Paid Clinical Trials in Chapel Hill, NC

As of September 2026, 702 paid clinical trials are recruiting in Chapel Hill, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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613 clinical trials

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Preventing Suicidal Behavior With Diverse High-Risk Youth in Acute Care Settings

for Suicide, Attempted

Sites in Chapel Hill +5 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 12 - 24

Code: NCT06151158·Recruiting·Listed Nov 2023

Apply to this trial

A Decisional Intervention for Older Adults With Acute Myeloid Leukemia and Their Caregivers

for Oncology

Sites in Chapel Hill, Winston-Salem +2 more locations

Sponsor: University of Rochester

Sex: All·Age: 60+

Code: NCT06697600·Recruiting·Listed Nov 2024

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A Study of CyBorD (Cyclophosphamide, Bortezomib, Dexamethasone) Plus Daratumumab in People With Monoclonal Gammopathy of Renal Significance (MGRS)

for Multiple Myeloma

Drug: Daratumumab

Sites in Chapel Hill +8 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06083922·Phase 2·Recruiting·Listed Oct 2023

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Frontline T-cell Engager vs Autologous Stem Cell Transplant (ASCT) and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma

for Multiple Myeloma, Newly Diagnosed

Sites in Chapel Hill +9 more locations

Sponsor: SCRI Development Innovations, LLC

Sex: All·Age: 19+

Code: NCT06974786·Phase 2·Recruiting·Listed May 2025

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Apathy in Parkinson Disease TMS Study

for Parkinson Disease

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 55 - 80

Code: NCT06087926·Recruiting·Listed Oct 2023

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International Registry for Men With Advanced Prostate Cancer (IRONMAN)

for Prostate Cancer

Sites in Chapel Hill, Durham +33 more locations

Sponsor: Prostate Cancer Clinical Trials Consortium

Sex: Male·Age: 21+

Code: NCT03151629·Recruiting·Listed May 2017

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Combating Cancer-Related Fatigue: A Personalized Supportive Care Program

for Indolent Lymphomas

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06860880·Recruiting·Listed Mar 2025

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Pharmacokinetics of Off Label Pediatric Medications

for Off Label Use of Medications in Pediatric Patients

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 1 Day - 8

Code: NCT01286519·Recruiting·Listed Jan 2011

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Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease

for Kartagener Syndrome

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT00807482·Recruiting·Listed Dec 2008

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Registry of Older Patients With Cancer

for Chronic Myeloproliferative Disorders

Sites in Chapel Hill, Raleigh +5 more locations

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 65+

Code: NCT01137825·Recruiting·Listed Jun 2010

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Ultrasound for Evaluation of Percutaneous G-tube Position

for Gastrostomy

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: Up to 18

Code: NCT06361498·Recruiting·Listed Apr 2024

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Correlation of Molecular Markers With Response to Therapy and Breast Cancer Behavior

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT01000883·Recruiting·Listed Oct 2009

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Gait Rehabilitation to Treat FastOA

for Anterior Cruciate Ligament Injuries

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 16 - 35

Code: NCT05848622·Recruiting·Listed May 2023

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Targeted Motor Learning to Improve Gait for Individuals With Parkinson Disease

for Parkinson Disease

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 50 - 80

Code: NCT05864157·Recruiting·Listed May 2023

Apply to this trial

IDH Targeted/Non- Targeted vs Non-targeted/IDH-targeted Approaches in the Treatment of Newly Diagnosed IDH Mutated AML Patients Not Candidates for Intensive Induction Therapy (I- DATA Study)

for Acute Myeloid Leukemia

Sites in Chapel Hill +3 more locations

Sponsor: Alice Mims

Sex: All·Age: 18+

Code: NCT05401097·Phase 2·Recruiting·Listed Jun 2022

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Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

Sites in Chapel Hill, Durham +3 more locations

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05145400·Phase 2·Recruiting·Listed Dec 2021

Apply to this trial

mHealth for Early Psychosis Caregivers in Statewide Program Outreach

for Caregiver

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07225179·Recruiting·Listed Nov 2025

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Feasibility of Symptom Management for Patients With Metastatic Breast Cancer to Increase Exercise

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07313306·Recruiting·Listed Dec 2025

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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Chapel Hill, Hillsborough +913 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05929768·Phase 3·Recruiting·Listed Jul 2023

