Paid Clinical Trials in California

California has 6,389 paid clinical trials enrolling now across cities including Los Angeles, San Francisco and San Diego. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in California include Stanford Medicine, UCLA Health and UCSF, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 24, 2026.

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5,291 clinical trials

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A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma

for B-Cell Non-Hodgkins Lymphoma

Drug: Glofitamab

Sites in Los Angeles, San Francisco +31 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06806033·Phase 2·Recruiting·Listed Feb 2025

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A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis

for Rheumatoid Arthritis

Sites in Torrance, Beverly Hills +54 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06972446·Phase 2·Recruiting·Listed May 2025

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A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults

for Episodic Migraine

Sites in San Diego, La Jolla +66 more locations

Sponsor: Ipsen

Sex: All·Age: 18 - 80

Code: NCT06625060·Phase 2·Recruiting·Listed Oct 2024

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This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

for Non-Small Cell Lung Cancer

Drug: sigvotatug vedotin

Sites in Fullerton +74 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT06758401·Phase 3·Recruiting·Listed Jan 2025

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Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

for Breast Neoplasms

Sites in Santa Monica, Loma Linda +37 more locations

Sponsor: Natera, Inc.

Sex: All·Age: 18+

Code: NCT07214532·Recruiting·Listed Oct 2025

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Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy

for Urothelial Cancer

Sites in San Francisco, Palo Alto +31 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07106762·Phase 2, Phase 3·Recruiting·Listed Aug 2025

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A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

for Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer

Drug: Giredestrant

Sites in Los Angeles, Newport Beach +52 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06065748·Phase 3·Recruiting·Listed Oct 2023

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Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)

for Neovascular Age-related Macular Degeneration

Drug: Surabgene Lomparvovec

Sites in San Francisco, Sacramento +49 more locations

Sponsor: AbbVie

Sex: All·Age: 50+

Code: NCT07007065·Phase 3·Recruiting·Listed Jun 2025

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A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

for Diabetes Mellitus, Type 2

Sites in Palo Alto, La Jolla +121 more locations

Sponsor: Cleerly, Inc.

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06112418·Recruiting·Listed Nov 2023

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A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

for COVID-19 Infection

Sites in San Diego, Sacramento +63 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07013474·Phase 3·Recruiting·Listed Jun 2025

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Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)

for Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Sites in Los Angeles, San Francisco +24 more locations

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 65

Code: NCT07161037·Phase 2·Recruiting·Listed Sep 2025

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A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

for Metastatic Castration-resistant Prostate Cancer (mCRPC)

Sites in Los Angeles, San Francisco +56 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06136650·Phase 3·Recruiting·Listed Nov 2023

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A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

for Chronic Lymphocytic Leukemia

Sites in Los Angeles, Palo Alto +40 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06973187·Phase 3·Recruiting·Listed May 2025

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MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

for Lumbar Spinal Stenosis

Sites in Los Angeles, San Francisco +2341 more locations

Sponsor: Stryker Instruments

Sex: All·Age: 18+

Code: NCT03072927·Recruiting·Listed Mar 2017

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Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

for NSCLC (Non-small Cell Lung Cancer)

Drug: daraxonrasib

Sites in Long Beach +42 more locations

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06881784·Phase 3·Recruiting·Listed Mar 2025

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A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition

for Metabolic Dysfunction-Associated SteatoHepatitis (MASH)

Sites in Orange, Long Beach +35 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT05519475·Phase 2·Recruiting·Listed Aug 2022

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Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study

for Moderate Aortic Valve Stenosis

Drug: Ataciguat

Sites in Los Angeles, San Francisco +67 more locations

Sponsor: Kardigan, Inc.

Sex: All·Age: 50+

Code: NCT07001800·Phase 2, Phase 3·Recruiting·Listed Jun 2025

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A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

for Psoriatic Arthritis

Drug: Tirzepatide

Sites in San Diego, Santa Monica +51 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06864026·Phase 4·Recruiting·Listed Mar 2025

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A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

for Coronavirus Disease (COVID-19)

Sites in San Francisco, San Diego +59 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06667700·Phase 3·Recruiting·Listed Oct 2024

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A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo

for NonSegmental Vitiligo

Drug: Ruxolitinib

Sites in Los Angeles, San Diego +67 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 2 - 11

