Clinical Trials at Massachusetts General Hospital

As of July 2026, 599 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 16, 2026.

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604 clinical trials at Massachusetts General Hospital

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Extended vs Short-term Abatacept Dosing for Graft Versus Host Disease Prophylaxis

for Graft Vs Host Disease

15 locations incl. Atlanta

Sponsor: Boston Children's Hospital

Sex: All·Age: 2+

Code: NCT04380740·Phase 2·Recruiting·Listed May 2020

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Development and Testing of a Mobile App to Scale Delivery of Cognitive-behavioral Therapy for Avoidant/Restrictive Food Intake Disorder

for Avoidant/Restrictive Food Intake Disorder (ARFID)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 55

Code: NCT06898177·Recruiting·Listed Mar 2025

Apply to this trial

Oxytocin for Weight Loss in Adolescents

for Obesity, Adolescent

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 10 - 18

Code: NCT04551482·Phase 2·Recruiting·Listed Sep 2020

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Effectiveness and Implementation of a Clinician Decision Support System to Prevent Suicidal Behaviors

for Suicide

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05671133·Recruiting·Listed Jan 2023

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Ivosidenib as Post-HSCT Maintenance for AML

for IDH1 Mutation

6 locations incl. Atlanta

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT06707493·Phase 2·Recruiting·Listed Nov 2024

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Effects of IL-1 Beta Inhibition on Vascular Inflammation in TET2 Clonal Hematopoiesis

for Vascular Inflammation

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06691217·Phase 2·Recruiting·Listed Nov 2024

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Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People at Risk for Alzheimer's Disease

for Alzheimer Disease

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05776641·Recruiting·Listed Mar 2023

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ATEMPT 2.0: Adjuvant T-DM1 vs TH

for Breast Cancer

53 locations incl. San Francisco

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04893109·Phase 2·Recruiting·Listed May 2021

Apply to this trial

EVOC - EVs in Obesity and Cardiometabolic Disease

for Cardiovascular Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06408961·Recruiting·Listed May 2024

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Telerehabilitation In The Home After Stroke

for Stroke

27 locations incl. Downey

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 80

Code: NCT06682429·Recruiting·Listed Nov 2024

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Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT)

for Status Epilepticus

52 locations incl. Tucson

Sponsor: University of Virginia

Sex: All·Age: 1+

Code: NCT06907173·Phase 3·Recruiting·Listed Apr 2025

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Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

for Anxiety Disorders

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14 - 19

Code: NCT05962879·Recruiting·Listed Jul 2023

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PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

for Parkinson Disease

30 locations incl. Birmingham

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT04477785·Recruiting·Listed Jul 2020

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Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

for Depression - Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06878859·Recruiting·Listed Mar 2025

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SAVE-Care (Sodium Glucose Cotransporter-2 Inhibitors [SGLT2i] As Novel Gout Care) Trial

for Gout and Hyperuricemia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT06674109·Phase 4·Recruiting·Listed Nov 2024

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Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

for Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS)

9 locations incl. Denver

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT06465953·Phase 3·Recruiting·Listed Jun 2024

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Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

for Giant Cell Tumor of Bone

14 locations incl. Los Angeles

Sponsor: St. Louis University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03295981·Phase 3·Recruiting·Listed Sep 2017

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iNO300 Therapy in Critically Ill Patients With Pneumonia

for Critical Illness

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06950294·EARLY_Phase 1·Recruiting·Listed Apr 2025

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Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)

for Neurofibromatosis Type 2

6 locations incl. Los Angeles

Sponsor: Scott R. Plotkin, MD, PhD

Sex: All·Age: 12+

Code: NCT04374305·Phase 2·Recruiting·Listed May 2020

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The Role of Wearable Devices in Predicting and Detecting Complications and Adverse Events

for Recovery

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04824066·Recruiting·Listed Apr 2021

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Care in Multiple Sclerosis (MS)

for Multiple Sclerosis

6 locations incl. Birmingham

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07011914·Recruiting·Listed Jun 2025

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Zanubrutinib, Obinutuzumab, and Sonrotoclax in Previously Untreated Patients With CLL or SLL

for Chronic Lymphocytic Leukemia

Drug: Sonrotoclax

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06849713·Phase 2·Recruiting·Listed Feb 2025

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Blood Pressure Variability and Ischemic Stroke Outcome

for Acute Ischemic Stroke

3 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05756257·Recruiting·Listed Mar 2023

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Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV

for HIV-1-infection

2 locations incl. Aurora

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 80

Code: NCT06554717·Phase 2·Recruiting·Listed Aug 2024

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The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU

for Feeding Patterns

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04737200·Recruiting·Listed Feb 2021

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Mezigdomide and Talquetamab in Relapsed and Refractory Multiple Myeloma

for Relapsed Refractory Multiple Myeloma (RRMM)

Drug: Mezigdomide

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07032714·Phase 1·Recruiting·Listed Jun 2025

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Deep Learning Using Chest X-Rays to Identify High Risk Patients for Lung Cancer Screening CT

for Lung Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 77

Code: NCT06910956·Recruiting·Listed Apr 2025

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Evaluating the Efficacy of RELiZORB in Managing Exocrine Pancreatic Insufficiency in Tube-fed Pancreatitis Patients

for Exocrine Pancreatic Insufficiency (EPI)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06691893·Phase 3·Recruiting·Listed Nov 2024

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Pemigatinib + Afatinib in Advanced Refractory Solid Tumors

for Advanced Solid Tumor

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06302621·Phase 1·Recruiting·Listed Mar 2024

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Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT

for Tumor Surgery

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT02792270·Recruiting·Listed Jun 2016

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Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

for Prostate Carcinoma

8 locations incl. Duarte

Sponsor: University of Washington

Sex: Male·Age: 40+·Accepts healthy volunteers

Code: NCT04472338·Recruiting·Listed Jul 2020

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PDAC-PATHWAYS: A Digital Informational and Supportive Care App for Patients Initiating Neoadjuvant Therapy for Pancreatic Ductal Adenocarcinoma

for PDAC - Pancreatic Ductal Adenocarcinoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07047807·Recruiting·Listed Jul 2025

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Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients

for Insomnia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65+

Code: NCT06375265·Recruiting·Listed Apr 2024

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Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage

for Subarachnoid Hemorrhage, Aneurysmal

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT05103566·Recruiting·Listed Nov 2021

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Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients

for Orthopaedic Trauma

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 70

Code: NCT06201676·Phase 4·Recruiting·Listed Jan 2024

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Synergistic Gut-brain Axis Modulation Via Vagal Stimulation and Support Therapy in Functional Dyspepsia

for Functional Dyspepsia

1 location in Boston

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 65

Code: NCT06360900·Recruiting·Listed Apr 2024

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EIM Via the Myolex mScan as an ALS Biomarker

for Amyotrophic Lateral Sclerosis

6 locations incl. Phoenix

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06491732·Recruiting·Listed Jul 2024

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Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

for Drug Allergy

6 locations incl. Scottsdale

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 70

Code: NCT06406114·Phase 2·Recruiting·Listed May 2024

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Momelotinib During and After HCT in Myelofibrosis

for Myelofibrosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07104799·Phase 1·Recruiting·Listed Aug 2025

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A Global Study of the PETAL Consortium

for T-Cell and NK-Cell Neoplasm

10 locations incl. Duarte

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06067347·Recruiting·Listed Oct 2023

Apply to this trial