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Horizon Two: HR NDMM (MMRC-100)

for High Risk Newly Diagnosed Multiple Myeloma

Sites in Chapel Hill +6 more locations

Sponsor: Multiple Myeloma Research Consortium

Sex: All·Age: 18+

Code: NCT07053436·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

Sugary Drink Labeling Study

for Health Behavior

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07294053·Recruiting·Listed Dec 2025

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Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses

for Dentofacial Abnormalities

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 15 - 40

Code: NCT04117360·Recruiting·Listed Oct 2019

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Animal Assisted Therapy in Pediatric Dentistry

for Anxiety

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 4 - 8·Accepts healthy volunteers

Code: NCT05464888·Recruiting·Listed Jul 2022

Apply to this trial

Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy

for Pediatric Patients Treated With Radiation Therapy

Sites in Chapel Hill +22 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: Up to 21

Code: NCT01696721·Recruiting·Listed Oct 2012

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NEPTUNE Match Study

for Nephrotic Syndrome in Children

Sites in Chapel Hill +15 more locations

Sponsor: University of Michigan

Sex: All·Age: 1 - 80

Code: NCT04571658·Recruiting·Listed Oct 2020

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Hyaluronic Acid-based Gel Spacers in Gynecologic Malignancies

for Cervix Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT07292818·Phase 1·Recruiting·Listed Dec 2025

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Autologous CAR-T Cells Targeting B7-H3 in PDAC

for Pancreas Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06158139·Phase 1·Recruiting·Listed Dec 2023

Apply to this trial

COMPARE - Pediatric Inflammatory Bowel Disease (PIBD)

for Ulcerative Colitis, Pediatric

Sites in Chapel Hill, Durham +2 more locations

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 1 - 18

Code: NCT07198113·Recruiting·Listed Sep 2025

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Open Versus Arthroscopic Stabilization of Shoulder Instability With Subcritical Bone Loss: The OASIS Trial

for Shoulder Dislocation

Sites in Chapel Hill, Durham +8 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 17 - 50

Code: NCT04809064·Recruiting·Listed Mar 2021

Apply to this trial

Promoting Resilience in Women With Breast Cancer (PRISM -MBC)

for Breast Cancer

Sites in Chapel Hill +1 more location

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06855654·Recruiting·Listed Mar 2025

Apply to this trial

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

for Gonorrhea

Sites in Chapel Hill +12 more locations

Sponsor: Westat

Sex: Female·Age: 13 - 29

Code: NCT06738407·Phase 4·Recruiting·Listed Dec 2024

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VisR Ultrasound for Noninvasively Interrogating Stromal Collagen Organization in Women as a Breast Cancer Biomarker: Evaluation of Anisotropy in Cancer Patients

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 20 - 90

Code: NCT06878547·Recruiting·Listed Mar 2025

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Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

for Hypertensive Disorders of Pregnancy

Sites in Chapel Hill +15 more locations

Sponsor: Ohio State University

Sex: Female·Age: 14 - 35

Code: NCT06468202·Phase 4·Recruiting·Listed Jun 2024

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A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma

for Plasmablastic Lymphoma

Drug: Daratumumab

Sites in Chapel Hill +7 more locations

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT04139304·EARLY_Phase 1·Recruiting·Listed Oct 2019

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Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia

for Head and Neck Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07278557·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema

for Pleural Infection Bacterial

Sites in Chapel Hill +5 more locations

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07095361·Phase 4·Recruiting·Listed Jul 2025

Apply to this trial

Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation After Lumpectomy

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 65+

Code: NCT05472792·Phase 2·Recruiting·Listed Jul 2022

Apply to this trial

Transmission and Acquisition of Nontuberculous Mycobacteria Outbreak Investigation (TrANsMIt)

for Nontuberculous Mycobacterial Pulmonary Infection

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 1 Month - 99

Code: NCT06155747·Recruiting·Listed Dec 2023

Apply to this trial

Lupus Landmark Study: A Prospective Registry and Biorepository

for Systemic Lupus Erythematosus (SLE)

Sites in Chapel Hill +18 more locations

Sponsor: Lupus Research Alliance

Sex: All·Age: 18 - 110

Code: NCT05934149·Recruiting·Listed Jul 2023

Apply to this trial

Recovering Sleep After Trauma

for Post-traumatic Stress Disorder

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 65

Code: NCT07196332·Recruiting·Listed Sep 2025

Apply to this trial