Oncology Clinical Trials in Chapel Hill, NC

As of July 2026, 164 paid clinical trials are recruiting for Oncology in Chapel Hill, North Carolina. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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169 clinical trials for Oncology

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A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

for AML (Acute Myelogenous Leukemia)

Sites in Chapel Hill +12 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: 18 - 66

Code: NCT06859424·Phase 2·Recruiting·Listed Mar 2025

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Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 50+

Code: NCT06902311·Phase 2·Recruiting·Listed Mar 2025

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Study of Trilaciclib and Lurbinectidin

for Lung Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05578326·Phase 2·Recruiting·Listed Oct 2022

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Disease Outcomes and Toxicities in Patients With Gastrointestinal and Sarcomatous Malignancies

for Sarcoma

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05743426·Recruiting·Listed Feb 2023

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Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma

for Neuroblastoma

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 Months+

Code: NCT03721068·Phase 1·Recruiting·Listed Oct 2018

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Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors

for Obesity

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 39

Code: NCT06848491·Recruiting·Listed Feb 2025

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Integrating Biological, Clinical, and Behavioral Factors to Improve Breast Cancer Outcomes - Carolina Breast Cancer Study

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 20 - 74

Code: NCT07214610·Recruiting·Listed Oct 2025

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Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma

for Pancreatic Ductal Adenocarcinoma

Sites in Chapel Hill +4 more locations

Sponsor: Gulam Manji

Sex: All·Age: 18+

Code: NCT06048484·Phase 2·Recruiting·Listed Sep 2023

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A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer

for Metastatic Breast Cancer

Sites in Chapel Hill +11 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06099769·Phase 2·Recruiting·Listed Oct 2023

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Rehabilitation Outcomes Study

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06674889·Recruiting·Listed Nov 2024

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Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07025785·Recruiting·Listed Jun 2025

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Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer

for Lung Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05620342·EARLY_Phase 1·Recruiting·Listed Nov 2022

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Harnessing Analysis RNA Expression and Molecular Subtype to Optimize Novel TherapY MBCA

for Breast Cancer

Sites in Chapel Hill & Raleigh

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99

Code: NCT03769415·Recruiting·Listed Dec 2018

Apply to this trial

ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer

for Endometrial Cancer

Drug: Atezolizumab

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT05542407·Phase 1·Recruiting·Listed Sep 2022

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Effectiveness of Central Oncology Navigation and the Use of an ORN

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06618274·Recruiting·Listed Oct 2024

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DISCOVERY: Evaluating a Decision Support Tool for Adults Seen in Hematology/Oncology Clinics

for Hematologic Malignancies

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 60+

Code: NCT06296368·Recruiting·Listed Mar 2024

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National Liver Cancer Screening Trial

for Carcinoma, Hepatocellular

Sites in Chapel Hill +17 more locations

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 85

Code: NCT06084234·Phase 4·Recruiting·Listed Oct 2023

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Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

for Barretts Esophagus With Dysplasia

Sites in Chapel Hill +22 more locations

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05753748·Recruiting·Listed Mar 2023

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Study of Kappa Chimeric Antigen Receptor (CAR) T Lymphocytes Co-Expressing the Kappa and CD28 CARs for Relapsed/Refractory Kappa+ Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

for Mantle Cell Lymphoma

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT04223765·Phase 1·Recruiting·Listed Jan 2020

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Medically Tailored Meals for Kids

for Pediatric Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 12 - 99

Code: NCT06814795·Recruiting·Listed Feb 2025

Apply to this trial

Multimedia Aid for Genetic Testing in Gynecologic Oncology

for Ovary Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT07084168·Recruiting·Listed Jul 2025

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Phase 2 Study of Glofitamab Monotherapy & With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation

for Chronic Lymphocytic Leukemia

Drug: Polatuzumab Vedotin

Sites in Chapel Hill +4 more locations

Sponsor: Christine Ryan

Sex: All·Age: 18+

Code: NCT06043674·Phase 2·Recruiting·Listed Sep 2023

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Abatacept in Immune Checkpoint Inhibitor Myocarditis

for Myocarditis Acute

Sites in Chapel Hill +28 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05335928·Phase 3·Recruiting·Listed Apr 2022

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Healthy Living Anson Study

for Obesity (Disorder)

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07126587·Recruiting·Listed Aug 2025

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Designing Visual Tools to Enhance Cancer Surgeon Decision-making

for Prostate Cancer

Sites in Chapel Hill & Wilmington

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06965192·Recruiting·Listed May 2025

