Behavioral health Clinical Trials in Charleston, SC

As of July 2026, 61 paid clinical trials are recruiting for Behavioral health in Charleston, South Carolina. Behavioral health trials span mental-health pharmacotherapy and addiction treatment — testing new agents and therapies for depression, anxiety, opioid use disorder, alcohol use, and tobacco cessation. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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62 clinical trials for Behavioral health

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Treatment of Depression Post-SCI

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70

Code: NCT04263285·Recruiting·Listed Feb 2020

Apply to this trial

Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

for Generalized Anxiety Disorder

Sites in Charleston +2 more locations

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 65

Code: NCT04557891·Recruiting·Listed Sep 2020

Apply to this trial

Brief Family Involved Treatment Telehealth

for Alcohol Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT05674409·Recruiting·Listed Jan 2023

Apply to this trial

A Trial of Varenicline for E-cigarette Cessation

for E-cigarette Use

Sites in Charleston +1 more location

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07040566·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

Dosing rTMS for Depression Post-SCI

for Spinal Cord Injuries

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 60

Code: NCT05553353·Recruiting·Listed Sep 2022

Apply to this trial

Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder

for PTSD

1 location in Charleston

Sponsor: Wayne State University

Sex: All·Age: 18+

Code: NCT06740487·Recruiting·Listed Dec 2024

Apply to this trial

taVNS or TMS or Both for Depression

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 75

Code: NCT05725239·Recruiting·Listed Feb 2023

Apply to this trial

Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches

for Cigarette Smoking

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06678789·Recruiting·Listed Nov 2024

Apply to this trial

Integrated Treatment for Opioid Use Disorder and PTSD

for Opioid Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70

Code: NCT06641115·Recruiting·Listed Oct 2024

Apply to this trial

SCORE Emerging Adult Cannabis Use & Stress

for Cannabis Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 25

Code: NCT05885542·Phase 1, Phase 2·Recruiting·Listed Jun 2023

Apply to this trial

Modulating Escape Using Focused Ultrasound

for Anxiety Disorders

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT06273904·Recruiting·Listed Feb 2024

Apply to this trial

CRP and S&A for Inpatient Veterans

for Alcoholism

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05054738·Recruiting·Listed Sep 2021

Apply to this trial

A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD

for Post Traumatic Stress Disorder

Sites in Charleston +3 more locations

Sponsor: United States Department of Defense

Sex: All·Age: 18+

Code: NCT06990191·Recruiting·Listed May 2025

Apply to this trial

Evaluation of Trauma Center-Based Intervention for Adolescent Traumatic Injury Survivors

for Traumatic Injury

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 12 - 17·Accepts healthy volunteers

Code: NCT05086757·Recruiting·Listed Oct 2021

Apply to this trial

COPEWeb Training for Providers

for PTSD

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05812131·Recruiting·Listed Apr 2023

Apply to this trial

A Pilot Study of a Remote ADHD Monitoring Program

for Attention-deficit/Hyperactivity Disorder

Sites in Charleston +1 more location

Sponsor: IDeA States Pediatric Clinical Trials Network

Sex: All·Age: 5 - 11·Accepts healthy volunteers

Code: NCT06743425·Recruiting·Listed Dec 2024

Apply to this trial

Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

for Post Traumatic Stress Disorder

Sites in Charleston +3 more locations

Sponsor: United States Department of Defense

Sex: All·Age: 18+

Code: NCT06957067·Recruiting·Listed May 2025

Apply to this trial

Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care

for Depression

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 21+

Code: NCT04877197·Phase 3·Recruiting·Listed May 2021

Apply to this trial

Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders

for Bipolar Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT05064319·Phase 2·Recruiting·Listed Oct 2021

Apply to this trial

Smoking Cessation Behavioral Treatment Study

for Tobacco Use Disorder

Sites in Charleston +1 more location

Sponsor: University of Missouri-Columbia

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03948893·Recruiting·Listed May 2019

Apply to this trial

fMRI Accelerated TMS Depression

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT06562153·Recruiting·Listed Aug 2024

Apply to this trial

Conditions in Behavioral health (Charleston, SC)

Depression· 18 Tobacco / nicotine use· 17 PTSD (post-traumatic stress disorder)· 13 Opioid use disorder· 7 Cannabis use / cannabis use disorder· 7 Substance use disorder· 6 Anxiety· 5 Alcohol use disorder· 5 ADHD· 2 Bipolar disorder· 1