Clinical Trials at Massachusetts General Hospital

As of September 2026, 602 paid clinical trials are recruiting at Massachusetts General Hospital, located at 55 FRUIT ST, CARDIOLOGY, GRB 800, MS 843, BOSTON, MA 02114-2621, phone (617) 724-1935 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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603 clinical trials at Massachusetts General Hospital

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Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

for Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS)

Sites in Boston +8 more locations

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT06465953·Phase 3·Recruiting·Listed Jun 2024

Apply to this trial

Zanubrutinib, Bendamustine, Rituximab Prev. Untreated WM

for Waldenstrom Macroglobulinemia

Drug: Rituximab

Sites in Boston +4 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06561347·Phase 2·Recruiting·Listed Aug 2024

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Elranatamab in R/R Multiple Myeloma

for Refractory Multiple Myeloma

Drug: Elranatamab

3 locations in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06138275·Phase 2·Recruiting·Listed Nov 2023

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A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

for Glioblastoma

Sites in Boston +20 more locations

Sponsor: Global Coalition for Adaptive Research

Sex: All·Age: 18+

Code: NCT03970447·Phase 2, Phase 3·Recruiting·Listed May 2019

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Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)

for Neurofibromatosis Type 2

Sites in Boston +5 more locations

Sponsor: Scott R. Plotkin, MD, PhD

Sex: All·Age: 12+

Code: NCT04374305·Phase 2·Recruiting·Listed May 2020

Apply to this trial

Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT)

for Status Epilepticus

Sites in Boston +61 more locations

Sponsor: University of Virginia

Sex: All·Age: 1+

Code: NCT06907173·Phase 3·Recruiting·Listed Apr 2025

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Tofersen in Non-SOD1 ALS

for ALS (Amyotrophic Lateral Sclerosis)

Sites in Boston +2 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07294144·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients

for Sensation Disorders

Sites in Boston +1 more location

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06094257·Recruiting·Listed Oct 2023

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Pemigatinib + Afatinib in Advanced Refractory Solid Tumors

for Advanced Solid Tumor

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06302621·Phase 1·Recruiting·Listed Mar 2024

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From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects

for Chronic Pain

3 locations in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT05661903·Phase 2·Recruiting·Listed Dec 2022

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INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

for Glioblastoma

Sites in Boston +3 more locations

Sponsor: David Reardon, MD

Sex: All·Age: 18+

Code: NCT02977780·Phase 2·Recruiting·Listed Nov 2016

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ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

Sites in Boston +24 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting·Listed Apr 2020

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Incremental Hemodialysis: The TwoPlus Trial

for End-Stage Kidney Disease

Sites in Boston +9 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05828823·Recruiting·Listed Apr 2023

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Partners Calciphylaxis Biobank

for Calciphylaxis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03032835·Recruiting·Listed Jan 2017

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Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

for Advanced Ovarian Carcinoma

Sites in Boston +11 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT04575935·Phase 3·Recruiting·Listed Oct 2020

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Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients

for Fibromyalgia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT06009159·Recruiting·Listed Aug 2023

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Vaginal Microbiota Transplant

for Recurrent Bacterial Vaginosis

1 location in Boston

Sponsor: Douglas Kwon

Sex: Female·Age: 18 - 50

Code: NCT04046900·Phase 1, Phase 2·Recruiting·Listed Aug 2019

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Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia

for Hypertension

2 locations in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 65

Code: NCT07238400·Phase 2·Recruiting·Listed Nov 2025

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Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study

for Chronic Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 120

Code: NCT07118722·Recruiting·Listed Aug 2025

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Project 4: Ambulatory Biofeedback and Voice Therapy for Patients With Vocal Hyperfunction

for Voice Disorders

2 locations in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT05970562·EARLY_Phase 1·Recruiting·Listed Aug 2023

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Dapagliflozin in Active Lupus Nephritis

for Lupus Nephritis (LN)

Drug: Dapagliflozin

2 locations in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70

Code: NCT07323524·Phase 4·Recruiting·Listed Jan 2026

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Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA

for Stomach Cancer Stage IV

Drug: Ivonescimab

Sites in Boston +1 more location

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07070466·Phase 2·Recruiting·Listed Jul 2025

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Subcortical Arousal in Perceptual Awareness

for Epilepsy

Sites in Boston +7 more locations

Sponsor: Yale University

Sex: All·Age: 13+

Code: NCT06934356·Recruiting·Listed Apr 2025

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Boston +112 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

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Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

for Alzheimer's Disease

Sites in Boston +1 more location

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 120

Code: NCT05658913·Recruiting·Listed Dec 2022

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Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

for Breast Cancer

Sites in Boston, Wellesley Hills +9 more locations

Sponsor: American College of Radiology

Sex: Female·Age: 45 - 74·Accepts healthy volunteers

Code: NCT05625659·Recruiting·Listed Nov 2022

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Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF

for Atrial Fibrillation

Sites in Boston +4 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT06099730·Recruiting·Listed Oct 2023

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Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea

for Hypothalamic Amenorrhea

1 location in Boston

Sponsor: Stephanie B. Seminara, MD

Sex: Female·Age: 18 - 45

Code: NCT07224438·Phase 2·Recruiting·Listed Nov 2025

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Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease

for Reproductive Disorder

1 location in Boston

Sponsor: Stephanie B. Seminara, MD

Sex: All·Age: 18 - 60

Code: NCT07224490·Phase 1·Recruiting·Listed Nov 2025

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A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia

for Hypertensive Disorder of Pregnancy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07312227·Recruiting·Listed Dec 2025

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Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

for Acute Respiratory Distress Syndrome

Sites in Boston, Lowell +31 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06066502·Phase 3·Recruiting·Listed Oct 2023

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Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

for Brain Tumor

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03286335·Recruiting·Listed Sep 2017

Apply to this trial

Pain Disengagement Training (Open Pilot)

for Chronic Musculoskeletal Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06870162·Recruiting·Listed Mar 2025

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Proton or Photon RT for Retroperitoneal Sarcomas

for Retroperitoneal Sarcoma

Sites in Boston +9 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT01659203·Phase 1, Phase 2·Recruiting·Listed Aug 2012

Apply to this trial

MOLAR: Mapping Oral Health and Local Area Resources

for Dental Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 1+

Code: NCT05688982·Recruiting·Listed Jan 2023

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PDT For Induction Therapy For Head And Neck Cancer

for Squamous Cell Carcinoma

2 locations in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07214987·Phase 2·Recruiting·Listed Oct 2025

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Zanubrutinib, Obinutuzumab, Sonrotoclax (BOSon) or BGB-16673, Obinutuzumab, Sonrotoclax (DOSon) in TN CLL/SLL

for Chronic Lymphocytic Leukemia

Drug: Sonrotoclax

Sites in Boston +1 more location

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06849713·Phase 2·Recruiting·Listed Feb 2025

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DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

for Gestational Diabetes Mellitus

Sites in Boston +20 more locations

Sponsor: Ohio State University

Sex: Female·Age: 18+

Code: NCT06445946·Phase 4·Recruiting·Listed Jun 2024

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Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

for Infant, Extremely Premature

Sites in Boston +42 more locations

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 0 - 1

Code: NCT05685745·Recruiting·Listed Jan 2023

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SAVE-Care (Sodium Glucose Cotransporter-2 Inhibitors [SGLT2i] As Novel Gout Care) Trial

for Gout and Hyperuricemia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT06674109·Phase 4·Recruiting·Listed Nov 2024

Apply to this trial