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TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

for Breast Cancer

Sites in Chapel Hill +10 more locations

Sponsor: Ana C Garrido-Castro, MD

Sex: All·Age: 18+

Code: NCT06533826·Phase 2·Recruiting·Listed Aug 2024

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BREAST Choice Decision Tool R21 - AIM2

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06817226·Recruiting·Listed Feb 2025

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XL092 and Cemiplimab in BRAF WT Thyroid Cancer

for Anaplastic Thyroid Cancer

Drug: Cemiplimab

Sites in Chapel Hill +1 more location

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06902376·Phase 1·Recruiting·Listed Mar 2025

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Registry for Adults With Plasma Cell Disorders (PCD's)

for Multiple Myeloma

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT03717844·Recruiting·Listed Oct 2018

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Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

for Barrett Esophagus

Sites in Chapel Hill +4 more locations

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06687603·Recruiting·Listed Nov 2024

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Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer

for Chronic Myeloproliferative Disorders

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 120

Code: NCT01137643·Recruiting·Listed Jun 2010

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Young Adult Infusion Space Experience Satisfaction Survey

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 39

Code: NCT05720546·Recruiting·Listed Feb 2023

Apply to this trial

GRID Therapy for Extremity Soft Tissue Sarcoma

for Sarcoma

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06073067·Recruiting·Listed Oct 2023

Apply to this trial

UNC Pleural Fluid Registry

for Lung Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05620329·Recruiting·Listed Nov 2022

Apply to this trial

Digital Art Therapy for Young Cancer Survivors

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 25

Code: NCT06789666·Recruiting·Listed Jan 2025

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Comparison of CE-DBT and MRI in Patients With Known Breast Lesions

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT05754749·EARLY_Phase 1·Recruiting·Listed Mar 2023

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Evaluation of the Acceptability, Appropriateness, and Feasibility/Usability of a Metastatic Breast-cancer Specific Prognostic Calculator Among Clinicians

for Metastatic Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05440929·Recruiting·Listed Jul 2022

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Expanding the Support of Family Caregivers of Diverse Patients With Cancer and Diabetes

for Cancer

Sites in Chapel Hill +2 more locations

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07061652·Recruiting·Listed Jul 2025

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ATLCAR.CD30.CCR4 for CD30+ HL ATLCAR.CD30.CCR4 Cells

for Hodgkin Lymphoma

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06090864·Phase 1, Phase 2·Recruiting·Listed Oct 2023

Apply to this trial

Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors

for Tumor, Solid

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99

Code: NCT03454035·Phase 1·Recruiting·Listed Mar 2018

Apply to this trial

Conditions in Oncology (Chapel Hill, NC)

Breast cancer· 33 Cancer (any)· 19 Non-small cell lung cancer (NSCLC)· 16 Multiple myeloma· 16 Solid tumor· 15 Acute myeloid leukemia (AML)· 11 Lung cancer· 10 Non-Hodgkin lymphoma· 10 Pancreatic cancer· 9 Chronic lymphocytic leukemia (CLL)· 9 Leukemia (other)· 9 Metastatic breast cancer· 8 Head and neck cancer· 8 Esophageal cancer· 7 Small lymphocytic lymphoma· 7 Hematologic malignancy· 7 Ovarian cancer· 6 Endometrial cancer· 6 Myelodysplastic syndromes (MDS)· 6 Bladder cancer· 5 Triple-negative breast cancer· 4 Colorectal cancer· 4 Prostate cancer· 4 Follicular lymphoma· 4 Mantle cell lymphoma· 4 Melanoma· 4 Gastric cancer· 3 Kidney cancer· 3 Glioblastoma· 3 Acute lymphoblastic leukemia· 3 Myelofibrosis· 3 Marginal zone lymphoma· 3 Neuroblastoma· 3 Pediatric cancer· 3 HER2-negative breast cancer· 2 Cervical cancer· 2 Brain cancer· 2 Myeloproliferative neoplasm· 2 Hodgkin lymphoma· 2 Thyroid cancer· 2 Sarcoma· 2 Osteosarcoma· 2 Small cell lung cancer· 1 Metastatic colorectal cancer· 1 Colon cancer· 1 Gastroesophageal junction cancer· 1 Liver cancer· 1 Biliary tract cancer· 1 Gastrointestinal cancer· 1 Fallopian tube cancer· 1 Diffuse large B-cell lymphoma (DLBCL)· 1 Burkitt lymphoma· 1 Mesothelioma· 1 Neuroendocrine tumors· 1