCT06777901·Phase 4·Recruiting·Listed Jan 2025

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Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder

for Neuromyelitis Optica Spectrum Disorder

Drug: Inebilizumab

4 locations incl. La Jolla

Sponsor: Amgen

Sex: All·Age: 2 - 17

Code: NCT05549258·Phase 2·Recruiting·Listed Sep 2022

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A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy

for Cerebral Adrenoleukodystrophy (cALD)

Drug: Leriglitazone

6 locations incl. Palo Alto

Sponsor: Minoryx Therapeutics, S.L.

Sex: Male·Age: 18+

Code: NCT05819866·Phase 3·Recruiting·Listed Apr 2023

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Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers

for Colorectal Cancer

1 location in Boston

Sponsor: Lumicell, Inc.

Sex: All·Age: 18+

Code: NCT02584244·Phase 1, Phase 2·Recruiting·Listed Oct 2015

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Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations

for Locally Advanced Cholangiocarcinoma

4 locations incl. San Francisco

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT06160752·Phase 1·Recruiting·Listed Dec 2023

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Post-Market Clinical Investigation Plan- Collagen Dural Regeneration Matrix (DuraMatrix-Onlay Plus)

for Repair of Dura Mater

2 locations incl. Augusta

Sponsor: Collagen Matrix

Sex: All·Age: 18+

Code: NCT06802133·Recruiting·Listed Jan 2025

Apply to this trial

RAPA-501 Therapy for ALS

for Amyotrophic Lateral Sclerosis

1 location in Boston

Sponsor: Rapa Therapeutics LLC

Sex: All·Age: 18+

Code: NCT04220190·Phase 2, Phase 3·Recruiting·Listed Jan 2020

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Study of REM-422 in Patients With AML or Higher Risk MDS

for Myelodysplastic Syndromes

5 locations incl. Duarte

Sponsor: Remix Therapeutics

Sex: All·Age: 18+

Code: NCT06297941·Phase 1·Recruiting·Listed Mar 2024

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Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

for Cancer

6 locations incl. Scottsdale

Sponsor: Simcha IL-18, Inc.

Sex: All·Age: 18+

Code: NCT04787042·Phase 1, Phase 2·Recruiting·Listed Mar 2021

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Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment

for Cardiac Resynchronization Therapy

4 locations incl. Chicago

Sponsor: XSpline S.p.A.

Sex: All·Age: 18+

Code: NCT05327062·Recruiting·Listed Apr 2022

Apply to this trial