Code: NCT06548360·Phase 3·Recruiting·Listed Aug 2024

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A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

for Hidradenitis Suppurativa

Drug: Upadacitinib

Sites in Los Angeles, Sacramento +63 more locations

Sponsor: AbbVie

Sex: All·Age: 12+

Code: NCT05889182·Phase 3·Recruiting·Listed Jun 2023

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A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

for Ulcerative Colitis

Sites in Escondido, Murrieta +76 more locations

Sponsor: Takeda

Sex: All·Age: 18 - 80

Code: NCT06581328·Phase 4·Recruiting·Listed Sep 2024

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Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells

for Neoplasms

Sites in San Francisco, La Jolla +75 more locations

Sponsor: Celgene

Sex: All·Age: All ages

Code: NCT03435796·Phase 2, Phase 3·Recruiting·Listed Feb 2018

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A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease

for COVID-19 SARS-CoV-2 Infection

Sites in Los Angeles, San Diego +79 more locations

Sponsor: Pfizer

Sex: All·Age: 12+

Code: NCT06679140·Phase 3·Recruiting·Listed Nov 2024

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A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

for Endometrial Cancer

Sites in Orange, Irvine +44 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: Female·Age: 18+

Code: NCT06952504·Phase 3·Recruiting·Listed May 2025

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A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab

for Atopic Dermatitis

Drug: Upadacitinib

Sites in San Diego, Sacramento +64 more locations

Sponsor: AbbVie

Sex: All·Age: 18 - 63

Code: NCT06389136·Phase 3·Recruiting·Listed Apr 2024

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A Trial of the Efficacy and Safety of SEP-363856 in Acutely Psychotic Participants With Schizophrenia

for Schizophrenia

Sites in Bellflower, Sherman Oaks +11 more locations

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 18 - 65

Code: NCT06894212·Phase 3·Recruiting·Listed Mar 2025

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A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

for Chronic Lymphocytic Leukemia

Drug: Nemtabrutinib

Sites in La Jolla, Pasadena +41 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06136559·Phase 3·Recruiting·Listed Nov 2023

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A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

for Triple Negative Breast Neoplasms

Sites in Los Angeles, San Francisco +35 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06841354·Phase 3·Recruiting·Listed Feb 2025

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A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO

for Neovascular Age-Related Macular Degeneration (NVAMD)

Sites in Sacramento, Glendale +47 more locations

Sponsor: EyeBiotech Ltd.

Sex: All·Age: 18+

Code: NCT07205887·Phase 2·Recruiting·Listed Oct 2025

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Assessment of CCM in HF With Higher Ejection Fraction

for Heart Failure

Sites in Los Angeles, La Jolla +74 more locations

Sponsor: Impulse Dynamics

Sex: All·Age: 18+

Code: NCT05064709·Recruiting·Listed Oct 2021

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Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

for Acute Myeloid Leukemia (AML)

Sites in Los Angeles, La Jolla +40 more locations

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT07007312·Phase 3·Recruiting·Listed Jun 2025

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A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

for Ovarian Cancer

Drug: INCB123667

Sites in Los Angeles, San Diego +36 more locations

Sponsor: Incyte Corporation

Sex: Female·Age: 18 - 99

Code: NCT07023627·Phase 2·Recruiting·Listed Jun 2025

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A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer

for Breast Cancer

Sites in Los Angeles, Palo Alto +132 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT06966453·Phase 1, Phase 2·Recruiting·Listed May 2025

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Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

for Solid Tumors

Sites in Los Angeles, San Francisco +41 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT03486873·Phase 3·Recruiting·Listed Apr 2018

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Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease

for Alzheimer Disease

Sites in Orange, Oakland +37 more locations

Sponsor: Lighthouse Pharmaceuticals, Inc.

Sex: All·Age: 55 - 80

Code: NCT06847321·Phase 2·Recruiting·Listed Feb 2025

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A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose

for RSV Infection

Sites in Los Angeles, Palo Alto +79 more locations

Sponsor: Pfizer

Sex: All·Age: 0+·Accepts healthy volunteers

Code: NCT06866405·Phase 3·Recruiting·Listed Mar 2025

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A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

for Breast Cancer

Sites in Los Angeles, Palo Alto +52 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06790693·Phase 3·Recruiting·Listed Jan 2025

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A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

for Osteoarthritis, Knee

Sites in San Diego, Riverside +39 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT05986292·Phase 2·Recruiting·Listed Aug 2023

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A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

for Heart Failure

Drug: Empagliflozin

Sites in Orange, Chula Vista +93 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06424288·Phase 3·Recruiting·Listed May 2024

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