Paid Clinical Trials in Chapel Hill, NC

As of September 2026, 702 paid clinical trials are recruiting in Chapel Hill, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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613 clinical trials

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Incremental Hemodialysis: The TwoPlus Trial

for End-Stage Kidney Disease

Sites in Chapel Hill, Winston-Salem +8 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05828823·Recruiting·Listed Apr 2023

Apply to this trial

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Chapel Hill, Durham +111 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

Apply to this trial

Dissemination of BREASTChoice AIM1-B

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07396766·Recruiting·Listed Feb 2026

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Tirzepatide in Obesity-Driven Endometrial Cancer

for Endometrial Cancer

Drug: Tirzepatide

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT07065552·EARLY_Phase 1·Recruiting·Listed Jul 2025

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QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer

for HER2-positive Metastatic Breast Cancer

Sites in Chapel Hill +36 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06551116·Recruiting·Listed Aug 2024

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Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

for Cystic Fibrosis

Sites in Chapel Hill +30 more locations

Sponsor: University of Washington, the Collaborative Health Studies Coordinating Center

Sex: All·Age: 3 - 18

Code: NCT06654752·Recruiting·Listed Oct 2024

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Impacts of Sugar Warnings on Weight Bias

for Nutrition

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07346001·Recruiting·Listed Jan 2026

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Efficacy of Tezepelumab in Peanut Oral Immunotherapy

for Peanut Allergy

Sites in Chapel Hill +9 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12 - 55

Code: NCT07015996·Phase 2·Recruiting·Listed Jun 2025

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Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07025785·Recruiting·Listed Jun 2025

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FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)

for Obesity and Overweight

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 75

Code: NCT06724406·Recruiting·Listed Dec 2024

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Effects of "Alliance180 Program" on Well-Being

for Trauma and Stressor Related Disorders

Sites in Chapel Hill +1 more location

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99

Code: NCT06451523·Recruiting·Listed Jun 2024

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Study of Trilaciclib and Lurbinectidin

for Lung Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05578326·Phase 2·Recruiting·Listed Oct 2022

Apply to this trial

Digital Art Therapy for Young Cancer Survivors

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 25

Code: NCT06789666·Recruiting·Listed Jan 2025

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Belimumab With Rituximab for Primary Membranous Nephropathy

for Membranous Nephropathy

Drug: Rituximab

Sites in Chapel Hill +19 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT03949855·Phase 2·Recruiting·Listed May 2019

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Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC

for Head and Neck Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06096038·Phase 1·Recruiting·Listed Oct 2023

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Promoting CT Engagement for Pancreatic Cancer With App

for Pancreas Cancer

Sites in Chapel Hill +1 more location

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06252545·Recruiting·Listed Feb 2024

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Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

for Barrett Esophagus

Sites in Chapel Hill +4 more locations

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06687603·Recruiting·Listed Nov 2024

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Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

for Recurrent Chronic Lymphocytic Leukemia

Drug: Mirdametinib

Sites in Chapel Hill +7 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07061951·Phase 2·Recruiting·Listed Jul 2025

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Comparing a Workplace Resilience and a Physical Activity Intervention on Early Childhood Educators Well-being

for Resilience

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06919952·Recruiting·Listed Apr 2025

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XL092 and Cemiplimab in BRAF WT Thyroid Cancer

for Anaplastic Thyroid Cancer

Drug: Cemiplimab

Sites in Chapel Hill +1 more location

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06902376·Phase 1·Recruiting·Listed Mar 2025

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Personalized Environment and Genes Study

for Diabetes

Sites in Chapel Hill & Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT00341237·Recruiting·Listed Jun 2006

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Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

for Barrett Esophagus

Sites in Chapel Hill +5 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06732388·Phase 2·Recruiting·Listed Dec 2024

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3-D Tractography FUS Ablation for Essential Tremor

for Essential Tremor

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 22+

Code: NCT06331052·Recruiting·Listed Mar 2024

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Dental-Child Interaction Training

for Behavior and Behavior Mechanisms

Sites in Chapel Hill +3 more locations

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT06138405·Recruiting·Listed Nov 2023

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Brain Slice Explants to Predict Drug Response in Brain Tumors

for Central Nervous System Tumor

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: All ages

Code: NCT05978557·Recruiting·Listed Aug 2023

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GRID Therapy for Extremity Soft Tissue Sarcoma

for Sarcoma

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06073067·Recruiting·Listed Oct 2023

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Teachers Leading the Front Lines - North Carolina (Tealeaf-NC)

for Child Behavior

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 5 - 99

Code: NCT06587230·Recruiting·Listed Sep 2024

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Faricimab + PRP vs. Vitrectomy + Endolaser for Treatment of PDR

for Proliferative Diabetic Retinopathy (PDR)

Sites in Chapel Hill +33 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT06790784·Phase 3·Recruiting·Listed Jan 2025

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Stress Trajectories and Anhedonia in Adolescence Research Study

for Anhedonia

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 13 - 15·Accepts healthy volunteers

Code: NCT07040449·Recruiting·Listed Jun 2025

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Primary Subtalar Arthrodesis for Calcaneal Fractures

for Calcaneus Fracture

Sites in Chapel Hill, Winston-Salem +15 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06249126·Recruiting·Listed Feb 2024

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The SEQUENCE Trial

for Pulmonary Nodules

Sites in Chapel Hill +4 more locations

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06676956·Recruiting·Listed Nov 2024

Apply to this trial

Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors

for Obesity

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 39

Code: NCT06848491·Recruiting·Listed Feb 2025

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The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study

for Toxicity

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT04700527·Phase 1, Phase 2·Recruiting·Listed Jan 2021

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ETHAN - ET for Male BC

for Male Breast Cancer

Sites in Chapel Hill +8 more locations

Sponsor: Jose Pablo Leone

Sex: Male·Age: 18+

Code: NCT05501704·Phase 2·Recruiting·Listed Aug 2022

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ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

for Hematologic Disorder

Sites in Chapel Hill, Winston-Salem +74 more locations

Sponsor: American Thrombosis and Hemostasis Network

Sex: All·Age: All ages

Code: NCT04398628·Recruiting·Listed May 2020

Apply to this trial

Expanding the Support of Family Caregivers of Diverse Patients With Cancer and Diabetes

for Cancer

Sites in Chapel Hill +2 more locations

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT07061652·Recruiting·Listed Jul 2025

Apply to this trial

Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer

for Breast Carcinoma

Sites in Chapel Hill +3 more locations

Sponsor: Mayo Clinic

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05557877·Phase 2·Recruiting·Listed Sep 2022

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Trial of Ovarian Vein and Pelvic Vein Embolization in Women With Chronic Pelvic Pain and Pelvic Varices

for Chronic Pelvic Pain Syndrome

Sites in Chapel Hill +2 more locations

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06168058·Recruiting·Listed Dec 2023

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Nutrition Awareness Among Women With Non-Metastatic Breast Cancer

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT07389967·Recruiting·Listed Feb 2026

Apply to this trial

Distal Radius Interventions for Fracture Treatment

for Fracture Distal Radius

Sites in Chapel Hill +23 more locations

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 4 - 10

Code: NCT05131685·Recruiting·Listed Nov 2021

Apply to this trial