Paid Clinical Trials in Chapel Hill, NC

As of August 2026, 700 paid clinical trials are recruiting in Chapel Hill, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 12, 2026.

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615 clinical trials

NEPTUNE Match Study

for Nephrotic Syndrome in Children

Sites in Chapel Hill +15 more locations

Sponsor: University of Michigan

Sex: All·Age: 1 - 80

Code: NCT04571658·Recruiting·Listed Oct 2020

Apply to this trial

Autologous CAR-T Cells Targeting B7-H3 in PDAC

for Pancreas Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06158139·Phase 1·Recruiting·Listed Dec 2023

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Open Versus Arthroscopic Stabilization of Shoulder Instability With Subcritical Bone Loss: The OASIS Trial

for Shoulder Dislocation

Sites in Chapel Hill, Durham +8 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 17 - 50

Code: NCT04809064·Recruiting·Listed Mar 2021

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Promoting Resilience in Women With Breast Cancer (PRISM -MBC)

for Breast Cancer

Sites in Chapel Hill +1 more location

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06855654·Recruiting·Listed Mar 2025

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The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study

for Toxicity

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT04700527·Phase 1, Phase 2·Recruiting·Listed Jan 2021

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Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

for Gonorrhea

Sites in Chapel Hill +12 more locations

Sponsor: Westat

Sex: Female·Age: 13 - 29

Code: NCT06738407·Phase 4·Recruiting·Listed Dec 2024

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Caring for the Carer

for Care Burden

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07167641·Recruiting·Listed Sep 2025

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VisR Ultrasound for Noninvasively Interrogating Stromal Collagen Organization in Women as a Breast Cancer Biomarker: Evaluation of Anisotropy in Cancer Patients

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 20 - 90

Code: NCT06878547·Recruiting·Listed Mar 2025

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Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

for Hypertensive Disorders of Pregnancy

Sites in Chapel Hill +15 more locations

Sponsor: Ohio State University

Sex: Female·Age: 14 - 35

Code: NCT06468202·Phase 4·Recruiting·Listed Jun 2024

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A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma

for Plasmablastic Lymphoma

Drug: Daratumumab

Sites in Chapel Hill +7 more locations

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT04139304·EARLY_Phase 1·Recruiting·Listed Oct 2019

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Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation After Lumpectomy

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 65+

Code: NCT05472792·Phase 2·Recruiting·Listed Jul 2022

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Transmission and Acquisition of Nontuberculous Mycobacteria Outbreak Investigation (TrANsMIt)

for Nontuberculous Mycobacterial Pulmonary Infection

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 1 Month - 99

Code: NCT06155747·Recruiting·Listed Dec 2023

Apply to this trial

Menopausal HT for Women Living With HIV (HoT)

for HIV Infection

Sites in Chapel Hill, Greensboro +21 more locations

Sponsor: Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Sex: Female·Age: 40 - 60

Code: NCT06856174·Phase 4·Recruiting·Listed Mar 2025

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Lupus Landmark Study: A Prospective Registry and Biorepository

for Systemic Lupus Erythematosus (SLE)

Sites in Chapel Hill +18 more locations

Sponsor: Lupus Research Alliance

Sex: All·Age: 18 - 110

Code: NCT05934149·Recruiting·Listed Jul 2023

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Autologous CAR-T Cells Targeting B7H3 in Ovarian Cancer iC9-CAR.B7-H3 T Cells

for Ovary Neoplasm

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT06305299·Phase 1·Recruiting·Listed Mar 2024

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Modulation of Brain Rhythms in Stroke

for Stroke

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 45 - 80

Code: NCT07121582·Recruiting·Listed Aug 2025

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Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases

for Metabolic Disorders

Sites in Chapel Hill +11 more locations

Sponsor: Washington University School of Medicine

Sex: All·Age: Up to 20

Code: NCT00920972·Phase 1, Phase 2·Recruiting·Listed Jun 2009

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Supraglottic Airway for Resuscitation Trial

for Neonatal Resuscitation

Sites in Chapel Hill, Charlotte +28 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 Days+

