Clinical Trials at Massachusetts General Hospital

As of July 2026, 599 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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604 clinical trials at Massachusetts General Hospital

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Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

for Multiple Sclerosis

13 locations incl. New Haven

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55

Code: NCT05285891·Phase 4·Recruiting·Listed Mar 2022

Apply to this trial

Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

for Hiv

18 locations incl. Birmingham

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT06263426·Recruiting·Listed Feb 2024

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Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)

for Delirium

14 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 60+

Code: NCT06192615·Phase 3·Recruiting·Listed Jan 2024

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Bionic Pancreas in CFRD

for Cystic Fibrosis-related Diabetes

16 locations incl. Aurora

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 14+

Code: NCT06449677·Phase 3·Recruiting·Listed Jun 2024

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Global Prospective, Observational Cohort of Adult Patients With Primary Sclerosing Cholangitis (WIND-PSC Study)

for PSC

11 locations incl. Sacramento

Sponsor: PSC Partners Seeking a Cure

Sex: All·Age: 18 - 75

Code: NCT06297993·Recruiting·Listed Mar 2024

Apply to this trial

EQUAL: EGFR ctDNA QUantative Assessment for Lung Cancer Screening in Asian and Latinx Populations

for Lung Cancer

6 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 40 - 80·Accepts healthy volunteers

Code: NCT06716580·Recruiting·Listed Dec 2024

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Botensilimab, Balstilimab, and SBRT in Colorectal Cancer

for Non-MSI-H or pMMR Colorectal Cancer With Liver Metastasis

Drug: Botensilimab

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07128355·EARLY_Phase 1·Recruiting·Listed Aug 2025

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Nutrition for Precision Health, Powered by the All of Us

for Nutrition

14 locations incl. Birmingham

Sponsor: RTI International

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05701657·Recruiting·Listed Jan 2023

Apply to this trial

Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF

for Atrial Fibrillation

6 locations incl. Jonesboro

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT06099730·Recruiting·Listed Oct 2023

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Implementing Depression and Adherence Treatment

for Depression

2 locations incl. Miami

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT07032363·Recruiting·Listed Jun 2025

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Genetic and Environmental Risk Factors for Hemorrhagic Stroke

for Stroke

7 locations incl. Chicago

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00682695·Recruiting·Listed May 2008

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Subcortical Arousal in Perceptual Awareness

for Epilepsy

8 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 13+

Code: NCT06934356·Recruiting·Listed Apr 2025

Apply to this trial

TSC Biosample Repository and Natural History Database

for Tuberous Sclerosis

24 locations incl. Birmingham

Sponsor: National Tuberous Sclerosis Association

Sex: All·Age: All ages

Code: NCT05676099·Recruiting·Listed Jan 2023

Apply to this trial

Longitudinal Study of the Porphyrias

for Acute Porphyrias

16 locations incl. Birmingham

Sponsor: The American Porphyrias Expert Collaborative

Sex: All·Age: 1 Minute+

Code: NCT01561157·Recruiting·Listed Mar 2012

Apply to this trial

Incremental Hemodialysis: The TwoPlus Trial

for End-Stage Kidney Disease

10 locations incl. Jacksonville

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05828823·Recruiting·Listed Apr 2023

Apply to this trial

A One-Arm Open Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior

for Suicide Attempt

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06967545·Recruiting·Listed May 2025

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Finding Links Between Hot flASHes and CardioVascular Disease

for Menopause-related Hot Flashes

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 40 - 65

Code: NCT07077395·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

Zanubrutinib, Bendamustine, Rituximab Prev. Untreated WM

for Waldenstrom Macroglobulinemia

Drug: Rituximab

5 locations incl. Denver

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06561347·Phase 2·Recruiting·Listed Aug 2024

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Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

for PTSD

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07260032·Recruiting·Listed Dec 2025

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Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery

for Type 1 Diabetes (T1D)

2 locations incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT07011147·Recruiting·Listed Jun 2025

Apply to this trial

Sacituzumab Govitecan In TNBC

for Invasive Breast Cancer

5 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04230109·Phase 2·Recruiting·Listed Jan 2020

Apply to this trial

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia

for Anarthria

2 locations incl. Stanford

Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All·Age: 18 - 80

Code: NCT05724173·Recruiting·Listed Feb 2023

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BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

for Tetraplegia

6 locations incl. Sacramento

Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All·Age: 18 - 80

Code: NCT00912041·Recruiting·Listed Jun 2009

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Cognitive Rehabilitation for Victims of War and Related Traumas With Traumatic Brain Injury and Cognitive Impairment

for TBI (Traumatic Brain Injury)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT06839079·Recruiting·Listed Feb 2025

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Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation

for Infusion Reactions

71 locations incl. Birmingham

Sponsor: New York Blood Center

Sex: All·Age: All ages

Code: NCT01656603·Phase 2·Recruiting·Listed Aug 2012

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Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs

for HIV

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07199335·Phase 4·Recruiting·Listed Sep 2025

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IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

for Type B Aortic Dissection

61 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06087029·Recruiting·Listed Oct 2023

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Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

for Hypertension

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT06557005·Recruiting·Listed Aug 2024

Apply to this trial

Mobile Application to Improve Health-Related Outcomes in Patients With Advanced Lung Cancer

for Lung Cancer

3 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06427954·Recruiting·Listed May 2024

Apply to this trial

Thoracoabdominal Asynchrony and Respiratory Distress

for Respiratory Insufficiency

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 28 Days - 17

Code: NCT04626154·Recruiting·Listed Nov 2020

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Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms

for Normal Physiology

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT05829044·Recruiting·Listed Apr 2023

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Kisspeptin Administration Subcutaneously to Patients With IHH

for Hypogonadotropic Hypogonadism

1 location in Boston

Sponsor: Stephanie B. Seminara, MD

Sex: All·Age: 18+

Code: NCT05896293·Phase 2·Recruiting·Listed Jun 2023

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A Novel Approach to Upper Extremity Amputation to Augment Volitional Control and Restore Proprioception

for Amputation

4 locations incl. Bethesda

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT03882073·Recruiting·Listed Mar 2019

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GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH

for Genetic Predisposition

Drug: Semaglutide

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06003153·Phase 4·Recruiting·Listed Aug 2023

Apply to this trial

Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy

for Pediatric Patients Treated With Radiation Therapy

24 locations incl. Palo Alto

Sponsor: Massachusetts General Hospital

Sex: All·Age: Up to 21

Code: NCT01696721·Recruiting·Listed Oct 2012

Apply to this trial

Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline

for Chronic Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50+

Code: NCT06246929·Recruiting·Listed Feb 2024

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Tolerance Through Mixed Chimerism (Sip-Tego)

for Kidney Failure

1 location in Boston

Sponsor: Tatsuo Kawai, MD, PhD

Sex: All·Age: 18 - 65

Code: NCT06972069·EARLY_Phase 1·Recruiting·Listed May 2025

Apply to this trial

Pancreatic Cancer Early Detection Consortium

for Pancreas Cancer

45 locations incl. Phoenix

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04970056·Recruiting·Listed Jul 2021

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Well-being in IBS: Strengths and Happiness (WISH) 2.0

for Irritable Bowel Syndrome

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06866106·Recruiting·Listed Mar 2025

Apply to this trial

Voice Therapy Per the Rehabilitation Treatment Specification System

for Muscle Tension Dysphonia

5 locations incl. Atlanta

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14+

Code: NCT06152627·Recruiting·Listed Nov 2023

Apply to this trial