Code: NCT07150923·Recruiting·Listed Sep 2025

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Single Versus Dual Implant Fixation of Distal Femur Fractures

for Articular Fractures

Sites in Chapel Hill, Concord +14 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06286670·Recruiting·Listed Feb 2024

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Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

for Breast Cancer

Sites in Chapel Hill +14 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04468061·Phase 2·Recruiting·Listed Jul 2020

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Tirzepatide in Obesity-Driven Endometrial Cancer

for Endometrial Cancer

Drug: Tirzepatide

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT07065552·EARLY_Phase 1·Recruiting·Listed Jul 2025

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Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial

for Obstetrical Complications

Sites in Chapel Hill, Durham +12 more locations

Sponsor: The George Washington University Biostatistics Center

Sex: Female·Age: All ages·Accepts healthy volunteers

Code: NCT06605118·Phase 3·Recruiting·Listed Sep 2024

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Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial

for Preterm Delivery

Sites in Chapel Hill, Durham +12 more locations

Sponsor: The George Washington University Biostatistics Center

Sex: Female·Age: 14+·Accepts healthy volunteers

Code: NCT06980025·Phase 3·Recruiting·Listed May 2025

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SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

for Acute Myeloid Leukemia With FLT3/ITD Mutation

Sites in Chapel Hill +3 more locations

Sponsor: Uma Borate

Sex: All·Age: 18+

Code: NCT06222580·Phase 1·Recruiting·Listed Jan 2024

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Promoting CT Engagement for Pancreatic Cancer With App

for Pancreas Cancer

Sites in Chapel Hill +1 more location

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06252545·Recruiting·Listed Feb 2024

Apply to this trial

Blood and Urine HPVDNA as Minimally Invasive Biomarkers for Cervical Cancer Detection and Surveillance Following Treatment

for Cervical Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT04743674·Recruiting·Listed Feb 2021

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UNC Childhood, Adolescent, and Young Adult Cancer Cohort

for Pediatric Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 1 - 39

Code: NCT05096923·Recruiting·Listed Oct 2021

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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Chapel Hill, Hillsborough +913 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05929768·Phase 3·Recruiting·Listed Jul 2023

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Affect-based Impulsivity in Borderline Personality Disorder

for Borderline Personality Disorder (BPD)

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06880640·Recruiting·Listed Mar 2025

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PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07069595·Phase 2·Recruiting·Listed Jul 2025

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RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE

for Osteoporosis

Sites in Chapel Hill, Durham +21 more locations

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 50+

Code: NCT06455085·Recruiting·Listed Jun 2024

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Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT06727773·Phase 2·Recruiting·Listed Dec 2024

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Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

for Surgery

Sites in Chapel Hill +5 more locations

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT05722002·Phase 4·Recruiting·Listed Feb 2023

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UNC Metastatic Cancer Radiation Therapy Registry

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06306924·Recruiting·Listed Mar 2024

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

Sites in Chapel Hill, Durham +143 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017

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Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

for Schizophrenia

Sites in Chapel Hill +6 more locations

Sponsor: New York State Psychiatric Institute

Sex: All·Age: 18 - 65

Code: NCT05208190·Phase 4·Recruiting·Listed Jan 2022

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Woodsmoke Exposure, Influenza Infection, and Nasal Immunity

for Smoke Exposure

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 49·Accepts healthy volunteers

Code: NCT06841913·Phase 4·Recruiting·Listed Feb 2025

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Child-Adult Relationship Enhancement in Primary Care (PriCARE) / Criando Niños Con CARIÑO (CARIÑO)

for Parent-Child Relations

Sites in Chapel Hill +1 more location

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 Months - 99·Accepts healthy volunteers

Code: NCT05233150·Recruiting·Listed Feb 2022

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Kidney Precision Medicine Project

for Acute Kidney Failure

Sites in Chapel Hill +12 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04334707·Recruiting·Listed Apr 2020

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Examining the Effects of Estradiol on Neural and Molecular Response to Reward

for Depression

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 45 - 55

Code: NCT05282277·Phase 4·Recruiting·Listed Mar 2022

Apply to this trial